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• W2138591665 startingPage "1182" @default.
• W2138591665 abstract "ABSTRACT Pertussis is an acute respiratory disease caused by the bacterium Bordetella pertussis , for which humans are the only known reservoir. During infection, B. pertussis releases several toxins, including pertussis toxin (PT) and adenylate cyclase toxin (ACT), which have both been shown to play roles in promoting bacterial growth during early infection in a mouse model. Furthermore, in vitro and in vivo studies suggest that PT and ACT affect neutrophil chemotaxis and/or function, thereby altering the innate immune response. In this study we depleted animals of neutrophils to investigate whether neutrophils play a protective role during B. pertussis infection in mice. In addition, by infection with toxin-deficient strains, we investigated whether neutrophils are the main targets for PT and/or ACT activity in promoting bacterial growth. Surprisingly, we found no role for neutrophils during B. pertussis infection in naïve mice. However, in previously infected (immune) mice or in mice receiving immune serum, we observed a significant role for neutrophils during infection. Furthermore, in this immune mouse model our evidence indicates that neutrophils appear to be the main target cells for ACT, but not for PT." @default.
• W2138591665 created "2016-06-24" @default.
• W2138591665 creator A5074914091 @default.
• W2138591665 creator A5077507710 @default.
• W2138591665 date "2009-03-01" @default.
• W2138591665 modified "2023-10-04" @default.
• W2138591665 title "Role of Neutrophils in Response to<i>Bordetella pertussis</i>Infection in Mice" @default.
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• W2138591665 doi "https://doi.org/10.1128/iai.01150-08" @default.
• W2138591665 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2643619" @default.
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• W2138591665 hasPublicationYear "2009" @default.
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