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• W2138361567 abstract "Several methicillin-resistant Staphylococcus aureus (MRSA) lineages that carry a novel mecA homologue (mecC) have recently been described in livestock and humans. In Denmark, two independent human cases of mecC-MRSA infection have been linked to a livestock reservoir. We investigated the molecular epidemiology of the associated MRSA isolates using whole genome sequencing (WGS). Single nucleotide polymorphisms (SNP) were defined and compared to a reference genome to place the isolates into a phylogenetic context. Phylogenetic analysis revealed two distinct farm-specific clusters comprising isolates from the human case and their own livestock, whereas human and animal isolates from the same farm only differed by a small number of SNPs, which supports the likelihood of zoonotic transmission. Further analyses identified a number of genes and mutations that may be associated with host interaction and virulence. This study demonstrates that mecC-MRSA ST130 isolates are capable of transmission between animals and humans, and underscores the potential of WGS in epidemiological investigations and source tracking of bacterial infections." @default.
• W2138361567 created "2016-06-24" @default.
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• W2138361567 date "2013-03-25" @default.
• W2138361567 modified "2023-10-09" @default.
• W2138361567 title "Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel <i>mecA</i> homologue <i>mecC</i>" @default.
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• W2138361567 doi "https://doi.org/10.1002/emmm.201202413" @default.
• W2138361567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3628104" @default.
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• W2138361567 hasPublicationYear "2013" @default.
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