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- W2138678864 abstract "Diabetes is a mutifactorial metabolic disorder that leads to a number of complications. Diabetes is estimated to affect 36 million people in the U.S.A., and the prevalence of diagnosed and undiagnosed diabetes is at 9.3% and continues to rise. Evidence from experimental animal models as well as humans has indicated that systemic inflammation plays a role in the pathophysiological processes of diabetes and is facilitated by innate immune responses. TLRs (Toll-like receptors) are key innate immune receptors that recognize conserved PAMPs (pathogen-associated molecular patterns), induce inflammatory responses essential for host defences and initiate an adaptive immune response. Although TLR expression is increased in a plethora of inflammatory disorders, the effects of metabolic aberrations on TLRs and their role in diabetes and its complications is still emerging. In the present paper, we provide a systematic review on how TLRs play a detrimental role in the pathogenic processes [increased blood sugar, NEFAs (non-esterified ‘free’ fatty acids), cytokines and ROS (reactive oxygen species)] that manifest diabetes. Furthermore, we will highlight some of the therapeutic strategies targeted at decreasing TLRs to abrogate inflammation in diabetes that may eventually result in decreased complications." @default.
- W2138678864 created "2016-06-24" @default.
- W2138678864 creator A5003213972 @default.
- W2138678864 creator A5032304852 @default.
- W2138678864 creator A5043741960 @default.
- W2138678864 date "2011-10-28" @default.
- W2138678864 modified "2023-09-25" @default.
- W2138678864 title "Toll-like receptors and diabetes: a therapeutic perspective" @default.
- W2138678864 cites W1490802705 @default.
- W2138678864 cites W1529592271 @default.
- W2138678864 cites W1550399013 @default.
- W2138678864 cites W1558213119 @default.
- W2138678864 cites W1586099293 @default.
- W2138678864 cites W1720483047 @default.
- W2138678864 cites W1938589063 @default.
- W2138678864 cites W1963913523 @default.
- W2138678864 cites W1967053946 @default.
- W2138678864 cites W1967172766 @default.
- W2138678864 cites W1968693059 @default.
- W2138678864 cites W1970106273 @default.
- W2138678864 cites W1974092523 @default.
- W2138678864 cites W1975090164 @default.
- W2138678864 cites W1976763513 @default.
- W2138678864 cites W1979598489 @default.
- W2138678864 cites W1980763614 @default.
- W2138678864 cites W1981357380 @default.
- W2138678864 cites W1981533568 @default.
- W2138678864 cites W1983486452 @default.
- W2138678864 cites W1984513597 @default.
- W2138678864 cites W1988334706 @default.
- W2138678864 cites W1990902267 @default.
- W2138678864 cites W1991630392 @default.
- W2138678864 cites W1995569625 @default.
- W2138678864 cites W1998221258 @default.
- W2138678864 cites W1999523285 @default.
- W2138678864 cites W2002172988 @default.
- W2138678864 cites W2002225831 @default.
- W2138678864 cites W2003276740 @default.
- W2138678864 cites W2004773897 @default.
- W2138678864 cites W2006721421 @default.
- W2138678864 cites W2010572052 @default.
- W2138678864 cites W2013469022 @default.
- W2138678864 cites W2013742341 @default.
- W2138678864 cites W2016263791 @default.
- W2138678864 cites W2020313062 @default.
- W2138678864 cites W2021345753 @default.
- W2138678864 cites W2022495743 @default.
- W2138678864 cites W2024815256 @default.
- W2138678864 cites W2025822675 @default.
- W2138678864 cites W2027680549 @default.
- W2138678864 cites W2032524530 @default.
- W2138678864 cites W2035618810 @default.
- W2138678864 cites W2036767516 @default.
- W2138678864 cites W2038140476 @default.
- W2138678864 cites W2039337032 @default.
- W2138678864 cites W2039527621 @default.
- W2138678864 cites W2045030683 @default.
- W2138678864 cites W2046931618 @default.
- W2138678864 cites W2048587489 @default.
- W2138678864 cites W2049905679 @default.
- W2138678864 cites W2049947293 @default.
- W2138678864 cites W2054020202 @default.
- W2138678864 cites W2055521003 @default.
- W2138678864 cites W2059895383 @default.
- W2138678864 cites W2059935604 @default.
- W2138678864 cites W2060493797 @default.
- W2138678864 cites W2063131576 @default.
- W2138678864 cites W2064119981 @default.
- W2138678864 cites W2065532444 @default.
- W2138678864 cites W2066134476 @default.
- W2138678864 cites W2069746141 @default.
- W2138678864 cites W2069949026 @default.
- W2138678864 cites W2071464503 @default.
- W2138678864 cites W2072450611 @default.
- W2138678864 cites W2074160421 @default.
- W2138678864 cites W2075234024 @default.
- W2138678864 cites W2075860675 @default.
- W2138678864 cites W2076241332 @default.
- W2138678864 cites W2077072698 @default.
- W2138678864 cites W2078162773 @default.
- W2138678864 cites W2083260532 @default.
- W2138678864 cites W2085129416 @default.
- W2138678864 cites W2086503221 @default.
- W2138678864 cites W2086911772 @default.
- W2138678864 cites W2088834250 @default.
- W2138678864 cites W2094884053 @default.
- W2138678864 cites W2100060444 @default.
- W2138678864 cites W2100738935 @default.
- W2138678864 cites W2100945845 @default.
- W2138678864 cites W2101328621 @default.
- W2138678864 cites W2101363646 @default.
- W2138678864 cites W2102568434 @default.
- W2138678864 cites W2104380511 @default.
- W2138678864 cites W2105731956 @default.
- W2138678864 cites W2108733091 @default.
- W2138678864 cites W2109691709 @default.
- W2138678864 cites W2111804305 @default.
- W2138678864 cites W2113769407 @default.