FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138156710> ?p ?o ?g. }

• W2138156710 endingPage "1340" @default.
• W2138156710 startingPage "1329" @default.
• W2138156710 abstract "The c-Jun NH(2)-terminal kinase (JNK) is implicated in proliferation. Mice with a deficiency of either the Jnk1 or the Jnk2 genes are viable, but a compound deficiency of both Jnk1 and Jnk2 causes early embryonic lethality. Studies using conditional gene ablation and chemical genetic approaches demonstrate that the combined loss of JNK1 and JNK2 protein kinase function results in rapid senescence. To test whether this role of JNK was required for stem cell proliferation, we isolated embryonic stem (ES) cells from wild-type and JNK-deficient mice. We found that Jnk1(-/-) Jnk2(-/-) ES cells underwent self-renewal, but these cells proliferated more rapidly than wild-type ES cells and exhibited major defects in lineage-specific differentiation. Together, these data demonstrate that JNK is not required for proliferation or self-renewal of ES cells, but JNK plays a key role in the differentiation of ES cells." @default.
• W2138156710 created "2016-06-24" @default.
• W2138156710 creator A5033012006 @default.
• W2138156710 creator A5056045882 @default.
• W2138156710 date "2010-03-01" @default.
• W2138156710 modified "2023-09-30" @default.
• W2138156710 title "c-Jun NH₂-Terminal Kinase Is Required for Lineage-Specific Differentiation but Not Stem Cell Self-Renewal" @default.
• W2138156710 cites W1809585889 @default.
• W2138156710 cites W1834912150 @default.
• W2138156710 cites W1925655957 @default.
• W2138156710 cites W1967838149 @default.
• W2138156710 cites W1974634929 @default.
• W2138156710 cites W1977158079 @default.
• W2138156710 cites W1982499214 @default.
• W2138156710 cites W1984885474 @default.
• W2138156710 cites W1988008469 @default.
• W2138156710 cites W1995648202 @default.
• W2138156710 cites W2000241541 @default.
• W2138156710 cites W2004550343 @default.
• W2138156710 cites W2008948574 @default.
• W2138156710 cites W2009572451 @default.
• W2138156710 cites W2010710751 @default.
• W2138156710 cites W2011437456 @default.
• W2138156710 cites W2025172485 @default.
• W2138156710 cites W2025239125 @default.
• W2138156710 cites W2030071293 @default.
• W2138156710 cites W2032867856 @default.
• W2138156710 cites W2035967893 @default.
• W2138156710 cites W2036055444 @default.
• W2138156710 cites W2038215157 @default.
• W2138156710 cites W2040532363 @default.
• W2138156710 cites W2048732846 @default.
• W2138156710 cites W2053560001 @default.
• W2138156710 cites W2054963713 @default.
• W2138156710 cites W2055156816 @default.
• W2138156710 cites W2057375692 @default.
• W2138156710 cites W2063208932 @default.
• W2138156710 cites W2064079081 @default.
• W2138156710 cites W2064586774 @default.
• W2138156710 cites W2065788477 @default.
• W2138156710 cites W2067427748 @default.
• W2138156710 cites W2070330987 @default.
• W2138156710 cites W2075084906 @default.
• W2138156710 cites W2076485183 @default.
• W2138156710 cites W2083625284 @default.
• W2138156710 cites W2086402424 @default.
• W2138156710 cites W2100835162 @default.
• W2138156710 cites W2106000284 @default.
• W2138156710 cites W2111428392 @default.
• W2138156710 cites W2112431248 @default.
• W2138156710 cites W2113724972 @default.
• W2138156710 cites W2114125896 @default.
• W2138156710 cites W2114647473 @default.
• W2138156710 cites W2115962469 @default.
• W2138156710 cites W2119807130 @default.
• W2138156710 cites W2135801344 @default.
• W2138156710 cites W2136059817 @default.
• W2138156710 cites W2142205521 @default.
• W2138156710 cites W2146035452 @default.
• W2138156710 cites W2148354523 @default.
• W2138156710 cites W2148479228 @default.
• W2138156710 cites W2159788195 @default.
• W2138156710 cites W2170560537 @default.
• W2138156710 cites W2170748292 @default.
• W2138156710 cites W2171317581 @default.
• W2138156710 doi "https://doi.org/10.1128/mcb.00795-09" @default.
• W2138156710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2832508" @default.
• W2138156710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20065035" @default.
• W2138156710 hasPublicationYear "2010" @default.
• W2138156710 type Work @default.
• W2138156710 sameAs 2138156710 @default.
• W2138156710 citedByCount "46" @default.
• W2138156710 countsByYear W21381567102012 @default.
• W2138156710 countsByYear W21381567102013 @default.
• W2138156710 countsByYear W21381567102014 @default.
• W2138156710 countsByYear W21381567102015 @default.
• W2138156710 countsByYear W21381567102016 @default.
• W2138156710 countsByYear W21381567102017 @default.
• W2138156710 countsByYear W21381567102018 @default.
• W2138156710 countsByYear W21381567102019 @default.
• W2138156710 countsByYear W21381567102020 @default.
• W2138156710 countsByYear W21381567102021 @default.
• W2138156710 crossrefType "journal-article" @default.
• W2138156710 hasAuthorship W2138156710A5033012006 @default.
• W2138156710 hasAuthorship W2138156710A5056045882 @default.
• W2138156710 hasBestOaLocation W21381567101 @default.
• W2138156710 hasConcept C104317684 @default.
• W2138156710 hasConcept C145103041 @default.
• W2138156710 hasConcept C148738053 @default.
• W2138156710 hasConcept C153911025 @default.
• W2138156710 hasConcept C184235292 @default.
• W2138156710 hasConcept C2779087070 @default.
• W2138156710 hasConcept C28328180 @default.
• W2138156710 hasConcept C54355233 @default.
• W2138156710 hasConcept C62112901 @default.
• W2138156710 hasConcept C86339819 @default.
• W2138156710 hasConcept C86803240 @default.
• W2138156710 hasConcept C95444343 @default.

• next