FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138081191> ?p ?o ?g. }

• W2138081191 endingPage "1239" @default.
• W2138081191 startingPage "1229" @default.
• W2138081191 abstract "Background and Purpose —Because noninvasive physiological monitoring of cerebral blood flow, metabolic integrity, and brain ion and water homeostasis can now be accomplished with new, state-of-the-art MR spectroscopy and imaging techniques, it is appropriate to develop controllable and reproducible animal models that permit prolonged circulatory arrest and resuscitation in the magnet and also allow for studies of long-term survival and outcome. We have developed such a model in rats that involves minimal surgical preparations and can achieve resuscitation remotely within precisely controlled time. Methods —Cardiac arrest was induced by asphyxiation, the duration of which ranged from 8 to 24 minutes. Resuscitation was achieved remotely by a slow, intra-aortic infusion of oxygenated blood (withdrawn either from the same rat before asphyxia or from a healthy donor rat) along with a resuscitation cocktail containing heparin (50 U/100 g), sodium bicarbonate (0.1 mEq/100 g), and epinephrine (4 μg/100 g). The body temperature was measured by a tympanic thermocouple probe and was controlled either by a heating pad (constant tympanic temperature=37°C) or by warm ambient air (constant air temperature=37°C). Interleaved 31 P/ 1 H nuclear magnetic resonance (NMR) spectroscopy was used in a selected group of rats to measure the cerebral metabolism before and during approximately 20 minutes of circulatory arrest and after resuscitation. Results —The overall success rate of resuscitation, irrespective of the duration of cardiac arrest, was 82% (51 of 62). With a programmed infusion pump, the success rate was even higher (95%). The survival time for rats subjected to 15 and 19 minutes of asphyxia with core temperature tightly controlled was significantly lower than that with ambient temperature control ( P <0.001 and P <0.04, respectively). High-quality NMR spectra can be obtained continuously without interference from the resuscitation effort. Final histological examinations taken 5 days after resuscitation showed typical neuronal damages, similar to those found in other global ischemia models. Conclusions —Because the no-flow time and resuscitation time can be precisely controlled, this outcome model is ideally suited for studies of ischemic and reperfusion injuries in the brain and possibly in other critical organs, permitting continuous assessment of long-term recovery and follow-up in the same animals." @default.
• W2138081191 created "2016-06-24" @default.
• W2138081191 creator A5002782232 @default.
• W2138081191 creator A5017520377 @default.
• W2138081191 creator A5031605568 @default.
• W2138081191 creator A5038991494 @default.
• W2138081191 date "1998-06-01" @default.
• W2138081191 modified "2023-10-11" @default.
• W2138081191 title "A Reproducible Model of Circulatory Arrest and Remote Resuscitation in Rats for NMR Investigation" @default.
• W2138081191 cites W1969975325 @default.
• W2138081191 cites W1975521354 @default.
• W2138081191 cites W1978571932 @default.
• W2138081191 cites W1980573311 @default.
• W2138081191 cites W1983534157 @default.
• W2138081191 cites W1984645489 @default.
• W2138081191 cites W1986109902 @default.
• W2138081191 cites W1998827607 @default.
• W2138081191 cites W2001336547 @default.
• W2138081191 cites W2003493743 @default.
• W2138081191 cites W2003802096 @default.
• W2138081191 cites W2007985694 @default.
• W2138081191 cites W2008483626 @default.
• W2138081191 cites W2010553668 @default.
• W2138081191 cites W2013165626 @default.
• W2138081191 cites W2016597337 @default.
• W2138081191 cites W2017935064 @default.
• W2138081191 cites W2020362442 @default.
• W2138081191 cites W2022593257 @default.
• W2138081191 cites W2024765344 @default.
• W2138081191 cites W2043151182 @default.
• W2138081191 cites W2051251403 @default.
• W2138081191 cites W2058018167 @default.
• W2138081191 cites W2065277076 @default.
• W2138081191 cites W2076780322 @default.
• W2138081191 cites W2081062129 @default.
• W2138081191 cites W2084055869 @default.
• W2138081191 cites W2084917893 @default.
• W2138081191 cites W2085031640 @default.
• W2138081191 cites W2090040273 @default.
• W2138081191 cites W2090425137 @default.
• W2138081191 cites W2097921483 @default.
• W2138081191 cites W2098877347 @default.
• W2138081191 cites W2108998473 @default.
• W2138081191 cites W2115799281 @default.
• W2138081191 cites W2119034481 @default.
• W2138081191 cites W2142076308 @default.
• W2138081191 cites W2149953389 @default.
• W2138081191 cites W2159314344 @default.
• W2138081191 cites W3132336751 @default.
• W2138081191 doi "https://doi.org/10.1161/01.str.29.6.1229" @default.
• W2138081191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9626299" @default.
• W2138081191 hasPublicationYear "1998" @default.
• W2138081191 type Work @default.
• W2138081191 sameAs 2138081191 @default.
• W2138081191 citedByCount "39" @default.
• W2138081191 countsByYear W21380811912012 @default.
• W2138081191 countsByYear W21380811912013 @default.
• W2138081191 countsByYear W21380811912014 @default.
• W2138081191 countsByYear W21380811912015 @default.
• W2138081191 countsByYear W21380811912017 @default.
• W2138081191 countsByYear W21380811912018 @default.
• W2138081191 countsByYear W21380811912019 @default.
• W2138081191 countsByYear W21380811912020 @default.
• W2138081191 countsByYear W21380811912022 @default.
• W2138081191 countsByYear W21380811912023 @default.
• W2138081191 crossrefType "journal-article" @default.
• W2138081191 hasAuthorship W2138081191A5002782232 @default.
• W2138081191 hasAuthorship W2138081191A5017520377 @default.
• W2138081191 hasAuthorship W2138081191A5031605568 @default.
• W2138081191 hasAuthorship W2138081191A5038991494 @default.
• W2138081191 hasBestOaLocation W21380811911 @default.
• W2138081191 hasConcept C126322002 @default.
• W2138081191 hasConcept C158846371 @default.
• W2138081191 hasConcept C2775859304 @default.
• W2138081191 hasConcept C2777055891 @default.
• W2138081191 hasConcept C2778165595 @default.
• W2138081191 hasConcept C2778619729 @default.
• W2138081191 hasConcept C2779914510 @default.
• W2138081191 hasConcept C42219234 @default.
• W2138081191 hasConcept C71924100 @default.
• W2138081191 hasConcept C72859922 @default.
• W2138081191 hasConceptScore W2138081191C126322002 @default.
• W2138081191 hasConceptScore W2138081191C158846371 @default.
• W2138081191 hasConceptScore W2138081191C2775859304 @default.
• W2138081191 hasConceptScore W2138081191C2777055891 @default.
• W2138081191 hasConceptScore W2138081191C2778165595 @default.
• W2138081191 hasConceptScore W2138081191C2778619729 @default.
• W2138081191 hasConceptScore W2138081191C2779914510 @default.
• W2138081191 hasConceptScore W2138081191C42219234 @default.
• W2138081191 hasConceptScore W2138081191C71924100 @default.
• W2138081191 hasConceptScore W2138081191C72859922 @default.
• W2138081191 hasIssue "6" @default.
• W2138081191 hasLocation W21380811911 @default.
• W2138081191 hasLocation W21380811912 @default.
• W2138081191 hasOpenAccess W2138081191 @default.
• W2138081191 hasPrimaryLocation W21380811911 @default.
• W2138081191 hasRelatedWork W2029829369 @default.
• W2138081191 hasRelatedWork W2082118526 @default.

• next