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- W2138068075 abstract "Melon necrotic spot virus (MNSV) (genus Carmovirus, family Tombusviridae) is a single-stranded, positive-sense RNA virus that has become an experimental model for the analysis of cell-to-cell virus movement and translation of uncapped viral RNAs, whereas little is known about its replication. Analysis of the cytopathology after MNSV infection showed the specific presence of modified organelles that resemble mitochondria. Immunolocalization of the glycine decarboxylase complex (GDC) P protein in these organelles confirmed their mitochondrial origin. In situ hybridization and immunolocalization experiments showed the specific localization of positive-sense viral RNA, capsid protein (CP), and double-stranded (ds)RNA in these organelles meaning that replication of the virus takes place in association with them. The three-dimensional reconstructions of the altered mitochondria showed the presence of large, interconnected, internal dilations which appeared to be linked to the outside cytoplasmic environment through pores and/or complex structures, and with lipid bodies. Transient expression of MNSV p29 revealed that its specific target is mitochondria. Our data document the extensive reorganization of host mitochondria induced by MNSV, which provides a protected environment to viral replication, and show that the MNSV p29 protein is the primary determinant of this effect in the host." @default.
- W2138068075 created "2016-06-24" @default.
- W2138068075 creator A5008668762 @default.
- W2138068075 creator A5056622160 @default.
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- W2138068075 date "2015-04-01" @default.
- W2138068075 modified "2023-10-18" @default.
- W2138068075 title "<i>Melon necrotic spot virus</i> Replication Occurs in Association with Altered Mitochondria" @default.
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- W2138068075 doi "https://doi.org/10.1094/mpmi-09-14-0274-r" @default.
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