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• W2138192231 endingPage "25" @default.
• W2138192231 startingPage "1" @default.
• W2138192231 abstract "Most acute and chronic neurodegenerative conditions are accompanied by neuroinflammation; yet the exact nature of the inflammatory processes and whether they modify disease progression is not well understood. In this review, we discuss the key epidemiological, clinical, and experimental evidence implicating inflammatory processes in the progressive degeneration of the dopaminergic (DA) nigrostriatal pathway and their potential contribution to the pathophysiology of Parkinson's disease (PD). Given that interplay between genetics and environment are likely to contribute to risk for development of idiopathic PD, recent data showing interactions between products of genes linked to heritable PD that function to protect DA neurons against oxidative or proteolytic stress and inflammation pathways will be discussed. Cellular mechanisms activated or enhanced by inflammatory processes that may contribute to mitochondrial dysfunction, oxidative stress, or apoptosis of dopaminergic (DA) neurons will be reviewed, with special emphasis on tumor necrosis factor (TNF) and interleukin-1-beta (IL-1beta) signaling pathways. Epigenetic factors which have the potential to trigger neuroinflammation, including environmental exposures and age-associated chronic inflammatory conditions, will be discussed as possible 'second-hit' triggers that may affect disease onset or progression of idiopathic PD. If inflammatory processes have an active role in nigrostriatal pathway degeneration, then evidence should exist to indicate that such processes begin in the early stages of disease and that they contribute to neuronal dysfunction and/or hasten neurodegeneration of the nigrostriatal pathway. Therapeutically, if anti-inflammatory interventions can be shown to rescue nigral DA neurons from degeneration and lower PD risk, then timely use of anti-inflammatory therapies should be investigated further in well-designed clinical trials for their ability to prevent or delay the progressive loss of nigral DA neurons in genetically susceptible populations." @default.
• W2138192231 created "2016-06-24" @default.
• W2138192231 creator A5008036209 @default.
• W2138192231 creator A5014253449 @default.
• W2138192231 creator A5062738955 @default.
• W2138192231 date "2007-11-01" @default.
• W2138192231 modified "2023-10-01" @default.
• W2138192231 title "Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention" @default.
• W2138192231 cites W117797836 @default.
• W2138192231 cites W1489699963 @default.
• W2138192231 cites W1490899177 @default.
• W2138192231 cites W1491611834 @default.
• W2138192231 cites W1504584187 @default.
• W2138192231 cites W1514224413 @default.
• W2138192231 cites W152231878 @default.
• W2138192231 cites W1530199299 @default.
• W2138192231 cites W1534435233 @default.
• W2138192231 cites W1535056291 @default.
• W2138192231 cites W1544085379 @default.
• W2138192231 cites W1545110321 @default.
• W2138192231 cites W1563090311 @default.
• W2138192231 cites W1577637371 @default.
• W2138192231 cites W1578813045 @default.
• W2138192231 cites W1580441010 @default.
• W2138192231 cites W1584876723 @default.
• W2138192231 cites W1585782290 @default.
• W2138192231 cites W1587360940 @default.
• W2138192231 cites W1630502818 @default.
• W2138192231 cites W1642457845 @default.
• W2138192231 cites W1670573097 @default.
• W2138192231 cites W17149418 @default.
• W2138192231 cites W175181244 @default.
• W2138192231 cites W1877873625 @default.
• W2138192231 cites W1891591278 @default.
• W2138192231 cites W1891696008 @default.
• W2138192231 cites W1900066504 @default.
• W2138192231 cites W1900846504 @default.
• W2138192231 cites W1930159471 @default.
• W2138192231 cites W1944984946 @default.
• W2138192231 cites W1954514489 @default.
• W2138192231 cites W1960100142 @default.
• W2138192231 cites W1963626598 @default.
• W2138192231 cites W1965698172 @default.
• W2138192231 cites W1966218771 @default.
• W2138192231 cites W1966437242 @default.
• W2138192231 cites W1966905916 @default.
• W2138192231 cites W1967893879 @default.
• W2138192231 cites W1967985820 @default.
• W2138192231 cites W1968427910 @default.
• W2138192231 cites W1968666033 @default.
• W2138192231 cites W1969125125 @default.
• W2138192231 cites W1969185518 @default.
• W2138192231 cites W1969280474 @default.
• W2138192231 cites W1969685242 @default.
• W2138192231 cites W1970626005 @default.
• W2138192231 cites W1971200109 @default.
• W2138192231 cites W1971776963 @default.
• W2138192231 cites W1974924674 @default.
• W2138192231 cites W1976412728 @default.
• W2138192231 cites W1976897228 @default.
• W2138192231 cites W1977225705 @default.
• W2138192231 cites W1977604451 @default.
• W2138192231 cites W1978296435 @default.
• W2138192231 cites W1978525572 @default.
• W2138192231 cites W1979480763 @default.
• W2138192231 cites W1980845575 @default.
• W2138192231 cites W1982177950 @default.
• W2138192231 cites W1982467499 @default.
• W2138192231 cites W1983591304 @default.
• W2138192231 cites W1983892290 @default.
• W2138192231 cites W1984940419 @default.
• W2138192231 cites W1985055167 @default.
• W2138192231 cites W1985628988 @default.
• W2138192231 cites W1986216002 @default.
• W2138192231 cites W1986827965 @default.
• W2138192231 cites W1990203556 @default.
• W2138192231 cites W1991805788 @default.
• W2138192231 cites W1992622318 @default.
• W2138192231 cites W1993753481 @default.
• W2138192231 cites W1994583626 @default.
• W2138192231 cites W1995069786 @default.
• W2138192231 cites W1995826981 @default.
• W2138192231 cites W1996024251 @default.
• W2138192231 cites W1996962549 @default.
• W2138192231 cites W1997124326 @default.
• W2138192231 cites W1997282323 @default.
• W2138192231 cites W1997326200 @default.
• W2138192231 cites W1998260405 @default.
• W2138192231 cites W1998596454 @default.
• W2138192231 cites W1998689099 @default.
• W2138192231 cites W1998693095 @default.
• W2138192231 cites W1999733628 @default.
• W2138192231 cites W1999922500 @default.
• W2138192231 cites W2000228066 @default.
• W2138192231 cites W2000942652 @default.
• W2138192231 cites W2001286956 @default.
• W2138192231 cites W2001408101 @default.
• W2138192231 cites W2001764336 @default.

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