FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138455735> ?p ?o ?g. }

• W2138455735 endingPage "2378" @default.
• W2138455735 startingPage "2368" @default.
• W2138455735 abstract "Abstract Purpose: To better understand the molecular mechanisms that underlay the development and progression of nonseminomatous germ cell tumor of testis (NSGCTT) as well as malignant transformation of teratoma and primitive neuroectodermal tumor (PNET). Experimental Design: We studied the gene expression profiles of 17 retroperitoneal NSGCTTs (10 yolk sac tumors, 3 embryonal carcinomas, 4 teratomas) and 2 PNETs obtained from patients with two clinical outcomes. Tissue samples were obtained from the Indiana University. One group of NSGCTT and PNET patients developed metastases within 2 years (early-relapse) of initial successful treatment, and the other group developed metastases after 2 years (late-relapse). Gene expression in these groups of patients was quantified using cDNA microarrays and real-time relative quantitative PCR. Results: We demonstrate that the gene expression profiles of these tumors correlate with histological type. In addition, we identify type-specific genes that may serve as novel diagnostic markers. We also identify a gene set that can distinguish between early-relapse and late-relapse yolk sac tumors. The expression differences of these genes may underlie the differences in clinical outcome and drug response of these tumors. Conclusion: This is the first study that used gene expression profiling to examine the molecular characteristics of the NSGCTTs and drug response in early- and late-relapse tumors. These results suggest that two molecularly distinct forms of NSGCTTs exist and that the integration of expression profile data with clinical parameters could enhance the diagnosis and prognosis of NSGCTTs. More importantly, the identified genes provide insight into the molecular mechanisms of aggressive NSGCTTs and suggest intervention strategies." @default.
• W2138455735 created "2016-06-24" @default.
• W2138455735 creator A5012831120 @default.
• W2138455735 creator A5019693863 @default.
• W2138455735 creator A5019939988 @default.
• W2138455735 creator A5029761458 @default.
• W2138455735 creator A5035423584 @default.
• W2138455735 creator A5035913183 @default.
• W2138455735 creator A5048660181 @default.
• W2138455735 creator A5071434634 @default.
• W2138455735 creator A5076351536 @default.
• W2138455735 date "2004-04-01" @default.
• W2138455735 modified "2023-10-16" @default.
• W2138455735 title "Gene Expression Profiling of Early- and Late-Relapse Nonseminomatous Germ Cell Tumor and Primitive Neuroectodermal Tumor of the Testis" @default.
• W2138455735 cites W107630332 @default.
• W2138455735 cites W1509637701 @default.
• W2138455735 cites W1549647993 @default.
• W2138455735 cites W172192228 @default.
• W2138455735 cites W1900110139 @default.
• W2138455735 cites W1939466340 @default.
• W2138455735 cites W1966532246 @default.
• W2138455735 cites W1969761972 @default.
• W2138455735 cites W1969857709 @default.
• W2138455735 cites W1972462861 @default.
• W2138455735 cites W1975292683 @default.
• W2138455735 cites W1989897071 @default.
• W2138455735 cites W2003998005 @default.
• W2138455735 cites W2014133194 @default.
• W2138455735 cites W2017977879 @default.
• W2138455735 cites W2024081693 @default.
• W2138455735 cites W2045272862 @default.
• W2138455735 cites W2049388096 @default.
• W2138455735 cites W2056790195 @default.
• W2138455735 cites W2068696123 @default.
• W2138455735 cites W2069723359 @default.
• W2138455735 cites W2082465079 @default.
• W2138455735 cites W2097232179 @default.
• W2138455735 cites W2097413644 @default.
• W2138455735 cites W2099388441 @default.
• W2138455735 cites W2100668965 @default.
• W2138455735 cites W2102664258 @default.
• W2138455735 cites W2110406679 @default.
• W2138455735 cites W2112118427 @default.
• W2138455735 cites W2131994307 @default.
• W2138455735 cites W2138178697 @default.
• W2138455735 cites W2143629309 @default.
• W2138455735 cites W2147246240 @default.
• W2138455735 cites W2149668250 @default.
• W2138455735 cites W2150926065 @default.
• W2138455735 cites W2162639940 @default.
• W2138455735 cites W2171780788 @default.
• W2138455735 cites W2322558359 @default.
• W2138455735 cites W2333755772 @default.
• W2138455735 cites W2409853479 @default.
• W2138455735 doi "https://doi.org/10.1158/1078-0432.ccr-03-0341" @default.
• W2138455735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15073113" @default.
• W2138455735 hasPublicationYear "2004" @default.
• W2138455735 type Work @default.
• W2138455735 sameAs 2138455735 @default.
• W2138455735 citedByCount "51" @default.
• W2138455735 countsByYear W21384557352012 @default.
• W2138455735 countsByYear W21384557352013 @default.
• W2138455735 countsByYear W21384557352014 @default.
• W2138455735 countsByYear W21384557352016 @default.
• W2138455735 countsByYear W21384557352017 @default.
• W2138455735 countsByYear W21384557352018 @default.
• W2138455735 countsByYear W21384557352020 @default.
• W2138455735 countsByYear W21384557352021 @default.
• W2138455735 crossrefType "journal-article" @default.
• W2138455735 hasAuthorship W2138455735A5012831120 @default.
• W2138455735 hasAuthorship W2138455735A5019693863 @default.
• W2138455735 hasAuthorship W2138455735A5019939988 @default.
• W2138455735 hasAuthorship W2138455735A5029761458 @default.
• W2138455735 hasAuthorship W2138455735A5035423584 @default.
• W2138455735 hasAuthorship W2138455735A5035913183 @default.
• W2138455735 hasAuthorship W2138455735A5048660181 @default.
• W2138455735 hasAuthorship W2138455735A5071434634 @default.
• W2138455735 hasAuthorship W2138455735A5076351536 @default.
• W2138455735 hasBestOaLocation W21384557351 @default.
• W2138455735 hasConcept C104317684 @default.
• W2138455735 hasConcept C142724271 @default.
• W2138455735 hasConcept C150194340 @default.
• W2138455735 hasConcept C18431079 @default.
• W2138455735 hasConcept C186836561 @default.
• W2138455735 hasConcept C196843134 @default.
• W2138455735 hasConcept C203014093 @default.
• W2138455735 hasConcept C204232928 @default.
• W2138455735 hasConcept C2776057878 @default.
• W2138455735 hasConcept C2776694085 @default.
• W2138455735 hasConcept C2776891213 @default.
• W2138455735 hasConcept C2776938808 @default.
• W2138455735 hasConcept C2777043721 @default.
• W2138455735 hasConcept C2779122487 @default.
• W2138455735 hasConcept C502942594 @default.
• W2138455735 hasConcept C54355233 @default.
• W2138455735 hasConcept C71924100 @default.
• W2138455735 hasConcept C86803240 @default.
• W2138455735 hasConcept C95371953 @default.

• next