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- W2138264137 abstract "Parenteral administration of N-acetyl-L-glutamine (NAQ) produces substantial urinary losses. To evaluate enteral utility, we examined NAQ hydrolysis by acylase I, a critical first step in biological utilization. NAQ was quantitatively hydrolyzed to glutamine in vitro. Enzyme kinetic parameters were compared for NAQ (Km = 11.4 mM, Vmax = 5.54 nmole glutamine/min/μg enzyme) and an approved food additive, N-acetyl-L-methionine (NAM) (Km = 1.36 mM, Vmax = 7.48 nmole methionine/min/μg enzyme). These data indicated preference for NAM in substrate recognition (Km), but similar relative catalytic ability (Vmax). While NAQ is possibly a suitable enteral glutamine source, utility will depend on intestinal acylase I levels and intestinal residence times not yet determined. Keywords: nutrition, N-acetyl-L-glutamine, glutamine, acylase, bioavailability" @default.
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- W2138264137 date "2001-11-01" @default.
- W2138264137 modified "2023-10-16" @default.
- W2138264137 title "Hydrolysis of N-Acetyl-L-Glutamine by Acylase I" @default.
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- W2138264137 doi "https://doi.org/10.1111/j.1365-2621.2001.tb15226.x" @default.
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