FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138192752> ?p ?o ?g. }

• W2138192752 endingPage "54" @default.
• W2138192752 startingPage "349" @default.
• W2138192752 abstract "The therapeutic effect of dye compounds with antibacterial activity was evaluated in a silkworm model of Staphylococcus aureus infection. Among 13 chromogenic agents that show antibacterial activity against S. aureus (MIC = 0.02 to 19 μg/mL), rifampicin had a therapeutic effect. The ED(50) value in the silkworm model was consistent with that in a murine model. Other 12 dyes did not increase survival of the infected silkworms. We examined the reason for the lack of therapeutic efficacy. Amidol, pyronin G, and safranin were toxic to silkworms, which explained the lack of therapeutic effects. Fuchsin basic and methyl green disappeared quickly from the hemolymph after injection, suggesting that they are not stable in the hemolymph. Although coomassie brilliant blue R250/G250, cresyl blue, and nigrosin showed no toxic effects or instability in the hemolymph, they also did not have a therapeutic effect. The in vitro antibacterial actions of these dyes were inhibited by silkworm plasma or bovine serum albumin and filtration experiments demonstrated that cresyl blue bound to plasma proteins in the silkworm, suggesting that plasma protein binding inhibited the therapeutic efficacy of these four dyes. These findings indicate that drug screening using the silkworm infection model is useful for evaluating toxicity and pharmacokinetics of potential antibiotics." @default.
• W2138192752 created "2016-06-24" @default.
• W2138192752 creator A5003851517 @default.
• W2138192752 creator A5052625236 @default.
• W2138192752 creator A5061673601 @default.
• W2138192752 creator A5082378325 @default.
• W2138192752 date "2010-10-01" @default.
• W2138192752 modified "2023-10-03" @default.
• W2138192752 title "Evaluation of therapeutic effects and pharmacokinetics of antibacterial chromogenic agents in a silkworm model of Staphylococcus aureus infection." @default.
• W2138192752 cites W1531230592 @default.
• W2138192752 cites W187217045 @default.
• W2138192752 cites W1966490340 @default.
• W2138192752 cites W1990583552 @default.
• W2138192752 cites W1993378050 @default.
• W2138192752 cites W1993625807 @default.
• W2138192752 cites W1996431942 @default.
• W2138192752 cites W2017391093 @default.
• W2138192752 cites W2033288419 @default.
• W2138192752 cites W2036631837 @default.
• W2138192752 cites W2041092021 @default.
• W2138192752 cites W2067459912 @default.
• W2138192752 cites W207229365 @default.
• W2138192752 cites W2074811101 @default.
• W2138192752 cites W2082482229 @default.
• W2138192752 cites W2086088089 @default.
• W2138192752 cites W2104318703 @default.
• W2138192752 cites W2109642572 @default.
• W2138192752 cites W2111436063 @default.
• W2138192752 cites W2153920932 @default.
• W2138192752 cites W2160019687 @default.
• W2138192752 cites W2164640870 @default.
• W2138192752 cites W231790614 @default.
• W2138192752 cites W2517478732 @default.
• W2138192752 cites W2018211352 @default.
• W2138192752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22491238" @default.
• W2138192752 hasPublicationYear "2010" @default.
• W2138192752 type Work @default.
• W2138192752 sameAs 2138192752 @default.
• W2138192752 citedByCount "11" @default.
• W2138192752 countsByYear W21381927522012 @default.
• W2138192752 countsByYear W21381927522013 @default.
• W2138192752 countsByYear W21381927522014 @default.
• W2138192752 countsByYear W21381927522016 @default.
• W2138192752 countsByYear W21381927522017 @default.
• W2138192752 countsByYear W21381927522022 @default.
• W2138192752 crossrefType "journal-article" @default.
• W2138192752 hasAuthorship W2138192752A5003851517 @default.
• W2138192752 hasAuthorship W2138192752A5052625236 @default.
• W2138192752 hasAuthorship W2138192752A5061673601 @default.
• W2138192752 hasAuthorship W2138192752A5082378325 @default.
• W2138192752 hasConcept C100068826 @default.
• W2138192752 hasConcept C102652120 @default.
• W2138192752 hasConcept C112705442 @default.
• W2138192752 hasConcept C128463046 @default.
• W2138192752 hasConcept C185592680 @default.
• W2138192752 hasConcept C19831878 @default.
• W2138192752 hasConcept C2779489039 @default.
• W2138192752 hasConcept C2779740913 @default.
• W2138192752 hasConcept C2780035454 @default.
• W2138192752 hasConcept C2780104969 @default.
• W2138192752 hasConcept C2780761556 @default.
• W2138192752 hasConcept C43617362 @default.
• W2138192752 hasConcept C501593827 @default.
• W2138192752 hasConcept C523546767 @default.
• W2138192752 hasConcept C54355233 @default.
• W2138192752 hasConcept C55493867 @default.
• W2138192752 hasConcept C74864618 @default.
• W2138192752 hasConcept C86803240 @default.
• W2138192752 hasConcept C89423630 @default.
• W2138192752 hasConcept C98274493 @default.
• W2138192752 hasConceptScore W2138192752C100068826 @default.
• W2138192752 hasConceptScore W2138192752C102652120 @default.
• W2138192752 hasConceptScore W2138192752C112705442 @default.
• W2138192752 hasConceptScore W2138192752C128463046 @default.
• W2138192752 hasConceptScore W2138192752C185592680 @default.
• W2138192752 hasConceptScore W2138192752C19831878 @default.
• W2138192752 hasConceptScore W2138192752C2779489039 @default.
• W2138192752 hasConceptScore W2138192752C2779740913 @default.
• W2138192752 hasConceptScore W2138192752C2780035454 @default.
• W2138192752 hasConceptScore W2138192752C2780104969 @default.
• W2138192752 hasConceptScore W2138192752C2780761556 @default.
• W2138192752 hasConceptScore W2138192752C43617362 @default.
• W2138192752 hasConceptScore W2138192752C501593827 @default.
• W2138192752 hasConceptScore W2138192752C523546767 @default.
• W2138192752 hasConceptScore W2138192752C54355233 @default.
• W2138192752 hasConceptScore W2138192752C55493867 @default.
• W2138192752 hasConceptScore W2138192752C74864618 @default.
• W2138192752 hasConceptScore W2138192752C86803240 @default.
• W2138192752 hasConceptScore W2138192752C89423630 @default.
• W2138192752 hasConceptScore W2138192752C98274493 @default.
• W2138192752 hasIssue "5" @default.
• W2138192752 hasLocation W21381927521 @default.
• W2138192752 hasOpenAccess W2138192752 @default.
• W2138192752 hasPrimaryLocation W21381927521 @default.
• W2138192752 hasRelatedWork W1994996480 @default.
• W2138192752 hasRelatedWork W2138192752 @default.
• W2138192752 hasRelatedWork W2145406335 @default.
• W2138192752 hasRelatedWork W2295564308 @default.

• next