Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138403791> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2138403791 abstract "N4-behenoyl-1-beta-D-arabinofuranosylcytosine (BH-AC) is one of the ara-C derivatives resistant to deamination. Administration of BH-AC in an intermediate (500 mg/m2) or a high dose (1000 mg/m2) resulted in maximum BH-AC plasma levels that were 10 to 20 times as high as those obtained at the conventional BH-AC dose and prolonged maintenance of comparatively high levels. High concentrations of ara-C in the plasma were observed just after BH-AC administration and at 24 hours were proportionally far higher than the ratio between the BH-AC doses administered in this study and those usually administered. To prevent the occurrence of shock, which has reportedly occurred in other studies, because of the presence of HCO-60, hydrocortisone was administered together with BH-AC in this study. In the two patients studied, no shock was observed and the only side effects were transient nausea and vomiting. The results suggest that administration of intermediate and high doses of BH-AC, accompanied by HDC, will prove a safe, effective means of enhancing the efficacy of leukemia therapy." @default.
- W2138403791 created "2016-06-24" @default.
- W2138403791 creator A5087545401 @default.
- W2138403791 date "1988-04-01" @default.
- W2138403791 modified "2023-09-27" @default.
- W2138403791 title "Clinical Use of Intermediate to High Dose of N4-Behenoyl-1-β-D-arabinofuranosylcytosine in Children with Acute Leukemia" @default.
- W2138403791 cites W1485550508 @default.
- W2138403791 cites W153673717 @default.
- W2138403791 cites W1965377737 @default.
- W2138403791 cites W1994229131 @default.
- W2138403791 cites W2007557971 @default.
- W2138403791 cites W2075761692 @default.
- W2138403791 cites W2109372368 @default.
- W2138403791 cites W2161820516 @default.
- W2138403791 cites W2417458035 @default.
- W2138403791 cites W2462779651 @default.
- W2138403791 cites W4239535907 @default.
- W2138403791 doi "https://doi.org/10.1002/j.1552-4604.1988.tb03158.x" @default.
- W2138403791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3164731" @default.
- W2138403791 hasPublicationYear "1988" @default.
- W2138403791 type Work @default.
- W2138403791 sameAs 2138403791 @default.
- W2138403791 citedByCount "1" @default.
- W2138403791 crossrefType "journal-article" @default.
- W2138403791 hasAuthorship W2138403791A5087545401 @default.
- W2138403791 hasConcept C126322002 @default.
- W2138403791 hasConcept C145782189 @default.
- W2138403791 hasConcept C181199279 @default.
- W2138403791 hasConcept C185592680 @default.
- W2138403791 hasConcept C2776863199 @default.
- W2138403791 hasConcept C2778041864 @default.
- W2138403791 hasConcept C2778461978 @default.
- W2138403791 hasConcept C2780580376 @default.
- W2138403791 hasConcept C2780852908 @default.
- W2138403791 hasConcept C2781300812 @default.
- W2138403791 hasConcept C55493867 @default.
- W2138403791 hasConcept C71924100 @default.
- W2138403791 hasConcept C90924648 @default.
- W2138403791 hasConcept C98274493 @default.
- W2138403791 hasConceptScore W2138403791C126322002 @default.
- W2138403791 hasConceptScore W2138403791C145782189 @default.
- W2138403791 hasConceptScore W2138403791C181199279 @default.
- W2138403791 hasConceptScore W2138403791C185592680 @default.
- W2138403791 hasConceptScore W2138403791C2776863199 @default.
- W2138403791 hasConceptScore W2138403791C2778041864 @default.
- W2138403791 hasConceptScore W2138403791C2778461978 @default.
- W2138403791 hasConceptScore W2138403791C2780580376 @default.
- W2138403791 hasConceptScore W2138403791C2780852908 @default.
- W2138403791 hasConceptScore W2138403791C2781300812 @default.
- W2138403791 hasConceptScore W2138403791C55493867 @default.
- W2138403791 hasConceptScore W2138403791C71924100 @default.
- W2138403791 hasConceptScore W2138403791C90924648 @default.
- W2138403791 hasConceptScore W2138403791C98274493 @default.
- W2138403791 hasLocation W21384037911 @default.
- W2138403791 hasLocation W21384037912 @default.
- W2138403791 hasOpenAccess W2138403791 @default.
- W2138403791 hasPrimaryLocation W21384037911 @default.
- W2138403791 hasRelatedWork W1978668887 @default.
- W2138403791 hasRelatedWork W2109372368 @default.
- W2138403791 hasRelatedWork W2370935967 @default.
- W2138403791 hasRelatedWork W2389605378 @default.
- W2138403791 hasRelatedWork W2399260822 @default.
- W2138403791 hasRelatedWork W2406249232 @default.
- W2138403791 hasRelatedWork W2435790466 @default.
- W2138403791 hasRelatedWork W2899084033 @default.
- W2138403791 hasRelatedWork W4239800856 @default.
- W2138403791 hasRelatedWork W54826626 @default.
- W2138403791 isParatext "false" @default.
- W2138403791 isRetracted "false" @default.
- W2138403791 magId "2138403791" @default.
- W2138403791 workType "article" @default.