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• W2138314562 abstract "The 24-hr patterns of plasma thyrotropin have been observed in 12 endogenous depressed patients in both depressed and recovered states and in 13 normal subjects. A clear circadian rhythm was detected in controls with high values at night. In depression, the circadian rhythm was altered with amplitude reduction and blunted nocturnal secretion, abnormalities particularly relevant in bipolar patients. This flattened profile could be linked to the blunted response of TSH to TRH administration reported in depressed patients. Normal nyctohemeral patterns have been restored after recovery. These chronobiological abnormalities as well as their normalization under antidepressant drugs seem to be similar to those reported for various parameters (e.g. temperature, Cortisol, etc) in depression which could support the chronobiological hypothesis for affective disorders." @default.
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• W2138314562 date "1986-01-01" @default.
• W2138314562 modified "2023-10-17" @default.
• W2138314562 title "The Circadian Rhythm of Plasma Thyrotropin in Depression and Recovery" @default.
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• W2138314562 doi "https://doi.org/10.3109/07420528609066367" @default.
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