FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138596564> ?p ?o ?g. }

• W2138596564 endingPage "4797" @default.
• W2138596564 startingPage "4788" @default.
• W2138596564 abstract "Glucocorticoid receptor (GR) is cytoplasmic in the absence of ligand and localizes to the nucleus after steroid binding. Previous evidence demonstrated that the hsp90-based heterocomplex bound to GR is required for the efficient retrotransport of the receptor to the nuclear compartment. We examined the putative association of GR and its associated chaperone heterocomplex with structures of the nuclear pore. We found that importin β and the integral nuclear pore glycoprotein Nup62 interact with hsp90, hsp70, p23, and the TPR domain proteins FKBP52 and PP5. Nup62 and GR were able to interact in a more efficient manner when chaperoned by the hsp90-based heterocomplex. Interestingly, the binding of hsp70 and p23 to Nup62 does not require the presence of hsp90, whereas the association of FKBP52 and PP5 is hsp90 dependent, as indicated by the results of experiments where the hsp90 function was disrupted with radicicol. The ability of both FKBP52 and PP5 to interact with Nup62 was abrogated in cells overexpressing the TPR peptide. Importantly, GR cross-linked to the hsp90 heterocomplex was able to translocate to the nucleus in digitonin-permeabilized cells treated with steroid, suggesting that GR could pass through the pore in its untransformed state." @default.
• W2138596564 created "2016-06-24" @default.
• W2138596564 creator A5024989958 @default.
• W2138596564 creator A5025282831 @default.
• W2138596564 creator A5036948916 @default.
• W2138596564 creator A5041414348 @default.
• W2138596564 creator A5072652265 @default.
• W2138596564 creator A5091782412 @default.
• W2138596564 date "2009-09-01" @default.
• W2138596564 modified "2023-10-06" @default.
• W2138596564 title "Nuclear Import of the Glucocorticoid Receptor-hsp90 Complex through the Nuclear Pore Complex Is Mediated by Its Interaction with Nup62 and Importin β" @default.
• W2138596564 cites W1213045642 @default.
• W2138596564 cites W142850513 @default.
• W2138596564 cites W1505062366 @default.
• W2138596564 cites W1526495196 @default.
• W2138596564 cites W1597403892 @default.
• W2138596564 cites W1963563355 @default.
• W2138596564 cites W1963770237 @default.
• W2138596564 cites W1968235572 @default.
• W2138596564 cites W1968975193 @default.
• W2138596564 cites W1974793156 @default.
• W2138596564 cites W1974841112 @default.
• W2138596564 cites W1978754402 @default.
• W2138596564 cites W1990534307 @default.
• W2138596564 cites W2007323865 @default.
• W2138596564 cites W2008733010 @default.
• W2138596564 cites W2009975411 @default.
• W2138596564 cites W2010400928 @default.
• W2138596564 cites W2015426324 @default.
• W2138596564 cites W2024821272 @default.
• W2138596564 cites W2026202026 @default.
• W2138596564 cites W2026203588 @default.
• W2138596564 cites W2026911087 @default.
• W2138596564 cites W2037652621 @default.
• W2138596564 cites W2040029052 @default.
• W2138596564 cites W2041561339 @default.
• W2138596564 cites W2048492672 @default.
• W2138596564 cites W2051923922 @default.
• W2138596564 cites W2053497997 @default.
• W2138596564 cites W2055938892 @default.
• W2138596564 cites W2056613530 @default.
• W2138596564 cites W2058560641 @default.
• W2138596564 cites W2063616586 @default.
• W2138596564 cites W2063717615 @default.
• W2138596564 cites W2065295359 @default.
• W2138596564 cites W2072109709 @default.
• W2138596564 cites W2081158713 @default.
• W2138596564 cites W2090639114 @default.
• W2138596564 cites W2096774529 @default.
• W2138596564 cites W2101440792 @default.
• W2138596564 cites W2103079100 @default.
• W2138596564 cites W2121877938 @default.
• W2138596564 cites W2132034930 @default.
• W2138596564 cites W2139317494 @default.
• W2138596564 cites W2143103923 @default.
• W2138596564 cites W2143566830 @default.
• W2138596564 cites W2150359450 @default.
• W2138596564 cites W2151298994 @default.
• W2138596564 cites W2164328371 @default.
• W2138596564 cites W2164918994 @default.
• W2138596564 cites W2167613565 @default.
• W2138596564 cites W2171230661 @default.
• W2138596564 cites W4241255166 @default.
• W2138596564 doi "https://doi.org/10.1128/mcb.00649-09" @default.
• W2138596564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2725705" @default.
• W2138596564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19581287" @default.
• W2138596564 hasPublicationYear "2009" @default.
• W2138596564 type Work @default.
• W2138596564 sameAs 2138596564 @default.
• W2138596564 citedByCount "130" @default.
• W2138596564 countsByYear W21385965642012 @default.
• W2138596564 countsByYear W21385965642013 @default.
• W2138596564 countsByYear W21385965642014 @default.
• W2138596564 countsByYear W21385965642015 @default.
• W2138596564 countsByYear W21385965642016 @default.
• W2138596564 countsByYear W21385965642017 @default.
• W2138596564 countsByYear W21385965642018 @default.
• W2138596564 countsByYear W21385965642019 @default.
• W2138596564 countsByYear W21385965642020 @default.
• W2138596564 countsByYear W21385965642021 @default.
• W2138596564 countsByYear W21385965642022 @default.
• W2138596564 countsByYear W21385965642023 @default.
• W2138596564 crossrefType "journal-article" @default.
• W2138596564 hasAuthorship W2138596564A5024989958 @default.
• W2138596564 hasAuthorship W2138596564A5025282831 @default.
• W2138596564 hasAuthorship W2138596564A5036948916 @default.
• W2138596564 hasAuthorship W2138596564A5041414348 @default.
• W2138596564 hasAuthorship W2138596564A5072652265 @default.
• W2138596564 hasAuthorship W2138596564A5091782412 @default.
• W2138596564 hasBestOaLocation W21385965641 @default.
• W2138596564 hasConcept C104317684 @default.
• W2138596564 hasConcept C126725582 @default.
• W2138596564 hasConcept C133882971 @default.
• W2138596564 hasConcept C142724271 @default.
• W2138596564 hasConcept C170493617 @default.
• W2138596564 hasConcept C190062978 @default.
• W2138596564 hasConcept C205260736 @default.
• W2138596564 hasConcept C2775932338 @default.

• next