FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138065633> ?p ?o ?g. }

• W2138065633 endingPage "46" @default.
• W2138065633 startingPage "31" @default.
• W2138065633 abstract "Objectives Forsythiae Fructus treatment has been used for inflammatory and allergic diseases in Korean Medicine. Nevertheless, the mechanism of action and the cellular targets are not understood well. The pathogenesis of allergic diseases are associated with Th2 cytokines such as IL-13, MIP-<TEX>$1{alpha}$</TEX>, IL-13, IL-5, GM-CSF, IL-4, TNF-<TEX>${alpha}$</TEX> and IL-6, which are secreted by the mast cells. This study was conducted to investigate the effects of Forsythiae Fructus extracts (FF) on Th2 cytokines expression and signal transduction in MC/9 mast cells. Methods In the study, MC/9 mast cells were stimulated with DNP-IgE for 24 hours and then treated separately with CsA <TEX>$10{mu}g/m{ell}$</TEX> and varying doses of FF for one hour. MC/9 mast cells stimulated with DNP-IgE was the control group, a treatment with CsA was the positive control group and a treatment with varying doses FF was the experimental groups. The mRNA levels of IL-13, IL-5, GM-CSF, IL-4, TNF-<TEX>${alpha}$</TEX>, IL-6 were analyzed with Real-time PCR. The levels of IL-13, MIP-<TEX>$1{alpha}$</TEX> were measured using enzyme-linked immunosorbent assays(ELISA). NFAT, AP-1 and NF-<TEX>${kappa}B$</TEX> p65 were examined by Western blot analysis. Results 1. FF were observed to suppress the mRNA expression of IL-13, IL-5, GM-CSF, IL-4, TNF-<TEX>${alpha}$</TEX>, IL-6 in comparison to DNP-IgE control group. 2. FF also has inhibited the IL-13, MIP-<TEX>$1{alpha}$</TEX> production significantly in comparison to DNP-IgE control group. 3. Western blot analysis of transduction factors involving Th2 cytokines expression has revealed a prominent decrease of the mast cell specific transduction factors including NFAT-1, NFAT-2, c-Jun, and NF-<TEX>${kappa}B$</TEX> p65 but c-Fos. Conclusions In conclusion, the anti-allergenic activities of FF may be strongly related to the regulation of transcription factors NFAT-1, NFAT-2, c-Jun, and NF-<TEX>${kappa}B$</TEX> p65 causing inhibition of Th2 cytokines in mast cells." @default.
• W2138065633 created "2016-06-24" @default.
• W2138065633 creator A5000741482 @default.
• W2138065633 creator A5052838486 @default.
• W2138065633 creator A5089253487 @default.
• W2138065633 date "2014-08-31" @default.
• W2138065633 modified "2023-09-26" @default.
• W2138065633 title "The Suppressive Effect of Th2 Cytokines Expression and the Signal Transduction Mechanism in MC/9 Mast Cells by Forsythiae Fructus Extracts" @default.
• W2138065633 cites W1514144285 @default.
• W2138065633 cites W1973529984 @default.
• W2138065633 cites W1984974974 @default.
• W2138065633 cites W1987086586 @default.
• W2138065633 cites W1990636293 @default.
• W2138065633 cites W1992226558 @default.
• W2138065633 cites W2007318225 @default.
• W2138065633 cites W2011657904 @default.
• W2138065633 cites W2016345560 @default.
• W2138065633 cites W2058158294 @default.
• W2138065633 cites W2064895226 @default.
• W2138065633 cites W2066464079 @default.
• W2138065633 cites W2074459306 @default.
• W2138065633 cites W2075868099 @default.
• W2138065633 cites W2088679944 @default.
• W2138065633 cites W2100664574 @default.
• W2138065633 cites W2116003183 @default.
• W2138065633 cites W2129569282 @default.
• W2138065633 cites W2137847782 @default.
• W2138065633 cites W2172466148 @default.
• W2138065633 cites W2263976865 @default.
• W2138065633 cites W2296776321 @default.
• W2138065633 cites W2299343461 @default.
