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• W2138155997 abstract "Amyloid precursor protein (APP), implicated in Alzheimer's disease, is a trans-membrane protein of undetermined function. APP is cleaved by γ-secretase that releases the APP intracellular domain (AICD) in the cytoplasm. In vitro studies have implicated AICD in cell signaling and transcriptional regulation, but its biologic relevance has been uncertain and its in vivo function has not been examined. To investigate its functional role, we generated AICD transgenic mice, and found that AICD causes significant biologic changes in vivo. AICD transgenic mice show activation of glycogen synthase kinase-3β (GSK-3β) and phosphorylation of CRMP2 protein, a GSK-3β substrate that plays a crucial role in Semaphorin3a-mediated axonal guidance. Our data suggest that AICD is biologically relevant, causes significant alterations in cell signaling, and may play a role in axonal elongation or pathfinding." @default.
• W2138155997 created "2016-06-24" @default.
• W2138155997 creator A5017178370 @default.
• W2138155997 creator A5070702974 @default.
• W2138155997 date "2005-10-17" @default.
• W2138155997 modified "2023-10-14" @default.
• W2138155997 title "Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain" @default.
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• W2138155997 doi "https://doi.org/10.1083/jcb.200505078" @default.
• W2138155997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2171208" @default.
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