FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138416076> ?p ?o ?g. }

• W2138416076 endingPage "2730" @default.
• W2138416076 startingPage "2723" @default.
• W2138416076 abstract "ABSTRACT Tryptophan depletion resulting from indoleamine 2,3-dioxygenase (IDO) activity within the kynurenine pathway is one of the most prominent gamma interferon (IFN-γ)-inducible antimicrobial effector mechanisms in human cells. On the other hand, nitric oxide (NO) produced by the inducible isoform of NO synthase (iNOS) serves a more immunoregulatory role in human cells and thereby interacts with tryptophan depletion in a number of ways. We investigated the effects of NO on IDO gene transcription, protein synthesis, and enzyme activity as well as on IDO-mediated bacteriostasis in the human epithelial cell line RT4. IFN-γ-stimulated RT4 cells were able to inhibit the growth of Staphylococcus aureus in an IDO-mediated fashion, and this bacteriostatic effect was abolished by endogenously produced NO. These findings were supported by experiments which showed that IDO activity in extracts of IFN-γ-stimulated cells is inhibited by the chemical NO donors diethylenetriamine diazeniumdiolate, S-nitroso- l -cysteine, and S-nitroso- N -acetyl- d , l -penicillamine. Furthermore, we found that both endogenous and exogenous NO strongly reduced the level of IDO protein content in RT4 cells. This effect was not due to a decrease in IDO gene transcription or mRNA stability. By using inhibitors of proteasomal proteolytic activity, we showed that NO production led to an accelerated degradation of IDO protein in the proteasome. This is the first report, to our knowledge, that demonstrates that the IDO is degraded by the proteasome and that NO has an effect on IDO protein stability." @default.
• W2138416076 created "2016-06-24" @default.
• W2138416076 creator A5022233013 @default.
• W2138416076 creator A5027786740 @default.
• W2138416076 creator A5048266169 @default.
• W2138416076 creator A5050334407 @default.
• W2138416076 creator A5067902098 @default.
• W2138416076 date "2004-05-01" @default.
• W2138416076 modified "2023-10-12" @default.
• W2138416076 title "Nitric Oxide-Mediated Regulation of Gamma Interferon-Induced Bacteriostasis: Inhibition and Degradation of Human Indoleamine 2,3-Dioxygenase" @default.
• W2138416076 cites W1493931678 @default.
• W2138416076 cites W1498611516 @default.
• W2138416076 cites W1518552940 @default.
• W2138416076 cites W1601858970 @default.
• W2138416076 cites W1622259963 @default.
• W2138416076 cites W1892959235 @default.
• W2138416076 cites W1974401900 @default.
• W2138416076 cites W1979388174 @default.
• W2138416076 cites W1982233191 @default.
• W2138416076 cites W2001848039 @default.
• W2138416076 cites W2004212058 @default.
• W2138416076 cites W2007749861 @default.
• W2138416076 cites W2008623993 @default.
• W2138416076 cites W2015260577 @default.
• W2138416076 cites W2020736600 @default.
• W2138416076 cites W2022430924 @default.
• W2138416076 cites W2038163944 @default.
• W2138416076 cites W2043774977 @default.
• W2138416076 cites W2049299765 @default.
• W2138416076 cites W2068192272 @default.
• W2138416076 cites W2071159330 @default.
• W2138416076 cites W2071293996 @default.
• W2138416076 cites W2072321053 @default.
• W2138416076 cites W2075224966 @default.
• W2138416076 cites W2092524794 @default.
• W2138416076 cites W2120240287 @default.
• W2138416076 cites W2126341873 @default.
• W2138416076 cites W2127475487 @default.
• W2138416076 cites W2138558289 @default.
• W2138416076 cites W2139518224 @default.
• W2138416076 cites W2146914242 @default.
• W2138416076 cites W2158544309 @default.
• W2138416076 cites W2162182601 @default.
• W2138416076 cites W2163510491 @default.
• W2138416076 cites W2167897482 @default.
• W2138416076 cites W2397320519 @default.
• W2138416076 cites W36502835 @default.
• W2138416076 doi "https://doi.org/10.1128/iai.72.5.2723-2730.2004" @default.
• W2138416076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/387869" @default.
• W2138416076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15102781" @default.
• W2138416076 hasPublicationYear "2004" @default.
• W2138416076 type Work @default.
• W2138416076 sameAs 2138416076 @default.
• W2138416076 citedByCount "99" @default.
• W2138416076 countsByYear W21384160762012 @default.
• W2138416076 countsByYear W21384160762013 @default.
• W2138416076 countsByYear W21384160762014 @default.
• W2138416076 countsByYear W21384160762015 @default.
• W2138416076 countsByYear W21384160762016 @default.
• W2138416076 countsByYear W21384160762017 @default.
• W2138416076 countsByYear W21384160762018 @default.
• W2138416076 countsByYear W21384160762019 @default.
• W2138416076 countsByYear W21384160762020 @default.
• W2138416076 countsByYear W21384160762021 @default.
• W2138416076 countsByYear W21384160762022 @default.
• W2138416076 countsByYear W21384160762023 @default.
• W2138416076 crossrefType "journal-article" @default.
• W2138416076 hasAuthorship W2138416076A5022233013 @default.
• W2138416076 hasAuthorship W2138416076A5027786740 @default.
• W2138416076 hasAuthorship W2138416076A5048266169 @default.
• W2138416076 hasAuthorship W2138416076A5050334407 @default.
• W2138416076 hasAuthorship W2138416076A5067902098 @default.
• W2138416076 hasBestOaLocation W21384160761 @default.
• W2138416076 hasConcept C134018914 @default.
• W2138416076 hasConcept C138885662 @default.
• W2138416076 hasConcept C153911025 @default.
• W2138416076 hasConcept C179926584 @default.
• W2138416076 hasConcept C203014093 @default.
• W2138416076 hasConcept C27740335 @default.
• W2138416076 hasConcept C2776178377 @default.
• W2138416076 hasConcept C2776706248 @default.
• W2138416076 hasConcept C2777503454 @default.
• W2138416076 hasConcept C2778690821 @default.
• W2138416076 hasConcept C2780841837 @default.
• W2138416076 hasConcept C41895202 @default.
• W2138416076 hasConcept C515207424 @default.
• W2138416076 hasConcept C51785407 @default.
• W2138416076 hasConcept C519581460 @default.
• W2138416076 hasConcept C55493867 @default.
• W2138416076 hasConcept C83478079 @default.
• W2138416076 hasConcept C86803240 @default.
• W2138416076 hasConcept C95444343 @default.
• W2138416076 hasConceptScore W2138416076C134018914 @default.
• W2138416076 hasConceptScore W2138416076C138885662 @default.
• W2138416076 hasConceptScore W2138416076C153911025 @default.
• W2138416076 hasConceptScore W2138416076C179926584 @default.
• W2138416076 hasConceptScore W2138416076C203014093 @default.
• W2138416076 hasConceptScore W2138416076C27740335 @default.

• next