Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138241311> ?p ?o ?g. }
- W2138241311 endingPage "11968" @default.
- W2138241311 startingPage "11963" @default.
- W2138241311 abstract "The latent membrane protein 1 (LMP1) of the Epstein-Barr virus has transforming properties in rodent fibroblasts and is expressed in most of the cancers associated with Epstein-Barr virus (EBV) infection including posttransplant lymphomas, Hodgkin's disease, nasopharyngeal carcinoma, and AIDS-related lymphomas. In this study, three lineages of LMP1 transgenic mice were established with LMP1 expressed under the control of the Ig heavy chain promoter and enhancer. Lymphoma developed in all three lineages, and the incidence of lymphoma increased significantly with age with lymphomas developing in 42% of transgenic mice over 18 months. The expression of LMP1 was detected at high levels in the lymphoma tissues but only at trace levels in normal lymphoid tissues. Gene rearrangement of the Ig heavy chain indicated monoclonality or oligoclonality in all lymphomas, some of the lymphoid hyperplastic spleens, and some histologically normal spleens. These data reveal that LMP1, without the expression of other EBV genes, is oncogenic in vivo and indicate that LMP1 is a major contributing factor to the development of EBV-associated lymphomas." @default.
- W2138241311 created "2016-06-24" @default.
- W2138241311 creator A5001515899 @default.
- W2138241311 creator A5001613927 @default.
- W2138241311 creator A5016034663 @default.
- W2138241311 creator A5022059483 @default.
- W2138241311 creator A5037175509 @default.
- W2138241311 creator A5078993509 @default.
- W2138241311 date "1998-09-29" @default.
- W2138241311 modified "2023-10-09" @default.
- W2138241311 title "Expression of the Epstein–Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice" @default.
- W2138241311 cites W1505818190 @default.
- W2138241311 cites W1507472194 @default.
- W2138241311 cites W1513353467 @default.
- W2138241311 cites W1543144175 @default.
- W2138241311 cites W1556184803 @default.
- W2138241311 cites W1578614833 @default.
- W2138241311 cites W1581524975 @default.
- W2138241311 cites W1604455297 @default.
- W2138241311 cites W1763146100 @default.
- W2138241311 cites W1861086068 @default.
- W2138241311 cites W1921320812 @default.
- W2138241311 cites W1963761369 @default.
- W2138241311 cites W1964134937 @default.
- W2138241311 cites W1968075576 @default.
- W2138241311 cites W1970269101 @default.
- W2138241311 cites W1972992388 @default.
- W2138241311 cites W1976038917 @default.
- W2138241311 cites W1980022529 @default.
- W2138241311 cites W1991494214 @default.
- W2138241311 cites W1995775226 @default.
- W2138241311 cites W2014140505 @default.
- W2138241311 cites W2019107361 @default.
- W2138241311 cites W2021920683 @default.
- W2138241311 cites W2027998343 @default.
- W2138241311 cites W2032514624 @default.
- W2138241311 cites W2047785283 @default.
- W2138241311 cites W2051649088 @default.
- W2138241311 cites W2057267741 @default.
- W2138241311 cites W2060354164 @default.
- W2138241311 cites W2064567786 @default.
- W2138241311 cites W2068606395 @default.
- W2138241311 cites W2071919963 @default.
- W2138241311 cites W2079199354 @default.
- W2138241311 cites W2094799975 @default.
- W2138241311 cites W2101657495 @default.
- W2138241311 cites W2103918307 @default.
- W2138241311 cites W2133074755 @default.
- W2138241311 cites W2149835039 @default.
- W2138241311 cites W2156204386 @default.
- W2138241311 cites W2156675999 @default.
- W2138241311 cites W2168219542 @default.
- W2138241311 cites W2412589223 @default.
- W2138241311 cites W4313333665 @default.
- W2138241311 doi "https://doi.org/10.1073/pnas.95.20.11963" @default.
- W2138241311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/21748" @default.
- W2138241311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9751773" @default.
- W2138241311 hasPublicationYear "1998" @default.
- W2138241311 type Work @default.
- W2138241311 sameAs 2138241311 @default.
- W2138241311 citedByCount "381" @default.
- W2138241311 countsByYear W21382413112012 @default.
- W2138241311 countsByYear W21382413112013 @default.
- W2138241311 countsByYear W21382413112014 @default.
- W2138241311 countsByYear W21382413112015 @default.
- W2138241311 countsByYear W21382413112016 @default.
- W2138241311 countsByYear W21382413112017 @default.
- W2138241311 countsByYear W21382413112018 @default.
- W2138241311 countsByYear W21382413112019 @default.
- W2138241311 countsByYear W21382413112020 @default.
- W2138241311 countsByYear W21382413112021 @default.
- W2138241311 countsByYear W21382413112022 @default.
- W2138241311 countsByYear W21382413112023 @default.
- W2138241311 crossrefType "journal-article" @default.
- W2138241311 hasAuthorship W2138241311A5001515899 @default.
- W2138241311 hasAuthorship W2138241311A5001613927 @default.
- W2138241311 hasAuthorship W2138241311A5016034663 @default.
- W2138241311 hasAuthorship W2138241311A5022059483 @default.
- W2138241311 hasAuthorship W2138241311A5037175509 @default.
- W2138241311 hasAuthorship W2138241311A5078993509 @default.
- W2138241311 hasBestOaLocation W21382413111 @default.
- W2138241311 hasConcept C102230213 @default.
- W2138241311 hasConcept C104317684 @default.
- W2138241311 hasConcept C126322002 @default.
- W2138241311 hasConcept C141035611 @default.
- W2138241311 hasConcept C159047783 @default.
- W2138241311 hasConcept C159654299 @default.
- W2138241311 hasConcept C181152851 @default.
- W2138241311 hasConcept C203014093 @default.
- W2138241311 hasConcept C2522874641 @default.
- W2138241311 hasConcept C2776409557 @default.
- W2138241311 hasConcept C2777257650 @default.
- W2138241311 hasConcept C2778453870 @default.
- W2138241311 hasConcept C2778847070 @default.
- W2138241311 hasConcept C2778997737 @default.
- W2138241311 hasConcept C2779338263 @default.
- W2138241311 hasConcept C2780727368 @default.
- W2138241311 hasConcept C2781375147 @default.