FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138227889> ?p ?o ?g. }

• W2138227889 endingPage "3008" @default.
• W2138227889 startingPage "3000" @default.
• W2138227889 abstract "ABSTRACT Water-forming NADH oxidases (encoded by noxE , nox2 , or nox ) are flavoproteins generally implicated in the aerobic survival of microaerophilic bacteria, such as lactic acid bacteria. However, some natural Lactococcus lactis strains produce an inactive NoxE. We examined the role of NoxE in the oxygen tolerance of L. lactis in the rich synthetic medium GM17. Inactivation of noxE suppressed 95% of NADH oxidase activity but only slightly affected aerobic growth, oxidative stress resistance, and NAD regeneration. However, noxE inactivation strongly impaired oxygen consumption and mixed-acid fermentation. We found that the A303T mutation is responsible for the loss of activity of a naturally occurring variant of NoxE. Replacement of A303 with T or G or of G307 with S or A by site-directed mutagenesis led to NoxE aggregation and the total loss of activity. We demonstrated that L299 is involved in NoxE activity, probably contributing to positioning flavin adenine dinucleotide (FAD) in the active site. These residues are part of the strongly conserved sequence LA(T)XXAXXXG included in an alpha helix that is present in other flavoprotein disulfide reductase (FDR) family flavoproteins that display very similar three-dimensional structures." @default.
• W2138227889 created "2016-06-24" @default.
• W2138227889 creator A5026366252 @default.
• W2138227889 creator A5038160401 @default.
• W2138227889 creator A5085143394 @default.
• W2138227889 date "2011-06-15" @default.
• W2138227889 modified "2023-09-26" @default.
• W2138227889 title "Identification of a Conserved Sequence in Flavoproteins Essential for the Correct Conformation and Activity of the NADH Oxidase NoxE of Lactococcus lactis" @default.
• W2138227889 cites W1491446302 @default.
• W2138227889 cites W1572879308 @default.
• W2138227889 cites W170417513 @default.
• W2138227889 cites W1970329923 @default.
• W2138227889 cites W1974572914 @default.
• W2138227889 cites W1975165965 @default.
• W2138227889 cites W1982943254 @default.
• W2138227889 cites W1989756890 @default.
• W2138227889 cites W1999623718 @default.
• W2138227889 cites W2000006549 @default.
• W2138227889 cites W2002789370 @default.
• W2138227889 cites W2003898032 @default.
• W2138227889 cites W2014343915 @default.
• W2138227889 cites W2014985621 @default.
• W2138227889 cites W2022405954 @default.
• W2138227889 cites W2024961386 @default.
• W2138227889 cites W2033345590 @default.
• W2138227889 cites W2047407002 @default.
• W2138227889 cites W2054328275 @default.
• W2138227889 cites W2061545094 @default.
• W2138227889 cites W2070720796 @default.
• W2138227889 cites W2075818588 @default.
• W2138227889 cites W2078928624 @default.
• W2138227889 cites W2079071998 @default.
• W2138227889 cites W2106418531 @default.
• W2138227889 cites W2109276669 @default.
• W2138227889 cites W2114584158 @default.
• W2138227889 cites W2124765964 @default.
• W2138227889 cites W2129637518 @default.
• W2138227889 cites W2132631210 @default.
• W2138227889 cites W2134193784 @default.
• W2138227889 cites W2140137672 @default.
• W2138227889 cites W2143240949 @default.
• W2138227889 cites W2159342900 @default.
• W2138227889 cites W2161213898 @default.
• W2138227889 cites W2166196545 @default.
• W2138227889 cites W4206694472 @default.
• W2138227889 cites W4293247451 @default.
• W2138227889 doi "https://doi.org/10.1128/jb.01466-10" @default.
• W2138227889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3133199" @default.
• W2138227889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21498647" @default.
• W2138227889 hasPublicationYear "2011" @default.
• W2138227889 type Work @default.
• W2138227889 sameAs 2138227889 @default.
• W2138227889 citedByCount "18" @default.
• W2138227889 countsByYear W21382278892013 @default.
• W2138227889 countsByYear W21382278892014 @default.
• W2138227889 countsByYear W21382278892015 @default.
• W2138227889 countsByYear W21382278892018 @default.
• W2138227889 countsByYear W21382278892019 @default.
• W2138227889 countsByYear W21382278892020 @default.
• W2138227889 countsByYear W21382278892022 @default.
• W2138227889 countsByYear W21382278892023 @default.
• W2138227889 crossrefType "journal-article" @default.
• W2138227889 hasAuthorship W2138227889A5026366252 @default.
• W2138227889 hasAuthorship W2138227889A5038160401 @default.
• W2138227889 hasAuthorship W2138227889A5085143394 @default.
• W2138227889 hasBestOaLocation W21382278891 @default.
• W2138227889 hasConcept C104317684 @default.
• W2138227889 hasConcept C134651460 @default.
• W2138227889 hasConcept C16318435 @default.
• W2138227889 hasConcept C181199279 @default.
• W2138227889 hasConcept C197957613 @default.
• W2138227889 hasConcept C2775859393 @default.
• W2138227889 hasConcept C2775920511 @default.
• W2138227889 hasConcept C2780011460 @default.
• W2138227889 hasConcept C33093398 @default.
• W2138227889 hasConcept C38485361 @default.
• W2138227889 hasConcept C501734568 @default.
• W2138227889 hasConcept C523546767 @default.
• W2138227889 hasConcept C54355233 @default.
• W2138227889 hasConcept C55493867 @default.
• W2138227889 hasConcept C71995715 @default.
• W2138227889 hasConcept C75520062 @default.
• W2138227889 hasConcept C86803240 @default.
• W2138227889 hasConceptScore W2138227889C104317684 @default.
• W2138227889 hasConceptScore W2138227889C134651460 @default.
• W2138227889 hasConceptScore W2138227889C16318435 @default.
• W2138227889 hasConceptScore W2138227889C181199279 @default.
• W2138227889 hasConceptScore W2138227889C197957613 @default.
• W2138227889 hasConceptScore W2138227889C2775859393 @default.
• W2138227889 hasConceptScore W2138227889C2775920511 @default.
• W2138227889 hasConceptScore W2138227889C2780011460 @default.
• W2138227889 hasConceptScore W2138227889C33093398 @default.
• W2138227889 hasConceptScore W2138227889C38485361 @default.
• W2138227889 hasConceptScore W2138227889C501734568 @default.
• W2138227889 hasConceptScore W2138227889C523546767 @default.
• W2138227889 hasConceptScore W2138227889C54355233 @default.
• W2138227889 hasConceptScore W2138227889C55493867 @default.
• W2138227889 hasConceptScore W2138227889C71995715 @default.

• next