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• W2138461207 startingPage "325" @default.
• W2138461207 abstract "Lysophosphatidylcholine (LPC) is a major atherogenic lipid which stimulates the recruitment of monocytes to atherosclerotic lesions. The physiological mechanisms underlying LPC-induced monocyte migration are poorly understood. Here we demonstrate that LPC activates non-selective cation channels, which are significantly involved in LPC-induced chemotaxis of monocytes. External LPC elicited the activation of non-selective cation currents in THP-1 monocytes, which occurred in a G protein and phospholipase C-independent manner. LPC-activated currents were almost completely inhibited by Gd(3+), La(3+), and TRAM-34. Furthermore, currents were partially reduced by either 2-aminoethoxydiphenyl borate (2-APB) or ruthenium red, while combined application of 2-APB and ruthenium red abolished LPC-activated currents. The 2-APB-sensitive current component was potentiated by flufenamic acid and Ca(2+)-free extracellular solution, while the ruthenium red-sensitive current component was abolished by capsazepine. This pharmacological profile suggests that LPC simultaneously activates TRPC6 and TRPV1 channels in monocytes. Furthermore, in the presence of Gd(3+), La(3+), TRAM-34, 2-APB, ruthenium red or capsazepine, LPC-induced chemotaxis of monocytes was substantially inhibited, indicating that activation of both channel types is required for optimal migration of LPC-stimulated monocytes. Thus, ion channel inhibition may represent a powerful strategy to attenuate the progression of atherosclerosis by reducing monocyte infiltration." @default.
• W2138461207 created "2016-06-24" @default.
• W2138461207 creator A5036174284 @default.
• W2138461207 creator A5071963895 @default.
• W2138461207 date "2009-06-26" @default.
• W2138461207 modified "2023-10-01" @default.
• W2138461207 title "Non‐selective cation channel activity is required for lysophosphatidylcholine‐induced monocyte migration" @default.
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• W2138461207 doi "https://doi.org/10.1002/jcp.21857" @default.
• W2138461207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19562685" @default.
• W2138461207 hasPublicationYear "2009" @default.
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