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• W2138150103 abstract "ATP-driven proteolysis plays a major role in regulating the bacterial cell cycle, development and stress responses. In the nitro -fixing symbiosis with host plants, Sinorhizobium meliloti undergoes a profound cellular differentiation, including endoreduplication of the ome. The regulatory mechanisms governing the alterations of the S. meliloti cell cycle in planta are largely unknown. Here, we report the characterization of two cpdR homologues, cpdR1 and cpdR2, of S. meliloti that encode single-domain response regulators. In Caulobacter crescentus, CpdR controls the polar localization of the ClpXP protease, thereby mediating the regulated proteolysis of key protein(s), such as CtrA, involved in cell cycle progression. The S. meliloti cpdR1-null mutant can invade the host cytoplasm, however, the intracellular bacteria are unable to differentiate into bacteroids. We show that S. meliloti CpdR1 has a polar localization pattern and a role in ClpX positioning similar to C. crescentus CpdR, suggesting a conserved function of CpdR proteins among alpha-proteobacteria. However, in S. meliloti, free-living cells of the cpdR1-null mutant show a striking morphology of irregular coccoids and aberrant DNA replication. Thus, we demonstrate that CpdR1 mediates the co-ordination of cell cycle events, which are critical for both the free-living cell division and the differentiation required for the chronic intracellular infection." @default.
• W2138150103 created "2016-06-24" @default.
• W2138150103 creator A5003448058 @default.
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• W2138150103 creator A5055247607 @default.
• W2138150103 creator A5075657088 @default.
• W2138150103 creator A5090953868 @default.
• W2138150103 date "2009-08-01" @default.
• W2138150103 modified "2023-10-01" @default.
• W2138150103 title "<i>Sinorhizobium meliloti</i>CpdR1 is critical for co-ordinating cell cycle progression and the symbiotic chronic infection" @default.
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• W2138150103 doi "https://doi.org/10.1111/j.1365-2958.2009.06794.x" @default.
• W2138150103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2756024" @default.
• W2138150103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19602145" @default.
• W2138150103 hasPublicationYear "2009" @default.
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