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- W2138236516 abstract "Low density lipoprotein (LDL) oxidation mediated by phorbol myristate acetate (PMA)- and formylmethionylleucylphenylalanine (FMLP) -stimulated human neutrophils was enhanced by 70% in the presence of ferritin. Iron released from ferritin by the superoxide anion generated in the respiratory burst of stimulated neutrophils is shown to be involved in lipoprotein oxidation. Ascorbate (100 μml), superoxide dismutase (10 μg/ml) and uric acid (430 μM) showed inhibitory effects of 10%, 70% and 50% on LDL oxidation, respectively. Ceruloplasmin (2.7 μM) potentiated LDL oxidation by stimulated neutrophils and ferritin, both alone and in the presence of methionine. Methionine (1 mM) and catalase (30 μg/ml) increased LDL oxidation by stimulated neutrophils and ferritin. These data suggest that LDL oxidation by stimulated neutrophils and ferritin may be relevant in inflammation when both neutrophils and ferritin are increased." @default.
- W2138236516 created "2016-06-24" @default.
- W2138236516 creator A5008876378 @default.
- W2138236516 creator A5031703106 @default.
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- W2138236516 date "1992-12-01" @default.
- W2138236516 modified "2023-09-23" @default.
- W2138236516 title "Low density lipoprotein oxidation by stimulated neutrophils and ferritin" @default.
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- W2138236516 doi "https://doi.org/10.1016/0021-9150(92)90128-4" @default.
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