Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138692318> ?p ?o ?g. }
- W2138692318 endingPage "7062" @default.
- W2138692318 startingPage "7053" @default.
- W2138692318 abstract "The recent mapping of recombination hot spots in the human genome has demonstrated that crossover is a nonrandom process that occurs at well-defined positions along chromosomes. However, the mechanisms that direct hot-spot turnover in complex mammalian genomes are poorly understood. Analyses of the human genome are impaired by the inability to genetically dissect and molecularly manipulate recombinogenic regions to test their roles in regulating hot spots. Here, using the BXD recombinant inbred strains as a crossover library, three new recombination hot spots have been identified on mouse chromosome 19. Analyses of a highly polymorphic recombination hot spot (HS22) revealed that approximately 4% of recombinant molecules display complex and incomplete repair with discontinuous conversion tracts, as well as persistent heteroduplex DNA at crossover sites in mature spermatozoa. Also, sequence analysis of the wild house mouse revealed instability at the center of this hot spot. This suggests that complete repair is not required for completion of mammalian meiosis, a scenario that leaves duplex DNA containing mismatches at crossover sites." @default.
- W2138692318 created "2016-06-24" @default.
- W2138692318 creator A5013801580 @default.
- W2138692318 date "2007-10-15" @default.
- W2138692318 modified "2023-10-14" @default.
- W2138692318 title "A Highly Polymorphic Meiotic Recombination Mouse Hot Spot Exhibits Incomplete Repair" @default.
- W2138692318 cites W175491683 @default.
- W2138692318 cites W1791809201 @default.
- W2138692318 cites W1833842636 @default.
- W2138692318 cites W1971219155 @default.
- W2138692318 cites W1973611733 @default.
- W2138692318 cites W1976616117 @default.
- W2138692318 cites W1981372238 @default.
- W2138692318 cites W1983088153 @default.
- W2138692318 cites W1983497264 @default.
- W2138692318 cites W1987882116 @default.
- W2138692318 cites W1991971470 @default.
- W2138692318 cites W2004691787 @default.
- W2138692318 cites W2004718349 @default.
- W2138692318 cites W2009844552 @default.
- W2138692318 cites W2019659839 @default.
- W2138692318 cites W2024861163 @default.
- W2138692318 cites W2026269915 @default.
- W2138692318 cites W2026745781 @default.
- W2138692318 cites W2033226948 @default.
- W2138692318 cites W2033274989 @default.
- W2138692318 cites W2044228748 @default.
- W2138692318 cites W2050354772 @default.
- W2138692318 cites W2050375504 @default.
- W2138692318 cites W2062206026 @default.
- W2138692318 cites W2065332833 @default.
- W2138692318 cites W2067007270 @default.
- W2138692318 cites W2072688044 @default.
- W2138692318 cites W2074552729 @default.
- W2138692318 cites W2079915982 @default.
- W2138692318 cites W2087850275 @default.
- W2138692318 cites W2111398277 @default.
- W2138692318 cites W2120116685 @default.
- W2138692318 cites W2121920007 @default.
- W2138692318 cites W2127513751 @default.
- W2138692318 cites W2129555021 @default.
- W2138692318 cites W2132503128 @default.
- W2138692318 cites W2133272121 @default.
- W2138692318 cites W2160618807 @default.
- W2138692318 cites W2171041504 @default.
- W2138692318 cites W2217809488 @default.
- W2138692318 cites W2256016482 @default.
- W2138692318 cites W2400479986 @default.
- W2138692318 cites W4229715290 @default.
- W2138692318 cites W4234660780 @default.
- W2138692318 cites W4240283299 @default.
- W2138692318 doi "https://doi.org/10.1128/mcb.00874-07" @default.
- W2138692318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2168899" @default.
- W2138692318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17709383" @default.
- W2138692318 hasPublicationYear "2007" @default.
- W2138692318 type Work @default.
- W2138692318 sameAs 2138692318 @default.
- W2138692318 citedByCount "25" @default.
- W2138692318 countsByYear W21386923182012 @default.
- W2138692318 countsByYear W21386923182013 @default.
- W2138692318 countsByYear W21386923182014 @default.
- W2138692318 countsByYear W21386923182015 @default.
- W2138692318 countsByYear W21386923182016 @default.
- W2138692318 countsByYear W21386923182017 @default.
- W2138692318 countsByYear W21386923182018 @default.
- W2138692318 countsByYear W21386923182019 @default.
- W2138692318 crossrefType "journal-article" @default.
- W2138692318 hasAuthorship W2138692318A5013801580 @default.
- W2138692318 hasBestOaLocation W21386923181 @default.
- W2138692318 hasConcept C101434241 @default.
- W2138692318 hasConcept C102744134 @default.
- W2138692318 hasConcept C104317684 @default.
- W2138692318 hasConcept C111919701 @default.
- W2138692318 hasConcept C115220002 @default.
- W2138692318 hasConcept C127764415 @default.
- W2138692318 hasConcept C134494468 @default.
- W2138692318 hasConcept C141231307 @default.
- W2138692318 hasConcept C148196450 @default.
- W2138692318 hasConcept C156695909 @default.
- W2138692318 hasConcept C199672914 @default.
- W2138692318 hasConcept C30481170 @default.
- W2138692318 hasConcept C40767141 @default.
- W2138692318 hasConcept C41008148 @default.
- W2138692318 hasConcept C50919411 @default.
- W2138692318 hasConcept C54355233 @default.
- W2138692318 hasConcept C552990157 @default.
- W2138692318 hasConcept C82040048 @default.
- W2138692318 hasConcept C86803240 @default.
- W2138692318 hasConceptScore W2138692318C101434241 @default.
- W2138692318 hasConceptScore W2138692318C102744134 @default.
- W2138692318 hasConceptScore W2138692318C104317684 @default.
- W2138692318 hasConceptScore W2138692318C111919701 @default.
- W2138692318 hasConceptScore W2138692318C115220002 @default.
- W2138692318 hasConceptScore W2138692318C127764415 @default.
- W2138692318 hasConceptScore W2138692318C134494468 @default.
- W2138692318 hasConceptScore W2138692318C141231307 @default.
- W2138692318 hasConceptScore W2138692318C148196450 @default.
- W2138692318 hasConceptScore W2138692318C156695909 @default.