FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138055832> ?p ?o ?g. }

• W2138055832 endingPage "1913" @default.
• W2138055832 startingPage "1909" @default.
• W2138055832 abstract "In previous studies, IL-4 has been reported to interfere with IL-2-driven generation of lymphokine-activated killer (LAK) activity. In this investigation, we have demonstrated that IL-4 inhibited the IL-2-induced differentiation of large granular lymphocytes (LGL) into LAK effectors by a mechanism involving, at least in part, an increase in LGL intracellular cAMP levels. In contrast, with its capacity to induce cAMP accumulation in resting LGL, IL-4 had a very negligible effect on LAK activity induction, and cAMP levels increase in LGL that had been preincubated with IL-2. Furthermore, the inhibitory effect of IL-4 on LAK activity generation also correlated with a marked decrease in N-CBZ-L-lysine thiobenzylester esterase activity, with an inhibition of tumor necrosis factor (TNF) mRNA expression and TNF production by IL-2-stimulated LGL. These results strongly suggest that complex signaling processes could be ascribed to the dual activities of cytokines and their interplay in LAK promotion." @default.
• W2138055832 created "2016-06-24" @default.
• W2138055832 creator A5040644501 @default.
• W2138055832 creator A5042202815 @default.
• W2138055832 creator A5042650571 @default.
• W2138055832 creator A5045530749 @default.
• W2138055832 creator A5073092303 @default.
• W2138055832 date "1990-06-01" @default.
• W2138055832 modified "2023-09-27" @default.
• W2138055832 title "Involvement of cyclic adenosine monophosphate in the interleukin 4 inhibitory effect on interleukin 2-induced lymphokine-activated killer generation." @default.
• W2138055832 cites W1481598923 @default.
• W2138055832 cites W1485870594 @default.
• W2138055832 cites W1510707687 @default.
• W2138055832 cites W1512580729 @default.
• W2138055832 cites W1545223299 @default.
• W2138055832 cites W1551770882 @default.
• W2138055832 cites W1572320758 @default.
• W2138055832 cites W1944420820 @default.
• W2138055832 cites W1965107244 @default.
• W2138055832 cites W1967494967 @default.
• W2138055832 cites W1973924785 @default.
• W2138055832 cites W1986202661 @default.
• W2138055832 cites W2020976163 @default.
• W2138055832 cites W2046432457 @default.
• W2138055832 cites W2063068982 @default.
• W2138055832 cites W2077077811 @default.
• W2138055832 cites W2092477408 @default.
• W2138055832 cites W2093107928 @default.
• W2138055832 cites W2099826413 @default.
• W2138055832 cites W2112941906 @default.
• W2138055832 cites W2116996002 @default.
• W2138055832 cites W2119835942 @default.
• W2138055832 cites W2134828784 @default.
• W2138055832 cites W2138709393 @default.
• W2138055832 cites W2141298931 @default.
• W2138055832 cites W2146719176 @default.
• W2138055832 doi "https://doi.org/10.1172/jci114653" @default.
• W2138055832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296658" @default.
• W2138055832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2161432" @default.
• W2138055832 hasPublicationYear "1990" @default.
• W2138055832 type Work @default.
• W2138055832 sameAs 2138055832 @default.
• W2138055832 citedByCount "18" @default.
• W2138055832 countsByYear W21380558322013 @default.
• W2138055832 crossrefType "journal-article" @default.
• W2138055832 hasAuthorship W2138055832A5040644501 @default.
• W2138055832 hasAuthorship W2138055832A5042202815 @default.
• W2138055832 hasAuthorship W2138055832A5042650571 @default.
• W2138055832 hasAuthorship W2138055832A5045530749 @default.
• W2138055832 hasAuthorship W2138055832A5073092303 @default.
• W2138055832 hasBestOaLocation W21380558321 @default.
• W2138055832 hasConcept C126322002 @default.
• W2138055832 hasConcept C129374314 @default.
• W2138055832 hasConcept C134018914 @default.
• W2138055832 hasConcept C170493617 @default.
• W2138055832 hasConcept C17991360 @default.
• W2138055832 hasConcept C185592680 @default.
• W2138055832 hasConcept C191732599 @default.
• W2138055832 hasConcept C203014093 @default.
• W2138055832 hasConcept C2776090121 @default.
• W2138055832 hasConcept C2776668983 @default.
• W2138055832 hasConcept C2776991684 @default.
• W2138055832 hasConcept C2777371288 @default.
• W2138055832 hasConcept C2778690821 @default.
• W2138055832 hasConcept C28651165 @default.
• W2138055832 hasConcept C49382859 @default.
• W2138055832 hasConcept C55493867 @default.
• W2138055832 hasConcept C71924100 @default.
• W2138055832 hasConcept C86803240 @default.
• W2138055832 hasConcept C8891405 @default.
• W2138055832 hasConceptScore W2138055832C126322002 @default.
• W2138055832 hasConceptScore W2138055832C129374314 @default.
• W2138055832 hasConceptScore W2138055832C134018914 @default.
• W2138055832 hasConceptScore W2138055832C170493617 @default.
• W2138055832 hasConceptScore W2138055832C17991360 @default.
• W2138055832 hasConceptScore W2138055832C185592680 @default.
• W2138055832 hasConceptScore W2138055832C191732599 @default.
• W2138055832 hasConceptScore W2138055832C203014093 @default.
• W2138055832 hasConceptScore W2138055832C2776090121 @default.
• W2138055832 hasConceptScore W2138055832C2776668983 @default.
• W2138055832 hasConceptScore W2138055832C2776991684 @default.
• W2138055832 hasConceptScore W2138055832C2777371288 @default.
• W2138055832 hasConceptScore W2138055832C2778690821 @default.
• W2138055832 hasConceptScore W2138055832C28651165 @default.
• W2138055832 hasConceptScore W2138055832C49382859 @default.
• W2138055832 hasConceptScore W2138055832C55493867 @default.
• W2138055832 hasConceptScore W2138055832C71924100 @default.
• W2138055832 hasConceptScore W2138055832C86803240 @default.
• W2138055832 hasConceptScore W2138055832C8891405 @default.
• W2138055832 hasIssue "6" @default.
• W2138055832 hasLocation W21380558321 @default.
• W2138055832 hasLocation W21380558322 @default.
• W2138055832 hasLocation W21380558323 @default.
• W2138055832 hasLocation W21380558324 @default.
• W2138055832 hasOpenAccess W2138055832 @default.
• W2138055832 hasPrimaryLocation W21380558321 @default.
• W2138055832 hasRelatedWork W2045445350 @default.
• W2138055832 hasRelatedWork W2065224155 @default.

• next