FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138509148> ?p ?o ?g. }

• W2138509148 endingPage "33" @default.
• W2138509148 startingPage "25" @default.
• W2138509148 abstract "Antihypertensive angiotensin II type 1 receptor blockers (ARBs) have neuroprotective effects that were independent of the reduction of blood pressure. We have previously shown that vulner- able hippocampal CA1 neurons underwent delayed cell death through mitochondria-dependent apoptotic pathway after global cerebral ischemia, but ARB protected these neurons from cell death. To elucidate the mechanism of neuroprotection by ARB candesartan, candesartan-specific binding proteins were first investigated using candesartan-affinity column and rat hippocampal tissue. And, the affinity of ARB and the binding protein was further examined by BIAcore binding assay. Then, the distribution and expression of the protein were characterized by immunohisotochemis- try and Western blots. By affinity column study, molecular chaperone heat shock protein 90 (HSP90) was identified as a binding target of candesartan. BIAcore assay proved functional binding of candesartan to HSP90. Immunohistochemistry showed increased HSP90 expression in the hippocampal CA1 neurons as early as 1 day after candesartan treatment. Westen blots confirmed temporal changes in HSP90 expression. HSP90 maintains the stability of the proteins as a molecular chaperone and has been recently proven to inhibit apoptosis in in vitro studies. Our data suggest that HSP90 may play an impor- tant role in neuronal protection by ARB treatment through blocking mitochondria-dependent apoptosis." @default.
• W2138509148 created "2016-06-24" @default.
• W2138509148 creator A5005404074 @default.
• W2138509148 creator A5024119860 @default.
• W2138509148 creator A5034739026 @default.
• W2138509148 creator A5039699220 @default.
• W2138509148 creator A5056808627 @default.
• W2138509148 creator A5072664282 @default.
• W2138509148 date "2009-01-01" @default.
• W2138509148 modified "2023-09-26" @default.
• W2138509148 title "ANGIOTENSIN RECEPTOR BLOCKER CANDESARTAN BINDS TO AND UPREGULATES MOLECULAR CHAPERONE HSP90 IN THE HIPPOCAMPAL CA1 NEURONS ― A POSSIBLE MECHANISM OF NEUROPROTECTION BY ANGIOTENSIN RECEPTOR BLOCKER―" @default.
• W2138509148 cites W1566676785 @default.
• W2138509148 cites W1598830628 @default.
• W2138509148 cites W1690631198 @default.
• W2138509148 cites W1706238475 @default.
• W2138509148 cites W1857709346 @default.
• W2138509148 cites W1965478593 @default.
• W2138509148 cites W1965774334 @default.
• W2138509148 cites W1994501076 @default.
• W2138509148 cites W1999938778 @default.
• W2138509148 cites W2000155150 @default.
• W2138509148 cites W2003666655 @default.
• W2138509148 cites W2015843046 @default.
• W2138509148 cites W2028581882 @default.
• W2138509148 cites W2050797367 @default.
• W2138509148 cites W2058738942 @default.
• W2138509148 cites W2061497413 @default.
• W2138509148 cites W2070942807 @default.
• W2138509148 cites W2086199925 @default.
• W2138509148 cites W2087254050 @default.
• W2138509148 cites W2087689873 @default.
• W2138509148 cites W2094971529 @default.
• W2138509148 cites W2096966529 @default.
• W2138509148 cites W2100837269 @default.
• W2138509148 cites W2101108802 @default.
• W2138509148 cites W2107005606 @default.
• W2138509148 cites W2116991275 @default.
• W2138509148 cites W2119874123 @default.
• W2138509148 cites W2133217116 @default.
• W2138509148 cites W2146798390 @default.
• W2138509148 cites W2157999078 @default.
• W2138509148 cites W2158892872 @default.
• W2138509148 cites W2160722137 @default.
• W2138509148 cites W2166507618 @default.
• W2138509148 cites W2170806182 @default.
• W2138509148 cites W2399434312 @default.
• W2138509148 hasPublicationYear "2009" @default.
• W2138509148 type Work @default.
• W2138509148 sameAs 2138509148 @default.
• W2138509148 citedByCount "0" @default.
• W2138509148 crossrefType "journal-article" @default.
• W2138509148 hasAuthorship W2138509148A5005404074 @default.
• W2138509148 hasAuthorship W2138509148A5024119860 @default.
• W2138509148 hasAuthorship W2138509148A5034739026 @default.
• W2138509148 hasAuthorship W2138509148A5039699220 @default.
• W2138509148 hasAuthorship W2138509148A5056808627 @default.
• W2138509148 hasAuthorship W2138509148A5072664282 @default.
• W2138509148 hasConcept C104317684 @default.
• W2138509148 hasConcept C104849204 @default.
• W2138509148 hasConcept C134018914 @default.
• W2138509148 hasConcept C142724271 @default.
• W2138509148 hasConcept C148762608 @default.
• W2138509148 hasConcept C170493617 @default.
• W2138509148 hasConcept C185592680 @default.
• W2138509148 hasConcept C205260736 @default.
• W2138509148 hasConcept C25498285 @default.
• W2138509148 hasConcept C2775932338 @default.
• W2138509148 hasConcept C2775962898 @default.
• W2138509148 hasConcept C2780036600 @default.
• W2138509148 hasConcept C2908929049 @default.
• W2138509148 hasConcept C55493867 @default.
• W2138509148 hasConcept C68991219 @default.
• W2138509148 hasConcept C71924100 @default.
• W2138509148 hasConcept C86803240 @default.
• W2138509148 hasConcept C95444343 @default.
• W2138509148 hasConcept C98274493 @default.
• W2138509148 hasConceptScore W2138509148C104317684 @default.
• W2138509148 hasConceptScore W2138509148C104849204 @default.
• W2138509148 hasConceptScore W2138509148C134018914 @default.
• W2138509148 hasConceptScore W2138509148C142724271 @default.
• W2138509148 hasConceptScore W2138509148C148762608 @default.
• W2138509148 hasConceptScore W2138509148C170493617 @default.
• W2138509148 hasConceptScore W2138509148C185592680 @default.
• W2138509148 hasConceptScore W2138509148C205260736 @default.
• W2138509148 hasConceptScore W2138509148C25498285 @default.
• W2138509148 hasConceptScore W2138509148C2775932338 @default.
• W2138509148 hasConceptScore W2138509148C2775962898 @default.
• W2138509148 hasConceptScore W2138509148C2780036600 @default.
• W2138509148 hasConceptScore W2138509148C2908929049 @default.
• W2138509148 hasConceptScore W2138509148C55493867 @default.
• W2138509148 hasConceptScore W2138509148C68991219 @default.
• W2138509148 hasConceptScore W2138509148C71924100 @default.
• W2138509148 hasConceptScore W2138509148C86803240 @default.
• W2138509148 hasConceptScore W2138509148C95444343 @default.
• W2138509148 hasConceptScore W2138509148C98274493 @default.
• W2138509148 hasIssue "1" @default.
• W2138509148 hasLocation W21385091481 @default.
• W2138509148 hasOpenAccess W2138509148 @default.

• next