Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138522077> ?p ?o ?g. }
- W2138522077 endingPage "3446" @default.
- W2138522077 startingPage "3437" @default.
- W2138522077 abstract "Kisspeptins (Kiss1 and Kiss2) and their receptors (putatively Gpr54-1 and Gpr54-2) have emerged as key players in vertebrate reproduction owing to their stimulatory effect on the brain-pituitary-gonadal axis. Virtually nothing is known, however, about their role during embryogenesis. Using medaka (Teleostei) as a model system, we report, for the first time in vertebrates, an early developmental expression and putative function of kisspeptins. Expression analyses and knockdown experiments suggest that early actions of kisspeptins are probably mediated by binding to maternally supplied Gpr54-1 and late action by both Gpr54-1 and Gpr54-2. Knockdown of maternally provided kiss1 and gpr54-1 arrested development during gastrulation, before establishment of any germ layers, whereas knockdown of zygotically provided kiss1 and gpr54-1 disrupted brain development. A similar phenotype was observed for gpr54-2 knockdown embryos, suggesting a critical role for kiss1, gpr54-1, and gpr54-2 in neurulation. These data demonstrate that kisspeptin signaling is active both maternally and zygotically and is involved in embryonic survival and morphogenesis." @default.
- W2138522077 created "2016-06-24" @default.
- W2138522077 creator A5007750182 @default.
- W2138522077 creator A5035617867 @default.
- W2138522077 creator A5047560823 @default.
- W2138522077 creator A5065259494 @default.
- W2138522077 date "2013-07-03" @default.
- W2138522077 modified "2023-10-13" @default.
- W2138522077 title "Expression and Putative Function of Kisspeptins and Their Receptors During Early Development in Medaka" @default.
- W2138522077 cites W1510791389 @default.
- W2138522077 cites W1707907726 @default.
- W2138522077 cites W1880891411 @default.
- W2138522077 cites W1898552202 @default.
- W2138522077 cites W1963483307 @default.
- W2138522077 cites W1963716701 @default.
- W2138522077 cites W1964782601 @default.
- W2138522077 cites W1969670014 @default.
- W2138522077 cites W1975310201 @default.
- W2138522077 cites W1982117519 @default.
- W2138522077 cites W2007985990 @default.
- W2138522077 cites W2008674540 @default.
- W2138522077 cites W2011676634 @default.
- W2138522077 cites W2016690346 @default.
- W2138522077 cites W2026978970 @default.
- W2138522077 cites W2027799859 @default.
- W2138522077 cites W2032695937 @default.
- W2138522077 cites W2032781486 @default.
- W2138522077 cites W2040020955 @default.
- W2138522077 cites W2043092239 @default.
- W2138522077 cites W2050154239 @default.
- W2138522077 cites W2050671574 @default.
- W2138522077 cites W2050825501 @default.
- W2138522077 cites W2056162352 @default.
- W2138522077 cites W2058435755 @default.
- W2138522077 cites W2060648566 @default.
- W2138522077 cites W2062591635 @default.
- W2138522077 cites W2080762932 @default.
- W2138522077 cites W2081114661 @default.
- W2138522077 cites W2086093927 @default.
- W2138522077 cites W2086370832 @default.
- W2138522077 cites W2094530722 @default.
- W2138522077 cites W2096251733 @default.
- W2138522077 cites W2097336373 @default.
- W2138522077 cites W2098509726 @default.
- W2138522077 cites W2105936590 @default.
- W2138522077 cites W2110757850 @default.
- W2138522077 cites W2111338104 @default.
- W2138522077 cites W2111746645 @default.
- W2138522077 cites W2111824942 @default.
- W2138522077 cites W2114996423 @default.
- W2138522077 cites W2116172438 @default.
- W2138522077 cites W2117747320 @default.
- W2138522077 cites W2123939470 @default.
- W2138522077 cites W2128086758 @default.
- W2138522077 cites W2132074057 @default.
- W2138522077 cites W2142539951 @default.
- W2138522077 cites W2142686356 @default.
- W2138522077 cites W2143506157 @default.
- W2138522077 cites W2151613225 @default.
- W2138522077 cites W2170736109 @default.
- W2138522077 doi "https://doi.org/10.1210/en.2013-1065" @default.
- W2138522077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23825126" @default.
- W2138522077 hasPublicationYear "2013" @default.
- W2138522077 type Work @default.
- W2138522077 sameAs 2138522077 @default.
- W2138522077 citedByCount "26" @default.
- W2138522077 countsByYear W21385220772014 @default.
- W2138522077 countsByYear W21385220772015 @default.
- W2138522077 countsByYear W21385220772016 @default.
- W2138522077 countsByYear W21385220772017 @default.
- W2138522077 countsByYear W21385220772018 @default.
- W2138522077 countsByYear W21385220772019 @default.
- W2138522077 countsByYear W21385220772020 @default.
- W2138522077 countsByYear W21385220772021 @default.
- W2138522077 countsByYear W21385220772022 @default.
- W2138522077 countsByYear W21385220772023 @default.
- W2138522077 crossrefType "journal-article" @default.
- W2138522077 hasAuthorship W2138522077A5007750182 @default.
- W2138522077 hasAuthorship W2138522077A5035617867 @default.
- W2138522077 hasAuthorship W2138522077A5047560823 @default.
- W2138522077 hasAuthorship W2138522077A5065259494 @default.
- W2138522077 hasBestOaLocation W21385220771 @default.
- W2138522077 hasConcept C104317684 @default.
- W2138522077 hasConcept C126322002 @default.
- W2138522077 hasConcept C129536746 @default.
- W2138522077 hasConcept C134018914 @default.
- W2138522077 hasConcept C170493617 @default.
- W2138522077 hasConcept C173396325 @default.
- W2138522077 hasConcept C196843134 @default.
- W2138522077 hasConcept C2776808119 @default.
- W2138522077 hasConcept C54355233 @default.
- W2138522077 hasConcept C71924100 @default.
- W2138522077 hasConcept C86803240 @default.
- W2138522077 hasConcept C87073359 @default.
- W2138522077 hasConcept C95444343 @default.
- W2138522077 hasConceptScore W2138522077C104317684 @default.
- W2138522077 hasConceptScore W2138522077C126322002 @default.
- W2138522077 hasConceptScore W2138522077C129536746 @default.