• W2138065633 cites W2340659486 @default.
• W2138065633 cites W2407977694 @default.
• W2138065633 cites W258610349 @default.
• W2138065633 cites W890781994 @default.
• W2138065633 cites W894613995 @default.
• W2138065633 cites W920775369 @default.
• W2138065633 cites W1983502784 @default.
• W2138065633 cites W2256323259 @default.
• W2138065633 cites W2942756152 @default.
• W2138065633 doi "https://doi.org/10.7778/jpkm.2014.28.3.031" @default.
• W2138065633 hasPublicationYear "2014" @default.
• W2138065633 type Work @default.
• W2138065633 sameAs 2138065633 @default.
• W2138065633 citedByCount "0" @default.
• W2138065633 crossrefType "journal-article" @default.
• W2138065633 hasAuthorship W2138065633A5000741482 @default.
• W2138065633 hasAuthorship W2138065633A5052838486 @default.
• W2138065633 hasAuthorship W2138065633A5089253487 @default.
• W2138065633 hasBestOaLocation W21380656331 @default.
• W2138065633 hasConcept C104317684 @default.
• W2138065633 hasConcept C126322002 @default.
• W2138065633 hasConcept C128057223 @default.
• W2138065633 hasConcept C141105273 @default.
• W2138065633 hasConcept C153911025 @default.
• W2138065633 hasConcept C159654299 @default.
• W2138065633 hasConcept C17991360 @default.
• W2138065633 hasConcept C181901479 @default.
• W2138065633 hasConcept C185592680 @default.
• W2138065633 hasConcept C189938988 @default.
• W2138065633 hasConcept C191732599 @default.
• W2138065633 hasConcept C203014093 @default.
• W2138065633 hasConcept C2776415932 @default.
• W2138065633 hasConcept C2778690821 @default.
• W2138065633 hasConcept C2911091166 @default.
• W2138065633 hasConcept C55493867 @default.
• W2138065633 hasConcept C62478195 @default.
• W2138065633 hasConcept C71924100 @default.
• W2138065633 hasConcept C74172505 @default.
• W2138065633 hasConcept C86803240 @default.
• W2138065633 hasConcept C98274493 @default.
• W2138065633 hasConceptScore W2138065633C104317684 @default.
• W2138065633 hasConceptScore W2138065633C126322002 @default.
• W2138065633 hasConceptScore W2138065633C128057223 @default.
• W2138065633 hasConceptScore W2138065633C141105273 @default.
• W2138065633 hasConceptScore W2138065633C153911025 @default.
• W2138065633 hasConceptScore W2138065633C159654299 @default.
• W2138065633 hasConceptScore W2138065633C17991360 @default.
• W2138065633 hasConceptScore W2138065633C181901479 @default.
• W2138065633 hasConceptScore W2138065633C185592680 @default.
• W2138065633 hasConceptScore W2138065633C189938988 @default.
• W2138065633 hasConceptScore W2138065633C191732599 @default.
• W2138065633 hasConceptScore W2138065633C203014093 @default.
• W2138065633 hasConceptScore W2138065633C2776415932 @default.
• W2138065633 hasConceptScore W2138065633C2778690821 @default.
• W2138065633 hasConceptScore W2138065633C2911091166 @default.
• W2138065633 hasConceptScore W2138065633C55493867 @default.
• W2138065633 hasConceptScore W2138065633C62478195 @default.
• W2138065633 hasConceptScore W2138065633C71924100 @default.
• W2138065633 hasConceptScore W2138065633C74172505 @default.
• W2138065633 hasConceptScore W2138065633C86803240 @default.
• W2138065633 hasConceptScore W2138065633C98274493 @default.
• W2138065633 hasIssue "3" @default.
• W2138065633 hasLocation W21380656331 @default.
• W2138065633 hasOpenAccess W2138065633 @default.
• W2138065633 hasPrimaryLocation W21380656331 @default.
• W2138065633 hasRelatedWork W2023599848 @default.
• W2138065633 hasRelatedWork W2041967174 @default.

• next