Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138005943> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2138005943 abstract "Transplantation of solid organs is the treatment of choice for most patients with end-stage organ diseases. In the absence of pharmacological immunosuppression, recognition of foreign (allogeneic) histocompatibility proteins expressed on donor cells by the recipient's immune system results in rejection of the transplanted tissue(s). One-year renal transplant survival is now routinely over 90% in most centres, largely the result of improvements in immunosuppressive drugs. In this article, we review commonly used immunosuppressive medications and discuss their pharmacological modes of action. Given that long-term graft outcomes remain poor despite improvements in early transplant survival, we discuss, in addition, novel experimental strategies for the induction of tolerance to transplanted tissues that have translational relevance to human organ recipients.Key Concepts: The major limitation of solid organ transplantation is long-term immunosuppression which either results in excessive mortality and morbidity or is insufficient to prevent chronic rejection of transplanted tissues.An understanding of transplant rejection and pharmacological targets of immunosuppression is key to devising novel strategies of preventing rejection by inducing transplant tolerance.Keywords:transplantation;rejection;tissue typing;immunosuppression" @default.
- W2138005943 created "2016-06-24" @default.
- W2138005943 creator A5010690912 @default.
- W2138005943 creator A5011934276 @default.
- W2138005943 creator A5019533207 @default.
- W2138005943 date "2010-09-15" @default.
- W2138005943 modified "2023-09-26" @default.
- W2138005943 title "Graft Rejection: Immunological Suppression" @default.
- W2138005943 cites W1497954397 @default.
- W2138005943 cites W1528584436 @default.
- W2138005943 cites W1661544713 @default.
- W2138005943 cites W1996396635 @default.
- W2138005943 cites W2019177796 @default.
- W2138005943 cites W2020853616 @default.
- W2138005943 cites W2034337172 @default.
- W2138005943 cites W2036276239 @default.
- W2138005943 cites W2044306073 @default.
- W2138005943 cites W2054083392 @default.
- W2138005943 cites W2074591330 @default.
- W2138005943 cites W2085027215 @default.
- W2138005943 cites W2085108146 @default.
- W2138005943 cites W2089652099 @default.
- W2138005943 cites W2102221374 @default.
- W2138005943 cites W2144130278 @default.
- W2138005943 cites W2148226248 @default.
- W2138005943 cites W2161116664 @default.
- W2138005943 cites W2162495518 @default.
- W2138005943 cites W2171274461 @default.
- W2138005943 cites W4233298376 @default.
- W2138005943 doi "https://doi.org/10.1002/9780470015902.a0001231.pub2" @default.
- W2138005943 hasPublicationYear "2010" @default.
- W2138005943 type Work @default.
- W2138005943 sameAs 2138005943 @default.
- W2138005943 citedByCount "1" @default.
- W2138005943 countsByYear W21380059432015 @default.
- W2138005943 crossrefType "reference-entry" @default.
- W2138005943 hasAuthorship W2138005943A5010690912 @default.
- W2138005943 hasAuthorship W2138005943A5011934276 @default.
- W2138005943 hasAuthorship W2138005943A5019533207 @default.
- W2138005943 hasConcept C126322002 @default.
- W2138005943 hasConcept C203014093 @default.
- W2138005943 hasConcept C2911091166 @default.
- W2138005943 hasConcept C3019230761 @default.
- W2138005943 hasConcept C71924100 @default.
- W2138005943 hasConcept C86803240 @default.
- W2138005943 hasConceptScore W2138005943C126322002 @default.
- W2138005943 hasConceptScore W2138005943C203014093 @default.
- W2138005943 hasConceptScore W2138005943C2911091166 @default.
- W2138005943 hasConceptScore W2138005943C3019230761 @default.
- W2138005943 hasConceptScore W2138005943C71924100 @default.
- W2138005943 hasConceptScore W2138005943C86803240 @default.
- W2138005943 hasLocation W21380059431 @default.
- W2138005943 hasOpenAccess W2138005943 @default.
- W2138005943 hasPrimaryLocation W21380059431 @default.
- W2138005943 hasRelatedWork W1490091059 @default.
- W2138005943 hasRelatedWork W1983567575 @default.
- W2138005943 hasRelatedWork W1997135307 @default.
- W2138005943 hasRelatedWork W2022167511 @default.
- W2138005943 hasRelatedWork W2040278279 @default.
- W2138005943 hasRelatedWork W2052247067 @default.
- W2138005943 hasRelatedWork W2071532507 @default.
- W2138005943 hasRelatedWork W2085067891 @default.
- W2138005943 hasRelatedWork W4221095572 @default.
- W2138005943 hasRelatedWork W4254348658 @default.
- W2138005943 isParatext "false" @default.
- W2138005943 isRetracted "false" @default.
- W2138005943 magId "2138005943" @default.
- W2138005943 workType "reference-entry" @default.