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- W2138643360 abstract "NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a) are potent anticonvulsant agents, and display strong protective effects in the electroshock-induced convulsion assay in mice. Their preference for the human NMDAR 1A/2A over 1A/2B subunit composition was optimized, leading to (1RS,1'S)-PEAQX (9r), which shows a >100-fold selectivity." @default.
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- W2138643360 date "2002-04-01" @default.
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- W2138643360 title "5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition" @default.
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- W2138643360 doi "https://doi.org/10.1016/s0960-894x(02)00074-4" @default.
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