FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138081307> ?p ?o ?g. }

• W2138081307 endingPage "946" @default.
• W2138081307 startingPage "939" @default.
• W2138081307 abstract "Background Allergic contact dermatitis (ACD) is a manifestation of a cell-mediated immune response, but its mechanism remains unknown. Recently, we investigated whether ACD involves various neuropeptides. Substance P (SP) is a neuropeptide that is known to act as a neurokinin receptor when the immune response is initiated. Calcitonin gene-related peptide (CGRP) is a distinct typical neuropeptide and, with SP, induces the immune response. Neuropeptides in neurogenic inflammation are regulated by the inactivation of receptors and enzymes that can cause neuropeptide degradation (e.g. angiotensin-converting enzyme [ACE]), but no enzyme that can degrade SP and CGRP has yet been reported. Methods We investigated changes in the expression of SP and CGRP, as representative of typical neuropeptides, in ACD skin in mouse and human and the effect of ACE expression on the degradation of these neuropeptides using reverse transcription polymerase chain reaction and immunoblot assay. We also examined the relationship between ACD and neuropeptides in skin tissue from human ACD subjects and mice with induced ACD by analyzing cytokine expression and the results of hematoxylin and eosin staining and immunofluorescence assay. Results Expression of SP, CGRP, and ACE was higher in skin tissues from animals with acute ACD than in normal animal skin. However, CGRP expression in human skin with acute ACD was lower than in normal skin, unlike expression of SP and ACE, both of which were higher in ACD human skin than in normal human skin. Conclusions We found different patterns of neuropeptide expression in human versus mouse skin. These neuropeptide activities were influenced by an increase in neuropeptide degrading enzymes. Our findings show that when SP is produced, expression of CGRP is suppressed in human skin with ACD. The reduction of CGRP expression in patients with acute ACD is caused by mast cells activated by SP." @default.
• W2138081307 created "2016-06-24" @default.
• W2138081307 creator A5000124096 @default.
• W2138081307 creator A5019394750 @default.
• W2138081307 creator A5024316673 @default.
• W2138081307 creator A5030337320 @default.
• W2138081307 creator A5034536686 @default.
• W2138081307 creator A5040256630 @default.
• W2138081307 creator A5065384951 @default.
• W2138081307 date "2012-07-12" @default.
• W2138081307 modified "2023-10-16" @default.
• W2138081307 title "A comparison of neuropeptide expression in skin with allergic contact dermatitis in human and mouse" @default.
• W2138081307 cites W1968736314 @default.
• W2138081307 cites W1969440846 @default.
• W2138081307 cites W1978641660 @default.
• W2138081307 cites W1983798395 @default.
• W2138081307 cites W1986228066 @default.
• W2138081307 cites W2014705617 @default.
• W2138081307 cites W2028834383 @default.
• W2138081307 cites W2034694041 @default.
• W2138081307 cites W2042144868 @default.
• W2138081307 cites W2045859101 @default.
• W2138081307 cites W2048898417 @default.
• W2138081307 cites W2052965227 @default.
• W2138081307 cites W2067417043 @default.
• W2138081307 cites W2082816999 @default.
• W2138081307 cites W2105464073 @default.
• W2138081307 cites W2124000778 @default.
• W2138081307 cites W2124566538 @default.
• W2138081307 cites W2132709814 @default.
• W2138081307 cites W2262747944 @default.
• W2138081307 cites W4300467547 @default.
• W2138081307 doi "https://doi.org/10.1111/j.1365-4632.2011.05197.x" @default.
• W2138081307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22788810" @default.
• W2138081307 hasPublicationYear "2012" @default.
• W2138081307 type Work @default.
• W2138081307 sameAs 2138081307 @default.
• W2138081307 citedByCount "3" @default.
• W2138081307 countsByYear W21380813072013 @default.
• W2138081307 countsByYear W21380813072016 @default.
• W2138081307 countsByYear W21380813072019 @default.
• W2138081307 crossrefType "journal-article" @default.
• W2138081307 hasAuthorship W2138081307A5000124096 @default.
• W2138081307 hasAuthorship W2138081307A5019394750 @default.
• W2138081307 hasAuthorship W2138081307A5024316673 @default.
• W2138081307 hasAuthorship W2138081307A5030337320 @default.
• W2138081307 hasAuthorship W2138081307A5034536686 @default.
• W2138081307 hasAuthorship W2138081307A5040256630 @default.
• W2138081307 hasAuthorship W2138081307A5065384951 @default.
• W2138081307 hasConcept C118303440 @default.
• W2138081307 hasConcept C126322002 @default.
• W2138081307 hasConcept C134018914 @default.
• W2138081307 hasConcept C137130169 @default.
• W2138081307 hasConcept C163170386 @default.
• W2138081307 hasConcept C170493617 @default.
• W2138081307 hasConcept C203014093 @default.
• W2138081307 hasConcept C2776089194 @default.
• W2138081307 hasConcept C2776533618 @default.
• W2138081307 hasConcept C2777459323 @default.
• W2138081307 hasConcept C2779627488 @default.
• W2138081307 hasConcept C54355233 @default.
• W2138081307 hasConcept C71924100 @default.
• W2138081307 hasConcept C86803240 @default.
• W2138081307 hasConcept C8891405 @default.
• W2138081307 hasConcept C93984277 @default.
• W2138081307 hasConceptScore W2138081307C118303440 @default.
• W2138081307 hasConceptScore W2138081307C126322002 @default.
• W2138081307 hasConceptScore W2138081307C134018914 @default.
• W2138081307 hasConceptScore W2138081307C137130169 @default.
• W2138081307 hasConceptScore W2138081307C163170386 @default.
• W2138081307 hasConceptScore W2138081307C170493617 @default.
• W2138081307 hasConceptScore W2138081307C203014093 @default.
• W2138081307 hasConceptScore W2138081307C2776089194 @default.
• W2138081307 hasConceptScore W2138081307C2776533618 @default.
• W2138081307 hasConceptScore W2138081307C2777459323 @default.
• W2138081307 hasConceptScore W2138081307C2779627488 @default.
• W2138081307 hasConceptScore W2138081307C54355233 @default.
• W2138081307 hasConceptScore W2138081307C71924100 @default.
• W2138081307 hasConceptScore W2138081307C86803240 @default.
• W2138081307 hasConceptScore W2138081307C8891405 @default.
• W2138081307 hasConceptScore W2138081307C93984277 @default.
• W2138081307 hasIssue "8" @default.
• W2138081307 hasLocation W21380813071 @default.
• W2138081307 hasLocation W21380813072 @default.
• W2138081307 hasOpenAccess W2138081307 @default.
• W2138081307 hasPrimaryLocation W21380813071 @default.
• W2138081307 hasRelatedWork W173300921 @default.
• W2138081307 hasRelatedWork W1943192612 @default.
• W2138081307 hasRelatedWork W1974150707 @default.
• W2138081307 hasRelatedWork W1974775584 @default.
• W2138081307 hasRelatedWork W1990739055 @default.
• W2138081307 hasRelatedWork W1999176154 @default.
• W2138081307 hasRelatedWork W2002135262 @default.
• W2138081307 hasRelatedWork W2003450342 @default.
• W2138081307 hasRelatedWork W2138081307 @default.
• W2138081307 hasRelatedWork W2147121262 @default.
• W2138081307 hasVolume "51" @default.
• W2138081307 isParatext "false" @default.

• next