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- W2138695815 abstract "Multiple sclerosis (MS) is a chronic demyelinating disorder of unknown etiology, possibly caused by a virus or virus-triggered immunopathology. The virus might reactivate after years of latency and lyse oligodendrocytes, as in progressive multifocal leukoencephalopathy, or initiate immunopathological demyelination, as in animals infected with Theiler’s murine encephalomyelitis virus or coronaviruses. The argument for a viral cause of MS is supported by epidemiological analyses and studies of MS in identical twins, indicating that disease is acquired. However, the most important evidence is the presence of bands of oligoclonal IgG (OCBs) in MS brain and CSF that persist throughout the lifetime of the patient. OCBs are found almost exclusively in infectious CNS disorders, and antigenic targets of OCBs represent the agent that causes disease. Here, the authors review past attempts to identify an infectious agent in MS brain cells and discuss the promise of using recombinant antibodies generated from clonally expanded plasma cells in brain and CSF to identify disease-relevant antigens. They show how this strategy has been used successfully to analyze antigen specificity in subacute sclerosing panencephalitis, a chronic encephalitis caused by measles virus, and in neuromyelitis optica, a chronic autoimmune demyelinating disease produced by antibodies directed against the aquaporin-4 water channel." @default.
- W2138695815 created "2016-06-24" @default.
- W2138695815 creator A5010326392 @default.
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- W2138695815 creator A5039030016 @default.
- W2138695815 creator A5074639269 @default.
- W2138695815 creator A5088416439 @default.
- W2138695815 date "2011-11-29" @default.
- W2138695815 modified "2023-10-04" @default.
- W2138695815 title "Viruses and Multiple Sclerosis" @default.
- W2138695815 cites W1599964077 @default.
- W2138695815 cites W1650999727 @default.
- W2138695815 cites W1951893962 @default.
- W2138695815 cites W1953446118 @default.
- W2138695815 cites W1964114210 @default.
- W2138695815 cites W1964623828 @default.
- W2138695815 cites W1969420894 @default.
- W2138695815 cites W1972442533 @default.
- W2138695815 cites W1975434091 @default.
- W2138695815 cites W1980567374 @default.
- W2138695815 cites W1982686463 @default.
- W2138695815 cites W1983822014 @default.
- W2138695815 cites W1985225827 @default.
- W2138695815 cites W1986091093 @default.
- W2138695815 cites W1987057401 @default.
- W2138695815 cites W1992203744 @default.
- W2138695815 cites W1994966944 @default.
- W2138695815 cites W1995107799 @default.
- W2138695815 cites W1995373289 @default.
- W2138695815 cites W1995927391 @default.
- W2138695815 cites W1996888234 @default.
- W2138695815 cites W1998258994 @default.
- W2138695815 cites W2000940717 @default.
- W2138695815 cites W2001115275 @default.
- W2138695815 cites W2006528533 @default.
- W2138695815 cites W2006660240 @default.
- W2138695815 cites W2010649076 @default.
- W2138695815 cites W2014649886 @default.
- W2138695815 cites W2015065187 @default.
- W2138695815 cites W2019009797 @default.
- W2138695815 cites W2021310559 @default.
- W2138695815 cites W2026991127 @default.
- W2138695815 cites W2027452351 @default.
- W2138695815 cites W2028830390 @default.
- W2138695815 cites W2030868322 @default.
- W2138695815 cites W2030908842 @default.
- W2138695815 cites W2033063046 @default.
- W2138695815 cites W2037979244 @default.
- W2138695815 cites W2041024700 @default.
- W2138695815 cites W2047422536 @default.
- W2138695815 cites W2048232955 @default.
- W2138695815 cites W2048694754 @default.
- W2138695815 cites W2049616668 @default.
- W2138695815 cites W2051309117 @default.
- W2138695815 cites W2055553707 @default.
- W2138695815 cites W2056307870 @default.
- W2138695815 cites W2060684288 @default.
- W2138695815 cites W2061502684 @default.
- W2138695815 cites W2061760862 @default.
- W2138695815 cites W2064211556 @default.
- W2138695815 cites W2064370896 @default.
- W2138695815 cites W2064693789 @default.
- W2138695815 cites W2068196065 @default.
- W2138695815 cites W2069461569 @default.
- W2138695815 cites W2070614980 @default.
- W2138695815 cites W2072698880 @default.
- W2138695815 cites W2073251871 @default.
- W2138695815 cites W2074074558 @default.
- W2138695815 cites W2075740314 @default.
- W2138695815 cites W2077427574 @default.
- W2138695815 cites W2079012822 @default.
- W2138695815 cites W2080463438 @default.
- W2138695815 cites W2080476124 @default.
- W2138695815 cites W2081632246 @default.
- W2138695815 cites W2087550264 @default.
- W2138695815 cites W2088059866 @default.
- W2138695815 cites W2089094356 @default.
- W2138695815 cites W2090297349 @default.
- W2138695815 cites W2092404255 @default.
- W2138695815 cites W2100140177 @default.
- W2138695815 cites W2101190412 @default.
- W2138695815 cites W2108115821 @default.
- W2138695815 cites W2109592485 @default.
- W2138695815 cites W2114818215 @default.
- W2138695815 cites W2114832666 @default.
- W2138695815 cites W2116458521 @default.
- W2138695815 cites W2117650131 @default.
- W2138695815 cites W2120238028 @default.
- W2138695815 cites W2121508671 @default.
- W2138695815 cites W2122655209 @default.
- W2138695815 cites W2123787670 @default.
- W2138695815 cites W2135069984 @default.
- W2138695815 cites W2139127044 @default.
- W2138695815 cites W2139230166 @default.
- W2138695815 cites W2140630337 @default.
- W2138695815 cites W2141111992 @default.
- W2138695815 cites W2147062889 @default.
- W2138695815 cites W2147528615 @default.