FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138077651> ?p ?o ?g. }

• W2138077651 endingPage "2515" @default.
• W2138077651 startingPage "2507" @default.
• W2138077651 abstract "Plasma sphingosine-1-phosphate (S1P) has been suggested to mainly originate from erythrocytes; however, within the erythrocyte, how sphingosine (SPH) generation--the precursor to S1P--is controlled is unknown. SPH is only generated from the hydrolysis of ceramides via ceramidases. Five human ceramidases have been identified: 1 acid, 1 neutral, and 3 alkaline ceramidases (ACER1, ACER2, and ACER3). Here, we demonstrate that only alkaline ceramidase activity is expressed in erythrocytes and that it is instrumental for SPH generation. Erythrocytes have alkaline but not acid or neutral ceramidase activity on D-e-C(18:1)-ceramide, a common substrate of ceramidases. Not only alkaline ceramidase activity but also the generation of SPH and S1P are increased during erythroid differentiation in K562 erythroleukemic cells. Such SPH and S1P increases were inhibited by the alkaline ceramidase inhibitor D-e-MAPP, suggesting that alkaline ceramidases have a role in the generation of SPH and S1P in erythroid cells. Alkaline ceramidase activity is highly expressed in mouse erythrocytes, and intravenous administration of D-e-MAPP decreased both SPH and S1P in erythrocytes and plasma. Collectively, these results suggest that alkaline ceramidase activity is important for the generation of SPH, the S1P precursor in erythrocytes." @default.
• W2138077651 created "2016-06-24" @default.
• W2138077651 creator A5023831938 @default.
• W2138077651 creator A5026542360 @default.
• W2138077651 creator A5044308307 @default.
• W2138077651 creator A5062601842 @default.
• W2138077651 creator A5084932247 @default.
• W2138077651 date "2010-03-05" @default.
• W2138077651 modified "2023-10-17" @default.
• W2138077651 title "Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes" @default.
• W2138077651 cites W1563659068 @default.
• W2138077651 cites W1574169977 @default.
• W2138077651 cites W1966929992 @default.
• W2138077651 cites W1973879230 @default.
• W2138077651 cites W198273110 @default.
• W2138077651 cites W1988204787 @default.
• W2138077651 cites W1993449698 @default.
• W2138077651 cites W2001867568 @default.
• W2138077651 cites W2007878869 @default.
• W2138077651 cites W2014923090 @default.
• W2138077651 cites W2015949769 @default.
• W2138077651 cites W2019209482 @default.
• W2138077651 cites W2019889454 @default.
• W2138077651 cites W2025191509 @default.
• W2138077651 cites W2032620622 @default.
• W2138077651 cites W2039321321 @default.
• W2138077651 cites W2039375023 @default.
• W2138077651 cites W2039820478 @default.
• W2138077651 cites W2046353286 @default.
• W2138077651 cites W2047231993 @default.
• W2138077651 cites W2049160111 @default.
• W2138077651 cites W2055816456 @default.
• W2138077651 cites W2062862555 @default.
• W2138077651 cites W2072227518 @default.
• W2138077651 cites W2076691840 @default.
• W2138077651 cites W2076829309 @default.
• W2138077651 cites W2077080612 @default.
• W2138077651 cites W2078702640 @default.
• W2138077651 cites W2084089752 @default.
• W2138077651 cites W2084537433 @default.
• W2138077651 cites W2090245512 @default.
• W2138077651 cites W2104063907 @default.
• W2138077651 cites W2106121689 @default.
• W2138077651 cites W2111191978 @default.
• W2138077651 cites W2112733125 @default.
• W2138077651 cites W2115137049 @default.
• W2138077651 cites W2118261235 @default.
• W2138077651 cites W2120908220 @default.
• W2138077651 cites W2234852071 @default.
• W2138077651 doi "https://doi.org/10.1096/fj.09-153635" @default.
• W2138077651 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2887272" @default.
• W2138077651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20207939" @default.
• W2138077651 hasPublicationYear "2010" @default.
• W2138077651 type Work @default.
• W2138077651 sameAs 2138077651 @default.
• W2138077651 citedByCount "38" @default.
• W2138077651 countsByYear W21380776512012 @default.
• W2138077651 countsByYear W21380776512013 @default.
• W2138077651 countsByYear W21380776512014 @default.
• W2138077651 countsByYear W21380776512015 @default.
• W2138077651 countsByYear W21380776512016 @default.
• W2138077651 countsByYear W21380776512017 @default.
• W2138077651 countsByYear W21380776512018 @default.
• W2138077651 countsByYear W21380776512019 @default.
• W2138077651 countsByYear W21380776512020 @default.
• W2138077651 countsByYear W21380776512021 @default.
• W2138077651 countsByYear W21380776512022 @default.
• W2138077651 countsByYear W21380776512023 @default.
• W2138077651 crossrefType "journal-article" @default.
• W2138077651 hasAuthorship W2138077651A5023831938 @default.
• W2138077651 hasAuthorship W2138077651A5026542360 @default.
• W2138077651 hasAuthorship W2138077651A5044308307 @default.
• W2138077651 hasAuthorship W2138077651A5062601842 @default.
• W2138077651 hasAuthorship W2138077651A5084932247 @default.
• W2138077651 hasBestOaLocation W21380776512 @default.
• W2138077651 hasConcept C170493617 @default.
• W2138077651 hasConcept C185592680 @default.
• W2138077651 hasConcept C190283241 @default.
• W2138077651 hasConcept C2776596873 @default.
• W2138077651 hasConcept C2777851122 @default.
• W2138077651 hasConcept C2778703144 @default.
• W2138077651 hasConcept C55493867 @default.
• W2138077651 hasConcept C61705674 @default.
• W2138077651 hasConceptScore W2138077651C170493617 @default.
• W2138077651 hasConceptScore W2138077651C185592680 @default.
• W2138077651 hasConceptScore W2138077651C190283241 @default.
• W2138077651 hasConceptScore W2138077651C2776596873 @default.
• W2138077651 hasConceptScore W2138077651C2777851122 @default.
• W2138077651 hasConceptScore W2138077651C2778703144 @default.
• W2138077651 hasConceptScore W2138077651C55493867 @default.
• W2138077651 hasConceptScore W2138077651C61705674 @default.
• W2138077651 hasFunder F4320332161 @default.
• W2138077651 hasIssue "7" @default.
• W2138077651 hasLocation W21380776511 @default.
• W2138077651 hasLocation W21380776512 @default.
• W2138077651 hasLocation W21380776513 @default.
• W2138077651 hasLocation W21380776514 @default.
• W2138077651 hasOpenAccess W2138077651 @default.

• next