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• W2138443691 abstract "ntestinal parasites remain a major health problem in many developing countries. There are approximately 60 species of whipworms that infect mammals. Trichuris trichiura (T. trichiura), whipworm gets their name from the characteristic shape of the adults.1 The World Health Organization estimated that there were 500 million cases of T. trichiura infection worldwide.2 Most infections are asymptomatic. However, as the worms live a long time and a person can be reinfected constantly and heavy worm burdens can develop. Heavy infections cause abdominal discomfort, anemia, bloody diarrhea, rectum prolapse and appendicitis. Diagnosis of trichuriasis is made by detecting the characteristics of eggs in the fecal sample. Trichuris trichiura has been associated with dysentery.3 Lipid peroxidation is a well-established mechanism of cellular injury in human, and is used as an indicator of oxidative stress in cells and tissues. Lipid peroxides, derived from polyunsaturated fatty acids, are unstable and decompose to form a complex series of compounds. These include reactive carbonyl compounds, which is the most abundant malondialdehyde (MDA). Therefore, measurement of malondialdehyde is widely used as an indicator of lipid peroxidation. Increased levels of lipid peroxidation products have been associated with a variety of chronic diseases in both humans and model systems.4 The aim of this study was to test the hypothesis of decreased activity of defense system protecting tissues from free radical damage in patients infected with T. trichiura by measuring the level of MDA (an end-product of lipid peroxidation), in serum samples. We assayed MDA activities of 144 subjects aged between 12-48 years (75 males and 69 females). None of them were smokers, had any known pathologies and taking steroids or medications such as iron for anemia at the time of sampling. Serum samples for control group were obtained from healthy people who have come to the different departments of Erciyes University, Medical Faculty for regular check-up and students or employees of the University. Wet mount preparations in 0.9% NaCl, diluted Lugol’s iodine and flotation technique I in saturated saline solution were used for detection of intestinal parasites. Serum MDA levels were measured by the double heating method.5 The principle of the method was based on the spectrophotometric measurement of the color occurred during the reaction to thiobarbituric acid with MDA. Concentration of thiobarbituric acid reactive substances (TBARS) was calculated by the absorbance coefficient of MDA-thiobarbituric acid complex and expressed in nmol/ml. Statistical analysis was performed with Statistical Package for Social Sciences Version 11 for Windows. The difference between MDA levels of patients and control group was statistically significant both for females (p 0.05) both in females and males. In addition, no significant correlation could be found between MDA levels of both females and males for patients and control group (p>0.05). Present study was aimed to evaluate and characterize the relationship between intestinal parasite infection of T. trichiura, which can cause serious pathology and oxidative stress mechanism as a mediator of tissue damage concurrent with T. trichiura infection. This is the first study to characterize the relationship between T. trichiura infection and MDA (lipid peroxidation), which is a well-established mechanism of cellular injury in human, and is used as an indicator of oxidative stress in cells and tissues. Trichuris trichiura is one of the most common intestinal parasites of man. The majority of infections are symptomless. The anterior ends of the worms burrow in the mucosa where the worms consume blood cells, although blood loss by this mechanism is negligible. Secondary bacterial infections, possibly coupled with allergic responses, results in colitis, proctitis, and in extreme cases, prolapse of the rectum." @default.
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• W2138443691 date "2004-12-01" @default.
• W2138443691 modified "2023-10-16" @default.
• W2138443691 title "Serum malondialdehyde level in patients infected with Trichuris trichiura." @default.
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