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• W2138535288 abstract "Autoimmune diseases like multiple sclerosis (MS) and inflammatory bowel disease (IBD) occur because of an inappropriate immune-mediated attack against self-tissue. Analyses of genetically identical twins shows that besides genetics there are important environmental factors that contribute to MS and IBD development. Vitamin D availability due to sunshine exposure or diet may play a role in the development of MS and IBD. Compelling data in mice show that vitamin D and signaling through the vitamin D receptor dictate the outcome of experimental MS and IBD. Furthermore, the evidence points to the direct and indirect regulation of T cell development and function by vitamin D. In the absence of vitamin D and signals delivered through the vitamin D receptor, auto reactive T cells develop and in the presence of active vitamin D (1,25(OH)2D3 ) and a functional vitamin D receptor the balance in the T cell response is restored and autoimmunity avoided." @default.
• W2138535288 created "2016-06-24" @default.
• W2138535288 creator A5059431026 @default.
• W2138535288 date "2006-09-01" @default.
• W2138535288 modified "2023-10-09" @default.
• W2138535288 title "Vitamin D and its role in immunology: Multiple sclerosis, and inflammatory bowel disease" @default.
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• W2138535288 doi "https://doi.org/10.1016/j.pbiomolbio.2006.02.020" @default.
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