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- W213852854 abstract "Objective To study the role of the loss of heterozygosity(LOH)on the chromosome 8p22 in the occurrence and development of the chronic myeloid leukemia(CML).Method The LOH was observed in two microsatellite markers including D8S511 and D8S258 on 8p22 using polymerase chain reaction(PCR)amplification.Result No LOH on D8S511 and D8S258 occurred in 30 CML patients at chronic phase and accelerated phase.Also,no LOH on D8S511 occurred in 4 CML patients at blast crisis except the appearance of LOH on D8S258 in one patient.None of 5 normal controls had LOH.Conclusion The LOH on D8S511 within 8p22 is not correlated with the occurrence and development of CML at all stages.The LOH on D8S258 is not correlated with the occurrence and development of CML at chronic and accelerated phase,but may play a role in the acute transformation of CML." @default.
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- W213852854 date "2009-01-01" @default.
- W213852854 modified "2023-09-26" @default.
- W213852854 title "Detection and significance of loss of heterozygosity on 8p22 in chronic myeloid leukemia." @default.
- W213852854 hasPublicationYear "2009" @default.
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