Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138045302> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2138045302 endingPage "355" @default.
- W2138045302 startingPage "349" @default.
- W2138045302 abstract "Replication of the D variant of encephalomyocarditis virus (EMC-D) and its cytopathic effects were studied in the brain slice cultures including hippocampus (hippocampal slice) obtained from postnatal 1-, 4-, 7-, 14-, 28-and 56-day-old Fischer 344 rats. At 0, 12, 24, 36 and 48 h after infection, virus titres of the slices and culture media were assayed. Viral replication was observed in cultures from 1-to 28-day-old rats, and the highest titre was recorded in the slice and culture medium from the youngest rat. The peak of virus titre decreased with age and no distinct viral replication was observed in the cultures from 56-day-old rats. Light microscopy revealed that degenerative and necrotic changes appeared in the infected hippocampal slices from 1- to 28-day-old rats, and the changes became less prominent with age. In situ hybridization and indirect immunofluorescence staining showed that positive signals of viral RNA and antigen were prominent in younger rats and decreased with age. These results suggest that an age-related decrease in the susceptibility of rat brain to EMC-D is less related to the maturation of the immune system but possibly to that of the neurone." @default.
- W2138045302 created "2016-06-24" @default.
- W2138045302 creator A5019910221 @default.
- W2138045302 creator A5034417976 @default.
- W2138045302 creator A5051636973 @default.
- W2138045302 creator A5082886918 @default.
- W2138045302 creator A5086535576 @default.
- W2138045302 date "2001-12-25" @default.
- W2138045302 modified "2023-10-02" @default.
- W2138045302 title "Age-related changes in susceptibility of rat brain slice cultures including hippocampus to encephalomyocarditis virus" @default.
- W2138045302 cites W109137279 @default.
- W2138045302 cites W1157427993 @default.
- W2138045302 cites W1494952434 @default.
- W2138045302 cites W1496968114 @default.
- W2138045302 cites W1531836164 @default.
- W2138045302 cites W1534806564 @default.
- W2138045302 cites W1959644357 @default.
- W2138045302 cites W1983806530 @default.
- W2138045302 cites W2000693050 @default.
- W2138045302 cites W2007013170 @default.
- W2138045302 cites W2016007572 @default.
- W2138045302 cites W2030818093 @default.
- W2138045302 cites W2038152355 @default.
- W2138045302 cites W2040407112 @default.
- W2138045302 cites W2040738644 @default.
- W2138045302 cites W2055897229 @default.
- W2138045302 cites W2063726095 @default.
- W2138045302 cites W2079804397 @default.
- W2138045302 cites W2087557066 @default.
- W2138045302 cites W2136117294 @default.
- W2138045302 cites W2141413614 @default.
- W2138045302 cites W2169107178 @default.
- W2138045302 cites W2411920476 @default.
- W2138045302 cites W2472900661 @default.
- W2138045302 doi "https://doi.org/10.1046/j.1365-2613.1999.00133.x" @default.
- W2138045302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2517839" @default.
- W2138045302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10632784" @default.
- W2138045302 hasPublicationYear "2001" @default.
- W2138045302 type Work @default.
- W2138045302 sameAs 2138045302 @default.
- W2138045302 citedByCount "5" @default.
- W2138045302 countsByYear W21380453022017 @default.
- W2138045302 crossrefType "journal-article" @default.
- W2138045302 hasAuthorship W2138045302A5019910221 @default.
- W2138045302 hasAuthorship W2138045302A5034417976 @default.
- W2138045302 hasAuthorship W2138045302A5051636973 @default.
- W2138045302 hasAuthorship W2138045302A5082886918 @default.
- W2138045302 hasAuthorship W2138045302A5086535576 @default.
- W2138045302 hasBestOaLocation W21380453022 @default.
- W2138045302 hasConcept C134018914 @default.
- W2138045302 hasConcept C140704245 @default.
- W2138045302 hasConcept C148762608 @default.
- W2138045302 hasConcept C159047783 @default.
- W2138045302 hasConcept C159654299 @default.
- W2138045302 hasConcept C203014093 @default.
- W2138045302 hasConcept C2522874641 @default.
- W2138045302 hasConcept C2775996393 @default.
- W2138045302 hasConcept C2778236600 @default.
- W2138045302 hasConcept C2781161787 @default.
- W2138045302 hasConcept C29694410 @default.
- W2138045302 hasConcept C32611913 @default.
- W2138045302 hasConcept C529278444 @default.
- W2138045302 hasConcept C86803240 @default.
- W2138045302 hasConceptScore W2138045302C134018914 @default.
- W2138045302 hasConceptScore W2138045302C140704245 @default.
- W2138045302 hasConceptScore W2138045302C148762608 @default.
- W2138045302 hasConceptScore W2138045302C159047783 @default.
- W2138045302 hasConceptScore W2138045302C159654299 @default.
- W2138045302 hasConceptScore W2138045302C203014093 @default.
- W2138045302 hasConceptScore W2138045302C2522874641 @default.
- W2138045302 hasConceptScore W2138045302C2775996393 @default.
- W2138045302 hasConceptScore W2138045302C2778236600 @default.
- W2138045302 hasConceptScore W2138045302C2781161787 @default.
- W2138045302 hasConceptScore W2138045302C29694410 @default.
- W2138045302 hasConceptScore W2138045302C32611913 @default.
- W2138045302 hasConceptScore W2138045302C529278444 @default.
- W2138045302 hasConceptScore W2138045302C86803240 @default.
- W2138045302 hasIssue "6" @default.
- W2138045302 hasLocation W21380453021 @default.
- W2138045302 hasLocation W21380453022 @default.
- W2138045302 hasLocation W21380453023 @default.
- W2138045302 hasOpenAccess W2138045302 @default.
- W2138045302 hasPrimaryLocation W21380453021 @default.
- W2138045302 hasRelatedWork W1520753096 @default.
- W2138045302 hasRelatedWork W2012539582 @default.
- W2138045302 hasRelatedWork W2015925567 @default.
- W2138045302 hasRelatedWork W2078027579 @default.
- W2138045302 hasRelatedWork W2090767490 @default.
- W2138045302 hasRelatedWork W2350366197 @default.
- W2138045302 hasRelatedWork W2350727189 @default.
- W2138045302 hasRelatedWork W2359331237 @default.
- W2138045302 hasRelatedWork W2512173364 @default.
- W2138045302 hasRelatedWork W345283420 @default.
- W2138045302 hasVolume "80" @default.
- W2138045302 isParatext "false" @default.
- W2138045302 isRetracted "false" @default.
- W2138045302 magId "2138045302" @default.
- W2138045302 workType "article" @default.