FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138304179> ?p ?o ?g. }

• W2138304179 endingPage "46" @default.
• W2138304179 startingPage "46" @default.
• W2138304179 abstract "Immune system dysfunction during aging is well documented fact. Changes in the adaptive immune system are the most marked, especially in the T-cell compartment. In multiple preliminary studies it has been shown that parabiosis between 2 animals of different age can induce age-related changes in adaptive immune response and T-cell subpopulation composition of younger animal. In present study we evaluated the age-related changes in functions of rapidly renewing (macrophages) and slowly renewing cells (CD11c+ DCs) cells in spleens of young and old parabionts. We observed impaired capacity of splenic adherent cells from younger heterochronic parabionts to co-stimulate proliferation of autologous T-cells in vitro up to the level of old animals. Also we observed negative effect of this splenic cell population on intracellular signaling mechanisms that regulate PHA-activated proliferation of T-cells from young animals: statistically significant decrease of NFκB p65 expression and increased expression of IκBα during early activation events. This fact suggests that splenic macrophages may be involved in the induction of age-related changes of the immune system and they can be prospective target for further investigation." @default.
• W2138304179 created "2016-06-24" @default.
• W2138304179 creator A5001888691 @default.
• W2138304179 date "2015-01-01" @default.
• W2138304179 modified "2023-09-30" @default.
• W2138304179 title "Splenic Niche Cells from Young Heterochronic Parabionts Have Decreased Capability to Amplify T-cell Proliferation in Vitro" @default.
• W2138304179 cites W1602460865 @default.
• W2138304179 cites W1700179117 @default.
• W2138304179 cites W1960367851 @default.
• W2138304179 cites W1969905245 @default.
• W2138304179 cites W1986331996 @default.
• W2138304179 cites W2003870922 @default.
• W2138304179 cites W2004919841 @default.
• W2138304179 cites W2031619581 @default.
• W2138304179 cites W2032041063 @default.
• W2138304179 cites W2035279182 @default.
• W2138304179 cites W2040163024 @default.
• W2138304179 cites W2054472394 @default.
• W2138304179 cites W2058030472 @default.
• W2138304179 cites W2061014336 @default.
• W2138304179 cites W2062515891 @default.
• W2138304179 cites W2062858069 @default.
• W2138304179 cites W2076219964 @default.
• W2138304179 cites W2077962760 @default.
• W2138304179 cites W2085099489 @default.
• W2138304179 cites W2089372310 @default.
• W2138304179 cites W2092427093 @default.
• W2138304179 cites W2096890213 @default.
• W2138304179 cites W2098473219 @default.
• W2138304179 cites W2100412095 @default.
• W2138304179 cites W2100820895 @default.
• W2138304179 cites W2109771791 @default.
• W2138304179 cites W2114918609 @default.
• W2138304179 cites W2121795093 @default.
• W2138304179 cites W2122144979 @default.
• W2138304179 cites W2127424425 @default.
• W2138304179 cites W2137105060 @default.
• W2138304179 cites W2145034018 @default.
• W2138304179 cites W2152126520 @default.
• W2138304179 cites W2162135540 @default.
• W2138304179 cites W2166183563 @default.
• W2138304179 cites W2167350292 @default.
• W2138304179 cites W2170107603 @default.
• W2138304179 cites W2396777667 @default.
• W2138304179 doi "https://doi.org/10.11648/j.ajbio.20150302.14" @default.
• W2138304179 hasPublicationYear "2015" @default.
• W2138304179 type Work @default.
• W2138304179 sameAs 2138304179 @default.
• W2138304179 citedByCount "6" @default.
• W2138304179 countsByYear W21383041792016 @default.
• W2138304179 countsByYear W21383041792017 @default.
• W2138304179 countsByYear W21383041792023 @default.
• W2138304179 crossrefType "journal-article" @default.
• W2138304179 hasAuthorship W2138304179A5001888691 @default.
• W2138304179 hasBestOaLocation W21383041791 @default.
• W2138304179 hasConcept C104317684 @default.
• W2138304179 hasConcept C127716648 @default.
• W2138304179 hasConcept C193419808 @default.
• W2138304179 hasConcept C202751555 @default.
• W2138304179 hasConcept C203014093 @default.
• W2138304179 hasConcept C2776090121 @default.
• W2138304179 hasConcept C2777380497 @default.
• W2138304179 hasConcept C2779919695 @default.
• W2138304179 hasConcept C2780931953 @default.
• W2138304179 hasConcept C2908647359 @default.
• W2138304179 hasConcept C54355233 @default.
• W2138304179 hasConcept C71924100 @default.
• W2138304179 hasConcept C86803240 @default.
• W2138304179 hasConcept C8891405 @default.
• W2138304179 hasConcept C95444343 @default.
• W2138304179 hasConcept C99454951 @default.
• W2138304179 hasConceptScore W2138304179C104317684 @default.
• W2138304179 hasConceptScore W2138304179C127716648 @default.
• W2138304179 hasConceptScore W2138304179C193419808 @default.
• W2138304179 hasConceptScore W2138304179C202751555 @default.
• W2138304179 hasConceptScore W2138304179C203014093 @default.
• W2138304179 hasConceptScore W2138304179C2776090121 @default.
• W2138304179 hasConceptScore W2138304179C2777380497 @default.
• W2138304179 hasConceptScore W2138304179C2779919695 @default.
• W2138304179 hasConceptScore W2138304179C2780931953 @default.
• W2138304179 hasConceptScore W2138304179C2908647359 @default.
• W2138304179 hasConceptScore W2138304179C54355233 @default.
• W2138304179 hasConceptScore W2138304179C71924100 @default.
• W2138304179 hasConceptScore W2138304179C86803240 @default.
• W2138304179 hasConceptScore W2138304179C8891405 @default.
• W2138304179 hasConceptScore W2138304179C95444343 @default.
• W2138304179 hasConceptScore W2138304179C99454951 @default.
• W2138304179 hasIssue "2" @default.
• W2138304179 hasLocation W21383041791 @default.
• W2138304179 hasOpenAccess W2138304179 @default.
• W2138304179 hasPrimaryLocation W21383041791 @default.
• W2138304179 hasRelatedWork W1524647360 @default.
• W2138304179 hasRelatedWork W2031253481 @default.
• W2138304179 hasRelatedWork W2081358646 @default.
• W2138304179 hasRelatedWork W2141330728 @default.
• W2138304179 hasRelatedWork W2164219360 @default.
• W2138304179 hasRelatedWork W3031921507 @default.
• W2138304179 hasRelatedWork W4206425682 @default.

• next