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• W2138023086 abstract "<h3>Background</h3> Several genes identified by positional cloning have been associated with asthma and atopy, but few findings have been replicated. Age at onset of asthma has been associated with different phenotypic characteristics, and with variants at chromosome 17q21 identified through genome-wide association. This study examined the associations and age-specific effects on asthma, atopy and bronchial hyper-responsiveness (BHR) of five candidate genes previously identified by positional cloning (<i>ADAM33, PHF11, NPSR1, DPP10, SPINK5</i>). <h3>Methods</h3> 51 polymorphisms from 2474 participants from 13 countries who took part in the European Community Respiratory Health Survey (1990–2000) were studied. Asthma and age at onset of asthma were assessed by questionnaire data, BHR by methacholine challenge and atopy by specific immunoglobulin E to four common allergens. <h3>Results</h3> Significant associations with asthma, atopy and particularly for asthma with atopy were observed for a large region of 47 kb in the <i>NPSR1</i> gene, even after Bonferroni correction for multiple comparisons (p<0.001). The associations with <i>NPSR1</i> were stronger in those reporting a first attack of asthma before the age of 15, with statistically significant interactions with age of onset found for three SNPs. The evidence for <i>ADAM33</i> and BHR and for an age-specific effect of two SNPs in <i>DPP10</i> and asthma was weaker. <h3>Conclusion</h3> This study provides further evidence for an effect of <i>NPSR1</i> on asthma, atopy and atopic asthma. In addition, this analysis suggests a role for <i>NPSR1</i> in early-onset asthma driven by the strong effect of this gene on atopic asthma." @default.
• W2138023086 created "2016-06-24" @default.
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• W2138023086 date "2009-12-08" @default.
• W2138023086 modified "2023-10-15" @default.
• W2138023086 title "Positionally cloned genes and age-specific effects in asthma and atopy: an international population-based cohort study (ECRHS)" @default.
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• W2138023086 doi "https://doi.org/10.1136/thx.2009.119628" @default.
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