Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138033736> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2138033736 endingPage "443" @default.
- W2138033736 startingPage "437" @default.
- W2138033736 abstract "Background Hepatic veno-occlusive disease (VOD) is one of the most serious complications in stem cell transplantation (SCT). Although plasma protein C activity decreases in VOD after SCT, the timeframe of plasma protein C activity decreases during SCT is not known. Procedure We examined levels of plasma protein C serially during the course of SCT to determine the critical level and risk factors for VOD. Results Of 151 children who received SCT, 12 of them (7.9%) developed VOD. The mean minimum protein C activity in patients with VOD was significantly lower compared to that in patients without VOD (P < 0.0001). Receiver operating characteristic curve analysis revealed that the critical plasma protein C activity (cut-off point) for VOD was identified to be 34.5% with high sensitivity (100%) and specificity (83.3%), and the reduction of plasma protein C below the cut-off level (day +6.50 ± 2.43) was observed mostly prior to the onset of VOD (day +7.33 ± 2.64). The patients receiving melphalan in conditioning were found to be at high risk for VOD (P = 0.003). Among the melphalan containing regimens, melphalan + carboplatin + etoposide was a significant risk factor for depression of plasma protein C (P = 0.037). Conclusion Plasma protein C level was a useful parameter of VOD after SCT, and activity below 34.5% was critical for VOD. The use of melphalan in conditioning causes a high risk for VOD. Pediatr Blood Cancer 2010;54:437–443. © 2009 Wiley-Liss, Inc." @default.
- W2138033736 created "2016-06-24" @default.
- W2138033736 creator A5026840406 @default.
- W2138033736 creator A5028305352 @default.
- W2138033736 creator A5029655825 @default.
- W2138033736 creator A5064922173 @default.
- W2138033736 date "2009-11-12" @default.
- W2138033736 modified "2023-10-16" @default.
- W2138033736 title "Plasma protein C is a useful clinical marker for hepatic veno-occlusive disease (VOD) in stem cell transplantation" @default.
- W2138033736 cites W1964574276 @default.
- W2138033736 cites W1965494990 @default.
- W2138033736 cites W1969063643 @default.
- W2138033736 cites W1972172571 @default.
- W2138033736 cites W2011330820 @default.
- W2138033736 cites W2012187988 @default.
- W2138033736 cites W2020498100 @default.
- W2138033736 cites W2022481190 @default.
- W2138033736 cites W2053278212 @default.
- W2138033736 cites W2064945216 @default.
- W2138033736 cites W2066452515 @default.
- W2138033736 cites W2076488792 @default.
- W2138033736 cites W2124413048 @default.
- W2138033736 cites W2151348405 @default.
- W2138033736 cites W2155601162 @default.
- W2138033736 cites W2323586541 @default.
- W2138033736 cites W2325927831 @default.
- W2138033736 cites W2332592622 @default.
- W2138033736 cites W2402196343 @default.
- W2138033736 cites W4235287384 @default.
- W2138033736 cites W71585368 @default.
- W2138033736 cites W95208818 @default.
- W2138033736 doi "https://doi.org/10.1002/pbc.22314" @default.
- W2138033736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19911420" @default.
- W2138033736 hasPublicationYear "2009" @default.
- W2138033736 type Work @default.
- W2138033736 sameAs 2138033736 @default.
- W2138033736 citedByCount "20" @default.
- W2138033736 countsByYear W21380337362012 @default.
- W2138033736 countsByYear W21380337362013 @default.
- W2138033736 countsByYear W21380337362014 @default.
- W2138033736 countsByYear W21380337362015 @default.
- W2138033736 countsByYear W21380337362017 @default.
- W2138033736 countsByYear W21380337362018 @default.
- W2138033736 countsByYear W21380337362019 @default.
- W2138033736 countsByYear W21380337362021 @default.
- W2138033736 crossrefType "journal-article" @default.
- W2138033736 hasAuthorship W2138033736A5026840406 @default.
- W2138033736 hasAuthorship W2138033736A5028305352 @default.
- W2138033736 hasAuthorship W2138033736A5029655825 @default.
- W2138033736 hasAuthorship W2138033736A5064922173 @default.
- W2138033736 hasConcept C126322002 @default.
- W2138033736 hasConcept C143998085 @default.
- W2138033736 hasConcept C146543888 @default.
- W2138033736 hasConcept C2776694085 @default.
- W2138033736 hasConcept C2777408962 @default.
- W2138033736 hasConcept C2778119113 @default.
- W2138033736 hasConcept C2778684742 @default.
- W2138033736 hasConcept C2780895475 @default.
- W2138033736 hasConcept C2911091166 @default.
- W2138033736 hasConcept C71924100 @default.
- W2138033736 hasConcept C90924648 @default.
- W2138033736 hasConceptScore W2138033736C126322002 @default.
- W2138033736 hasConceptScore W2138033736C143998085 @default.
- W2138033736 hasConceptScore W2138033736C146543888 @default.
- W2138033736 hasConceptScore W2138033736C2776694085 @default.
- W2138033736 hasConceptScore W2138033736C2777408962 @default.
- W2138033736 hasConceptScore W2138033736C2778119113 @default.
- W2138033736 hasConceptScore W2138033736C2778684742 @default.
- W2138033736 hasConceptScore W2138033736C2780895475 @default.
- W2138033736 hasConceptScore W2138033736C2911091166 @default.
- W2138033736 hasConceptScore W2138033736C71924100 @default.
- W2138033736 hasConceptScore W2138033736C90924648 @default.
- W2138033736 hasIssue "3" @default.
- W2138033736 hasLocation W21380337361 @default.
- W2138033736 hasLocation W21380337362 @default.
- W2138033736 hasOpenAccess W2138033736 @default.
- W2138033736 hasPrimaryLocation W21380337361 @default.
- W2138033736 hasRelatedWork W1964442698 @default.
- W2138033736 hasRelatedWork W1987997012 @default.
- W2138033736 hasRelatedWork W2035589037 @default.
- W2138033736 hasRelatedWork W2036869970 @default.
- W2138033736 hasRelatedWork W2039555364 @default.
- W2138033736 hasRelatedWork W2098098669 @default.
- W2138033736 hasRelatedWork W2399914353 @default.
- W2138033736 hasRelatedWork W2432246041 @default.
- W2138033736 hasRelatedWork W2432397496 @default.
- W2138033736 hasRelatedWork W2471957740 @default.
- W2138033736 hasVolume "54" @default.
- W2138033736 isParatext "false" @default.
- W2138033736 isRetracted "false" @default.
- W2138033736 magId "2138033736" @default.
- W2138033736 workType "article" @default.