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- W2138595087 abstract "In this study, a known inducer of heme oxygenase-1 (HO-1) expression, cobalt protoporphyrin, and the introduction of a recombinant plasmid expressing HO-1 were examined for their ability to protect gastric epithelial cells from deoxycholate-induced injury. Physiologic levels of the secondary bile salt induce apoptosis in a human gastric adenocarcinoma mucosal cell line. Cobalt protoporphyrin induced expression of HO-1 protein with maximal levels attaining a plateau at 48 hours. Pretreatment with cobalt protoporphyrin before challenge with 200 μM deoxycholate inhibited cell death, DNA fragmentation, the appearance of cytosolic nucleosomes, and cleavage of caspase-3, caspase-9, and poly-(ADP-ribose) polymerase 1. Similarly, expression of HO-1 by introduction of a recombinant plasmid also showed a resistance to deoxycholate-induced apoptosis. These results implicate a possible role for HO-1 in modulating apoptosis in gastric epithelial cells." @default.
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- W2138595087 date "2011-03-01" @default.
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- W2138595087 title "Preconditioning with cobalt protoporphyrin protects human gastric mucosal cells from deoxycholate-induced apoptosis" @default.
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- W2138595087 doi "https://doi.org/10.1111/j.1524-475x.2010.00661.x" @default.
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