FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138717871> ?p ?o ?g. }

• W2138717871 endingPage "6" @default.
• W2138717871 startingPage "943" @default.
• W2138717871 abstract "Radiation survival curves were generated for V79 Chinese hamster and two human lung cancer cell lines (NCI-H460 and NCI-H249) with doubling times of 10, 20, and 85 h, respectively, using a standard clonogenic assay, a dye exclusion assay, and a semiautomated colorimetric assay utilizing a tetrazolium salt, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylformazan bromide. Comparable results for D0 and extrapolation number (n) were observed for all assays in the lines with doubling times of 10 and 20 h. In these instances the tumor cell lines had undergone seven or more doublings after radiation. For the tumor line (H249) with an 80-h doubling time the D0S were comparable between the assays while the extrapolation number was increased in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylformazan bromide assay, a result probably related to the lower number of doublings (less than 4) after radiation. We then tested the ability of the assays to detect radiation protection and sensitization using known agents. We found that cysteamine treatment resulted in radioprotection (by a factor of 8 at 8 Gy) while 5-bromo-2-deoxyuridine incorporation caused enhancement of radiation sensitivity in all three assays. We conclude that, while optimal conditions for each cell line (cell number plated and doubling time) must be established, using characterized tumor cell lines, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylformazan bromide assay could be automated and thus be of great value in screening large numbers of potential radiosensitizers or protectors." @default.
• W2138717871 created "2016-06-24" @default.
• W2138717871 creator A5014699467 @default.
• W2138717871 creator A5048865240 @default.
• W2138717871 creator A5059166265 @default.
• W2138717871 creator A5072939048 @default.
• W2138717871 creator A5080571689 @default.
• W2138717871 date "1987-02-15" @default.
• W2138717871 modified "2023-10-03" @default.
• W2138717871 title "Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity." @default.
• W2138717871 cites W1480773154 @default.
• W2138717871 cites W1512563776 @default.
• W2138717871 cites W15505271 @default.
• W2138717871 cites W1564426280 @default.
• W2138717871 cites W1659509344 @default.
• W2138717871 cites W1937165983 @default.
• W2138717871 cites W1988566566 @default.
• W2138717871 cites W2002305721 @default.
• W2138717871 cites W2049474696 @default.
• W2138717871 cites W2067722023 @default.
• W2138717871 cites W2072224482 @default.
• W2138717871 cites W2082884871 @default.
• W2138717871 cites W2108834897 @default.
• W2138717871 cites W2114918609 @default.
• W2138717871 cites W2162160527 @default.
• W2138717871 cites W2413364007 @default.
• W2138717871 cites W283520413 @default.
• W2138717871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3802101" @default.
• W2138717871 hasPublicationYear "1987" @default.
• W2138717871 type Work @default.
• W2138717871 sameAs 2138717871 @default.
• W2138717871 citedByCount "208" @default.
• W2138717871 countsByYear W21387178712012 @default.
• W2138717871 countsByYear W21387178712013 @default.
• W2138717871 countsByYear W21387178712014 @default.
• W2138717871 countsByYear W21387178712015 @default.
• W2138717871 countsByYear W21387178712016 @default.
• W2138717871 countsByYear W21387178712017 @default.
• W2138717871 countsByYear W21387178712018 @default.
• W2138717871 countsByYear W21387178712019 @default.
• W2138717871 countsByYear W21387178712020 @default.
• W2138717871 countsByYear W21387178712021 @default.
• W2138717871 countsByYear W21387178712022 @default.
• W2138717871 countsByYear W21387178712023 @default.
• W2138717871 crossrefType "journal-article" @default.
• W2138717871 hasAuthorship W2138717871A5014699467 @default.
• W2138717871 hasAuthorship W2138717871A5048865240 @default.
• W2138717871 hasAuthorship W2138717871A5059166265 @default.
• W2138717871 hasAuthorship W2138717871A5072939048 @default.
• W2138717871 hasAuthorship W2138717871A5080571689 @default.
• W2138717871 hasConcept C117262875 @default.
• W2138717871 hasConcept C126322002 @default.
• W2138717871 hasConcept C153911025 @default.
• W2138717871 hasConcept C178790620 @default.
• W2138717871 hasConcept C185592680 @default.
• W2138717871 hasConcept C206684579 @default.
• W2138717871 hasConcept C2776300020 @default.
• W2138717871 hasConcept C2776428644 @default.
• W2138717871 hasConcept C2776892249 @default.
• W2138717871 hasConcept C48900799 @default.
• W2138717871 hasConcept C509974204 @default.
• W2138717871 hasConcept C54355233 @default.
• W2138717871 hasConcept C55493867 @default.
• W2138717871 hasConcept C71924100 @default.
• W2138717871 hasConcept C81885089 @default.
• W2138717871 hasConcept C86803240 @default.
• W2138717871 hasConceptScore W2138717871C117262875 @default.
• W2138717871 hasConceptScore W2138717871C126322002 @default.
• W2138717871 hasConceptScore W2138717871C153911025 @default.
• W2138717871 hasConceptScore W2138717871C178790620 @default.
• W2138717871 hasConceptScore W2138717871C185592680 @default.
• W2138717871 hasConceptScore W2138717871C206684579 @default.
• W2138717871 hasConceptScore W2138717871C2776300020 @default.
• W2138717871 hasConceptScore W2138717871C2776428644 @default.
• W2138717871 hasConceptScore W2138717871C2776892249 @default.
• W2138717871 hasConceptScore W2138717871C48900799 @default.
• W2138717871 hasConceptScore W2138717871C509974204 @default.
• W2138717871 hasConceptScore W2138717871C54355233 @default.
• W2138717871 hasConceptScore W2138717871C55493867 @default.
• W2138717871 hasConceptScore W2138717871C71924100 @default.
• W2138717871 hasConceptScore W2138717871C81885089 @default.
• W2138717871 hasConceptScore W2138717871C86803240 @default.
• W2138717871 hasIssue "4" @default.
• W2138717871 hasLocation W21387178711 @default.
• W2138717871 hasOpenAccess W2138717871 @default.
• W2138717871 hasPrimaryLocation W21387178711 @default.
• W2138717871 hasRelatedWork W1965115053 @default.
• W2138717871 hasRelatedWork W2067692847 @default.
• W2138717871 hasRelatedWork W2072308365 @default.
• W2138717871 hasRelatedWork W2080500177 @default.
• W2138717871 hasRelatedWork W2083905255 @default.
• W2138717871 hasRelatedWork W2129198290 @default.
• W2138717871 hasRelatedWork W2138717871 @default.
• W2138717871 hasRelatedWork W2170698671 @default.
• W2138717871 hasRelatedWork W2201990748 @default.
• W2138717871 hasRelatedWork W35469703 @default.
• W2138717871 hasVolume "47" @default.
• W2138717871 isParatext "false" @default.

• next