FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138049586> ?p ?o ?g. }

• W2138049586 endingPage "362" @default.
• W2138049586 startingPage "354" @default.
• W2138049586 abstract "Evaluation of HER2 gene amplification in breast cancers is a compelling, routine procedure. The aim of this work was to evaluate which breast carcinomas would really benefit from HER-2/neu gene analysis.We studied 130 invasive breast carcinomas by immunohistochemistry (IHC) using CB11 and TAB250 MAbs directed against different domains of the c-erbB2 molecule. From this series, we selected 106 cases (32 G1, 36 G2, and 38 G3) in which HER-2/neu gene analysis, using chromogenic in-situ hybridization (CISH), was successful. IHC results were scored using the FDA approved system with three score values: 0/1+ (negative), 2+, 3+ (positive). In addition, we developed a double scoring system with six score values (0/1+ 2+ negative, 3+, 4+, 5+, 6+ positive) obtained by summating the individual scoring values obtained with each MAb. All double scoring negative cases were non-amplified (100% sensitivity), whereas all cases scored 6+ were amplified. Double scoring values and CISH results were then correlated with grade and histological type. G1 ductal carcinomas and carcinomas of lobular and of special histological type did not show HER-2/neu amplification even in the presence of protein over-expression.The combined results of IHC analysis (double scoring values) obtained using MAbs directed against different c-erbB2 domains correctly indicates the HER-2/neu gene status in 57.5% of cases. In addition, simple morphological features such as low grade and special histological type are good predictors of the non-amplification of the HER-2/neu gene in breast carcinoma." @default.
• W2138049586 created "2016-06-24" @default.
• W2138049586 creator A5007353499 @default.
• W2138049586 creator A5010186225 @default.
• W2138049586 creator A5039435568 @default.
• W2138049586 creator A5045011793 @default.
• W2138049586 creator A5054916452 @default.
• W2138049586 creator A5056332852 @default.
• W2138049586 creator A5056944296 @default.
• W2138049586 creator A5063939706 @default.
• W2138049586 creator A5089164502 @default.
• W2138049586 date "2003-09-26" @default.
• W2138049586 modified "2023-10-15" @default.
• W2138049586 title "Which breast carcinomas need HER-2/<i>neu</i> gene study after immunohistochemical analysis? Results of combined use of antibodies against different c-erbB2 protein domains" @default.
• W2138049586 cites W1574208759 @default.
• W2138049586 cites W1904016327 @default.
• W2138049586 cites W1973415051 @default.
• W2138049586 cites W1980892822 @default.
• W2138049586 cites W2006174096 @default.
• W2138049586 cites W2007233147 @default.
• W2138049586 cites W2010871781 @default.
• W2138049586 cites W2014909020 @default.
• W2138049586 cites W2021532283 @default.
• W2138049586 cites W2032769373 @default.
• W2138049586 cites W2052392813 @default.
• W2138049586 cites W2053488663 @default.
• W2138049586 cites W2071130163 @default.
• W2138049586 cites W2072648072 @default.
• W2138049586 cites W2093986016 @default.
• W2138049586 cites W2104528117 @default.
• W2138049586 cites W2112068063 @default.
• W2138049586 cites W2114389974 @default.
• W2138049586 cites W2125730396 @default.
• W2138049586 cites W2133407636 @default.
• W2138049586 cites W2141393790 @default.
• W2138049586 cites W2148876744 @default.
• W2138049586 cites W4239989216 @default.
• W2138049586 cites W4250260746 @default.
• W2138049586 doi "https://doi.org/10.1046/j.1365-2559.2003.01708.x" @default.
• W2138049586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14511254" @default.
• W2138049586 hasPublicationYear "2003" @default.
• W2138049586 type Work @default.
• W2138049586 sameAs 2138049586 @default.
• W2138049586 citedByCount "24" @default.
• W2138049586 countsByYear W21380495862012 @default.
• W2138049586 countsByYear W21380495862013 @default.
• W2138049586 countsByYear W21380495862015 @default.
• W2138049586 countsByYear W21380495862019 @default.
• W2138049586 crossrefType "journal-article" @default.
• W2138049586 hasAuthorship W2138049586A5007353499 @default.
• W2138049586 hasAuthorship W2138049586A5010186225 @default.
• W2138049586 hasAuthorship W2138049586A5039435568 @default.
• W2138049586 hasAuthorship W2138049586A5045011793 @default.
• W2138049586 hasAuthorship W2138049586A5054916452 @default.
• W2138049586 hasAuthorship W2138049586A5056332852 @default.
• W2138049586 hasAuthorship W2138049586A5056944296 @default.
• W2138049586 hasAuthorship W2138049586A5063939706 @default.
• W2138049586 hasAuthorship W2138049586A5089164502 @default.
• W2138049586 hasConcept C104317684 @default.
• W2138049586 hasConcept C121313828 @default.
• W2138049586 hasConcept C121608353 @default.
• W2138049586 hasConcept C126322002 @default.
• W2138049586 hasConcept C142724271 @default.
• W2138049586 hasConcept C143998085 @default.
• W2138049586 hasConcept C150194340 @default.
• W2138049586 hasConcept C204232928 @default.
• W2138049586 hasConcept C2776372563 @default.
• W2138049586 hasConcept C2776643354 @default.
• W2138049586 hasConcept C2777546739 @default.
• W2138049586 hasConcept C3018521938 @default.
• W2138049586 hasConcept C3020375857 @default.
• W2138049586 hasConcept C530470458 @default.
• W2138049586 hasConcept C55493867 @default.
• W2138049586 hasConcept C71924100 @default.
• W2138049586 hasConcept C7602840 @default.
• W2138049586 hasConcept C81089528 @default.
• W2138049586 hasConcept C81439078 @default.
• W2138049586 hasConcept C86803240 @default.
• W2138049586 hasConceptScore W2138049586C104317684 @default.
• W2138049586 hasConceptScore W2138049586C121313828 @default.
• W2138049586 hasConceptScore W2138049586C121608353 @default.
• W2138049586 hasConceptScore W2138049586C126322002 @default.
• W2138049586 hasConceptScore W2138049586C142724271 @default.
• W2138049586 hasConceptScore W2138049586C143998085 @default.
• W2138049586 hasConceptScore W2138049586C150194340 @default.
• W2138049586 hasConceptScore W2138049586C204232928 @default.
• W2138049586 hasConceptScore W2138049586C2776372563 @default.
• W2138049586 hasConceptScore W2138049586C2776643354 @default.
• W2138049586 hasConceptScore W2138049586C2777546739 @default.
• W2138049586 hasConceptScore W2138049586C3018521938 @default.
• W2138049586 hasConceptScore W2138049586C3020375857 @default.
• W2138049586 hasConceptScore W2138049586C530470458 @default.
• W2138049586 hasConceptScore W2138049586C55493867 @default.
• W2138049586 hasConceptScore W2138049586C71924100 @default.
• W2138049586 hasConceptScore W2138049586C7602840 @default.
• W2138049586 hasConceptScore W2138049586C81089528 @default.
• W2138049586 hasConceptScore W2138049586C81439078 @default.
• W2138049586 hasConceptScore W2138049586C86803240 @default.

• next