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• W2138343007 abstract "Ewing sarcoma, a rare malignancy of childhood and adolescence, has become a model of advances in diagnosis, treatment, and outcome through long-standing research efforts in multinational clinical trials. With modern multimodal regimens consisting of local surgery and/or radiotherapy plus intensive systemic chemotherapy, survival can be achieved for ∼70% of patients with localized disease. However, in the last decade, improvement in survival curves has slowed down. Also, a relapse rate of ∼30% remains unacceptable, since salvage strategies for Ewing sarcoma recurrence are discouraging and prognosis is unfavorable in most cases. Metastatic disease at diagnosis poses a similar challenge, since even if remission is achieved, relapse frequently occurs despite the most intensive treatment. Urgently needed, novel biology-driven treatment options are now beginning to emerge on the horizon, but have not yet reached the standard of care. An overview of the current clinical state-of-the-art is provided in this article." @default.
• W2138343007 created "2016-06-24" @default.
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• W2138343007 date "2012-01-27" @default.
• W2138343007 modified "2023-09-30" @default.
• W2138343007 title "Ewing Sarcoma: Clinical State-of-the-Art" @default.
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• W2138343007 doi "https://doi.org/10.3109/08880018.2011.622034" @default.
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