FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138284015> ?p ?o ?g. }

• W2138284015 endingPage "6185" @default.
• W2138284015 startingPage "6175" @default.
• W2138284015 abstract "C1q, the first component of the classical complement pathway, is also a pattern recognition receptor involved in the recognition and clearance of apoptotic cells. C1q deficiency in humans leads to development of lupus-like autoimmune disease, and it has been speculated that impaired clearance of apoptotic cells may contribute to disease development. Since phagocytes initiate specific and appropriate immune responses as a result of initial ligand-receptor interactions, regulation of gene expression by C1q may also contribute to the sculpting of an immune response to the ingested self-Ags. In this study, the role of C1q in apoptotic cell clearance and subsequent modulation of cytokine release by phagocytes was assessed including donor matched human monocytes, monocyte-derived macrophages (HMDMs), and dendritic cells (DCs). First, C1q binding is much greater to late compared with early apoptotic cells. Second, C1q binding to apoptotic cells significantly enhanced the levels of ingestion by monocytes but had no effect on HMDM and DC uptake. Third, in the presence of serum, C1q bound to apoptotic cells, activated the complement pathway, leading to C3b deposition, and enhancement of uptake of apoptotic cells by monocytes, HMDMs, and DCs. Finally, although C1q, either immobilized on a plate or bound to apoptotic cells, modulates the LPS-induced cytokine levels released by human monocytes, HMDMs, and DCs toward a more limited immune response, both the degree and direction of modulation differed significantly depending on the differentiation state of the phagocyte, providing further evidence of the integration of these cell- and environment-specific signals in determining appropriate immune responses." @default.
• W2138284015 created "2016-06-24" @default.
• W2138284015 creator A5034468688 @default.
• W2138284015 creator A5073157706 @default.
• W2138284015 creator A5079112900 @default.
• W2138284015 creator A5086973652 @default.
• W2138284015 date "2009-11-15" @default.
• W2138284015 modified "2023-10-04" @default.
• W2138284015 title "C1q Differentially Modulates Phagocytosis and Cytokine Responses during Ingestion of Apoptotic Cells by Human Monocytes, Macrophages, and Dendritic Cells" @default.
• W2138284015 cites W121687570 @default.
• W2138284015 cites W1488377901 @default.
• W2138284015 cites W1513606958 @default.
• W2138284015 cites W1538637206 @default.
• W2138284015 cites W1552769647 @default.
• W2138284015 cites W1568481877 @default.
• W2138284015 cites W1573103899 @default.
• W2138284015 cites W1589451560 @default.
• W2138284015 cites W1611849651 @default.
• W2138284015 cites W1630503232 @default.
• W2138284015 cites W1758790905 @default.
• W2138284015 cites W1837942605 @default.
• W2138284015 cites W1884465141 @default.
• W2138284015 cites W1893191635 @default.
• W2138284015 cites W1929879919 @default.
• W2138284015 cites W1942720838 @default.
• W2138284015 cites W1961991439 @default.
• W2138284015 cites W1968078518 @default.
• W2138284015 cites W1971505293 @default.
• W2138284015 cites W1977446721 @default.
• W2138284015 cites W1989725197 @default.
• W2138284015 cites W1990366000 @default.
• W2138284015 cites W1992178721 @default.
• W2138284015 cites W1995856339 @default.
• W2138284015 cites W2003870922 @default.
• W2138284015 cites W2011709265 @default.
• W2138284015 cites W2012679621 @default.
• W2138284015 cites W2030175762 @default.
• W2138284015 cites W2031758582 @default.
• W2138284015 cites W2033005687 @default.
• W2138284015 cites W2034815827 @default.
• W2138284015 cites W2037014844 @default.
• W2138284015 cites W2041912408 @default.
• W2138284015 cites W2042188685 @default.
• W2138284015 cites W2042646794 @default.
• W2138284015 cites W2047719515 @default.
• W2138284015 cites W2049727721 @default.
• W2138284015 cites W2053180426 @default.
• W2138284015 cites W2057064377 @default.
• W2138284015 cites W2058894435 @default.
• W2138284015 cites W2067217824 @default.
• W2138284015 cites W2073378914 @default.
• W2138284015 cites W2074721716 @default.
• W2138284015 cites W2075128108 @default.
• W2138284015 cites W2076293933 @default.
• W2138284015 cites W2081179849 @default.
• W2138284015 cites W2090267942 @default.
• W2138284015 cites W2090817877 @default.
• W2138284015 cites W2091493364 @default.
• W2138284015 cites W2095465926 @default.
• W2138284015 cites W2095537212 @default.
• W2138284015 cites W2113554363 @default.
• W2138284015 cites W2119941463 @default.
• W2138284015 cites W2124878893 @default.
• W2138284015 cites W2126261381 @default.
• W2138284015 cites W2126864422 @default.
• W2138284015 cites W2127321441 @default.
• W2138284015 cites W2140647514 @default.
• W2138284015 cites W2158006372 @default.
• W2138284015 cites W2158770157 @default.
• W2138284015 cites W2273521055 @default.
• W2138284015 cites W315197452 @default.
• W2138284015 cites W4313333737 @default.
• W2138284015 cites W98597308 @default.
• W2138284015 doi "https://doi.org/10.4049/jimmunol.0902232" @default.
• W2138284015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2843563" @default.
• W2138284015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19864605" @default.
• W2138284015 hasPublicationYear "2009" @default.
• W2138284015 type Work @default.
• W2138284015 sameAs 2138284015 @default.
• W2138284015 citedByCount "134" @default.
• W2138284015 countsByYear W21382840152012 @default.
• W2138284015 countsByYear W21382840152013 @default.
• W2138284015 countsByYear W21382840152014 @default.
• W2138284015 countsByYear W21382840152015 @default.
• W2138284015 countsByYear W21382840152016 @default.
• W2138284015 countsByYear W21382840152017 @default.
• W2138284015 countsByYear W21382840152018 @default.
• W2138284015 countsByYear W21382840152019 @default.
• W2138284015 countsByYear W21382840152020 @default.
• W2138284015 countsByYear W21382840152021 @default.
• W2138284015 countsByYear W21382840152022 @default.
• W2138284015 countsByYear W21382840152023 @default.
• W2138284015 crossrefType "journal-article" @default.
• W2138284015 hasAuthorship W2138284015A5034468688 @default.
• W2138284015 hasAuthorship W2138284015A5073157706 @default.
• W2138284015 hasAuthorship W2138284015A5079112900 @default.
• W2138284015 hasAuthorship W2138284015A5086973652 @default.
• W2138284015 hasBestOaLocation W21382840151 @default.

• next