FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138602562> ?p ?o ?g. }

• W2138602562 abstract "Both transcriptional activation and repression have essential functions in maintaining proper spatial and temporal control of gene expression. Although Wnt signalling is often associated with gene activation, we have identified several directly repressed targets of Wnt signalling in Drosophila. Here, we explore how individual Wnt target genes are specified for signal-induced activation or repression. Similar to activation, repression required binding of Armadillo (Arm) to the N terminus of TCF. However, TCF/Arm mediated repression by binding to DNA motifs that are markedly different from typical TCF-binding sites. Conversion of the novel motifs to standard TCF-binding sites reversed the mode of regulation, resulting in Wnt-mediated activation instead of repression. A mutant form of Arm defective in activation was still functional for repression, indicating that distinct domains of the protein are required for each activity. This study suggests that the sequence of TCF-binding sites allosterically regulates the TCF/Arm complex to effect either transcriptional activation or repression." @default.
• W2138602562 created "2016-06-24" @default.
• W2138602562 creator A5027246192 @default.
• W2138602562 creator A5039136921 @default.
• W2138602562 creator A5071156868 @default.
• W2138602562 date "2008-04-17" @default.
• W2138602562 modified "2023-10-03" @default.
• W2138602562 title "Novel TCF-binding sites specify transcriptional repression by Wnt signalling" @default.
• W2138602562 cites W107516422 @default.
• W2138602562 cites W11746948 @default.
• W2138602562 cites W1525122215 @default.
• W2138602562 cites W1536067283 @default.
• W2138602562 cites W1596316114 @default.
• W2138602562 cites W1632044028 @default.
• W2138602562 cites W1883735868 @default.
• W2138602562 cites W1901013657 @default.
• W2138602562 cites W1975853332 @default.
• W2138602562 cites W1978957229 @default.
• W2138602562 cites W1988396057 @default.
• W2138602562 cites W1997641930 @default.
• W2138602562 cites W2004823255 @default.
• W2138602562 cites W2008448536 @default.
• W2138602562 cites W2011684758 @default.
• W2138602562 cites W2011915378 @default.
• W2138602562 cites W2012598468 @default.
• W2138602562 cites W2017780187 @default.
• W2138602562 cites W2018804425 @default.
• W2138602562 cites W2020712616 @default.
• W2138602562 cites W2022120062 @default.
• W2138602562 cites W2024641801 @default.
• W2138602562 cites W2025853036 @default.
• W2138602562 cites W2029475329 @default.
• W2138602562 cites W2030115768 @default.
• W2138602562 cites W2034141930 @default.
• W2138602562 cites W2038087401 @default.
• W2138602562 cites W2038228771 @default.
• W2138602562 cites W2039424163 @default.
• W2138602562 cites W2040289871 @default.
• W2138602562 cites W2041498658 @default.
• W2138602562 cites W2045655335 @default.
• W2138602562 cites W2051782048 @default.
• W2138602562 cites W2054518774 @default.
• W2138602562 cites W2054652369 @default.
• W2138602562 cites W2058718835 @default.
• W2138602562 cites W2063620691 @default.
• W2138602562 cites W2077479555 @default.
• W2138602562 cites W2079677766 @default.
• W2138602562 cites W2099105062 @default.
• W2138602562 cites W2100070586 @default.
• W2138602562 cites W2110643873 @default.
• W2138602562 cites W2119284420 @default.
• W2138602562 cites W2128016314 @default.
• W2138602562 cites W2129910671 @default.
• W2138602562 cites W2138753762 @default.
• W2138602562 cites W2141175150 @default.
• W2138602562 cites W2146778778 @default.
• W2138602562 cites W2152123530 @default.
• W2138602562 cites W2154473845 @default.
• W2138602562 cites W2156575042 @default.
• W2138602562 cites W2158079348 @default.
• W2138602562 cites W2158092584 @default.
• W2138602562 cites W2162295076 @default.
• W2138602562 cites W2164267451 @default.
• W2138602562 cites W2169056802 @default.
• W2138602562 cites W2171585060 @default.
• W2138602562 cites W2171996338 @default.
• W2138602562 cites W2181895408 @default.
• W2138602562 cites W4243920156 @default.
• W2138602562 doi "https://doi.org/10.1038/emboj.2008.80" @default.
• W2138602562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2396397" @default.
• W2138602562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18418383" @default.
• W2138602562 hasPublicationYear "2008" @default.
• W2138602562 type Work @default.
• W2138602562 sameAs 2138602562 @default.
• W2138602562 citedByCount "56" @default.
• W2138602562 countsByYear W21386025622012 @default.
• W2138602562 countsByYear W21386025622014 @default.
• W2138602562 countsByYear W21386025622015 @default.
• W2138602562 countsByYear W21386025622016 @default.
• W2138602562 countsByYear W21386025622017 @default.
• W2138602562 countsByYear W21386025622018 @default.
• W2138602562 countsByYear W21386025622019 @default.
• W2138602562 countsByYear W21386025622020 @default.
• W2138602562 countsByYear W21386025622021 @default.
• W2138602562 countsByYear W21386025622022 @default.
• W2138602562 countsByYear W21386025622023 @default.
• W2138602562 crossrefType "journal-article" @default.
• W2138602562 hasAuthorship W2138602562A5027246192 @default.
• W2138602562 hasAuthorship W2138602562A5039136921 @default.
• W2138602562 hasAuthorship W2138602562A5071156868 @default.
• W2138602562 hasBestOaLocation W21386025621 @default.
• W2138602562 hasConcept C104317684 @default.
• W2138602562 hasConcept C107824862 @default.
• W2138602562 hasConcept C137620995 @default.
• W2138602562 hasConcept C150194340 @default.
• W2138602562 hasConcept C158448853 @default.
• W2138602562 hasConcept C165864922 @default.
• W2138602562 hasConcept C186310378 @default.
• W2138602562 hasConcept C54355233 @default.
• W2138602562 hasConcept C86339819 @default.

• next