Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138523931> ?p ?o ?g. }
- W2138523931 endingPage "7" @default.
- W2138523931 startingPage "2840" @default.
- W2138523931 abstract "Spontaneously immortalized human skin keratinocytes (HaCaT) were transfected with the c-Ha-ras (EJ) oncogene via a plasmid construct which also contained the selectable neomycin gene. Clones were selected on the basis of G418 resistance. Those clones that had stable integrants of Ha-ras fell into 3 classes with respect to tumorigenicity. Class I clones were nontumorigenic, i.e., formed nodules which rapidly regressed. This phenotype is identical to that seen with parental HaCaT cells. Class II clones formed slowly growing, highly differentiated cystic or papillomatous-type benign tumors, and class III clones formed highly differentiated, locally invasive squamous cell carcinomas. The clones of all three classes exhibited similar morphology and growth potential in culture and retained the ability to reconstitute an epidermis-like stratified epithelium in transplantation experiments. Only the malignant clones showed locally invasive growth. Both the benign and the malignant clones exhibited higher levels of ras integration and variable levels of mutated p21 protein product. Thus, expression of the cellular Ha-ras oncogene in these human epithelial cells significantly altered growth regulation, resulting in varying degrees of growth potential in vivo, ranging from benign to malignant tumors. However, no direct correlation was seen between high levels of p21 expression and malignant growth." @default.
- W2138523931 created "2016-06-24" @default.
- W2138523931 creator A5004702190 @default.
- W2138523931 creator A5052269548 @default.
- W2138523931 creator A5061367016 @default.
- W2138523931 creator A5063856596 @default.
- W2138523931 creator A5068941302 @default.
- W2138523931 date "1990-05-01" @default.
- W2138523931 modified "2023-09-26" @default.
- W2138523931 title "c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy." @default.
- W2138523931 cites W11596768 @default.
- W2138523931 cites W150580531 @default.
- W2138523931 cites W1552544560 @default.
- W2138523931 cites W1581325718 @default.
- W2138523931 cites W1588885776 @default.
- W2138523931 cites W1596418087 @default.
- W2138523931 cites W1796075769 @default.
- W2138523931 cites W1804112400 @default.
- W2138523931 cites W1817017058 @default.
- W2138523931 cites W1957539018 @default.
- W2138523931 cites W1968870498 @default.
- W2138523931 cites W1982263288 @default.
- W2138523931 cites W1984240546 @default.
- W2138523931 cites W1987212762 @default.
- W2138523931 cites W1989009382 @default.
- W2138523931 cites W1991320113 @default.
- W2138523931 cites W1992405600 @default.
- W2138523931 cites W1995723368 @default.
- W2138523931 cites W2001923549 @default.
- W2138523931 cites W2009835155 @default.
- W2138523931 cites W2016241323 @default.
- W2138523931 cites W2016435958 @default.
- W2138523931 cites W2017095060 @default.
- W2138523931 cites W2019392946 @default.
- W2138523931 cites W2023335056 @default.
- W2138523931 cites W2027789831 @default.
- W2138523931 cites W2028519621 @default.
- W2138523931 cites W2035706724 @default.
- W2138523931 cites W2044014221 @default.
- W2138523931 cites W2052830851 @default.
- W2138523931 cites W2066647186 @default.
- W2138523931 cites W2069100534 @default.
- W2138523931 cites W2071697240 @default.
- W2138523931 cites W2073006672 @default.
- W2138523931 cites W2084099638 @default.
- W2138523931 cites W2087411905 @default.
- W2138523931 cites W2088130891 @default.
- W2138523931 cites W2094226908 @default.
- W2138523931 cites W2100837269 @default.
- W2138523931 cites W2101108802 @default.
- W2138523931 cites W2117079180 @default.
- W2138523931 cites W2118929543 @default.
- W2138523931 cites W2118989941 @default.
- W2138523931 cites W2121428853 @default.
- W2138523931 cites W2122679701 @default.
- W2138523931 cites W2143464311 @default.
- W2138523931 cites W2152195298 @default.
- W2138523931 cites W2167105480 @default.
- W2138523931 cites W2167202601 @default.
- W2138523931 cites W2256796429 @default.
- W2138523931 cites W2400589564 @default.
- W2138523931 cites W2414740817 @default.
- W2138523931 cites W2440641407 @default.
- W2138523931 cites W27510651 @default.
- W2138523931 cites W2164081446 @default.
- W2138523931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2183932" @default.
- W2138523931 hasPublicationYear "1990" @default.
- W2138523931 type Work @default.
- W2138523931 sameAs 2138523931 @default.
- W2138523931 citedByCount "69" @default.
- W2138523931 countsByYear W21385239312012 @default.
- W2138523931 countsByYear W21385239312013 @default.
- W2138523931 countsByYear W21385239312014 @default.
- W2138523931 countsByYear W21385239312015 @default.
- W2138523931 countsByYear W21385239312016 @default.
- W2138523931 countsByYear W21385239312017 @default.
- W2138523931 countsByYear W21385239312018 @default.
- W2138523931 countsByYear W21385239312019 @default.
- W2138523931 countsByYear W21385239312020 @default.
- W2138523931 countsByYear W21385239312022 @default.
- W2138523931 crossrefType "journal-article" @default.
- W2138523931 hasAuthorship W2138523931A5004702190 @default.
- W2138523931 hasAuthorship W2138523931A5052269548 @default.
- W2138523931 hasAuthorship W2138523931A5061367016 @default.
- W2138523931 hasAuthorship W2138523931A5063856596 @default.
- W2138523931 hasAuthorship W2138523931A5068941302 @default.
- W2138523931 hasConcept C104317684 @default.
- W2138523931 hasConcept C105702510 @default.
- W2138523931 hasConcept C118995209 @default.
- W2138523931 hasConcept C127716648 @default.
- W2138523931 hasConcept C1491633281 @default.
- W2138523931 hasConcept C153911025 @default.
- W2138523931 hasConcept C207001950 @default.
- W2138523931 hasConcept C2776458125 @default.
- W2138523931 hasConcept C2777074287 @default.
- W2138523931 hasConcept C2781018059 @default.
- W2138523931 hasConcept C29537977 @default.
- W2138523931 hasConcept C31033888 @default.