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• W2138413019 endingPage "1254" @default.
• W2138413019 startingPage "1247" @default.
• W2138413019 abstract "The study aim was to investigate the association of cardiovascular risk factors with insulin resistance and impaired insulin secretion in an 8-year prospective population study in nondiabetic subjects. Cardiovascular risk factors of 271 subjects aged 16 to 61 years were measured at baseline, and insulin sensitivity and acute-phase insulin secretion were assessed by an intravenous glucose tolerance test (IVGTT) and Bergman's minimal model 8 years later. In logistic regression analysis, baseline high-density lipoprotein (HDL) and very-low-density lipoprotein (VLDL) cholesterol (P < .001 and P = .006, respectively), total, low-density lipoprotein (LDL), and VLDL triglycerides (P = .004, P = .048, and P = .002, respectively), apolipoprotein A1 (P = .010), and uric acid (P < .001) were associated with insulin resistance after adjustment for age and the body mass index (BMI). Systolic blood pressure (P = .042) and VLDL cholesterol (P = .018) were associated with impaired insulin secretion after adjustment for age and the BMI. This 8-year longitudinal study demonstrates that dyslipidemia, high blood pressure, and uric acid are associated with insulin resistance, whereas high systolic blood pressure and VLDL cholesterol are associated with impaired first-phase insulin secretion." @default.
• W2138413019 created "2016-06-24" @default.
• W2138413019 creator A5013519955 @default.
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• W2138413019 date "2000-10-01" @default.
• W2138413019 modified "2023-10-04" @default.
• W2138413019 title "Long-term association of cardiovascular risk factors with impaired insulin secretion and insulin resistance" @default.
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• W2138413019 doi "https://doi.org/10.1053/meta.2000.9514" @default.
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