FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2138731844> ?p ?o ?g. }

• W2138731844 endingPage "298" @default.
• W2138731844 startingPage "289" @default.
• W2138731844 abstract "Parkinson’s disease (PD) is the second most common neurodegenerative disease, yet its etiology and pathogenesis are poorly understood. PD is characterized by selective dopaminergic (DAergic) degeneration and progressive hypokinetic motor impairment. Mutations in dj-1 cause autosomal recessive early-onset PD. DJ-1 is thought to protect DAergic neurons via an antioxidant mechanism, but the precise basis of this protection has not yet been resolved. Aging and manganese (Mn) exposure are significant non-genetic risk factors for PD. Caenorhabditis elegans (C. elegans) is an optimal model for PD and aging studies because of its simple nervous system, conserved DAergic machinery, and short 20-day lifespan. Here we tested the hypothesis that C. elegans DJ-1 homologues were protective against Mn-induced DAergic toxicity in an age-dependent manner. We showed that the deletion of C. elegans DJ-1 related (djr) genes, djr-1.2, decreased survival after Mn exposure. djr-1.2, the DJ-1 homologue was expressed in DAergic neurons and its deletion decreased lifespan and dopamine (DA)-dependent dauer movement behavior after Mn exposure. We also tested the role of DAF-16 as a regulator of dj-1.2 interaction with Mn toxicity. Lifespan defects resulting from djr-1.2 deletion could be restored to normal by overexpression of either DJR-1.2 or DAF-16. Furthermore, dauer movement alterations after djr-1.2 deletion were abolished by constitutive activation of DAF-16 through mutation of its inhibitor, DAF-2 insulin receptor. Taken together, our results reveal PD-relevant interactions between aging, the PD environmental risk factor manganese, and homologues of the established PD genetic risk factor DJ-1. Our data demonstrate a novel role for the DJ-1 homologue, djr-1.2, in mitigating Mn-dependent lifespan reduction and DA signaling alterations, involving DAF-2/DAF-16 signaling." @default.
• W2138731844 created "2016-06-24" @default.
• W2138731844 creator A5002802326 @default.
• W2138731844 creator A5025576109 @default.
• W2138731844 creator A5027976892 @default.
• W2138731844 creator A5035503566 @default.
• W2138731844 creator A5050958673 @default.
• W2138731844 creator A5072815126 @default.
• W2138731844 creator A5081869093 @default.
• W2138731844 date "2015-01-01" @default.
• W2138731844 modified "2023-10-18" @default.
• W2138731844 title "Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease" @default.
• W2138731844 cites W1237982461 @default.
• W2138731844 cites W1493589267 @default.
• W2138731844 cites W1540141415 @default.
• W2138731844 cites W1569358416 @default.
• W2138731844 cites W1967603366 @default.
• W2138731844 cites W1967678081 @default.
• W2138731844 cites W1972705554 @default.
• W2138731844 cites W1974183873 @default.
• W2138731844 cites W1974212152 @default.
• W2138731844 cites W1974843588 @default.
• W2138731844 cites W1980504496 @default.
• W2138731844 cites W1981550027 @default.
• W2138731844 cites W1982700743 @default.
• W2138731844 cites W1995761382 @default.
• W2138731844 cites W1996079680 @default.
• W2138731844 cites W1997394431 @default.
• W2138731844 cites W2012112859 @default.
• W2138731844 cites W2012553919 @default.
• W2138731844 cites W2020189764 @default.
• W2138731844 cites W2022508149 @default.
• W2138731844 cites W2024494094 @default.
• W2138731844 cites W2026841498 @default.
• W2138731844 cites W2027222718 @default.
• W2138731844 cites W2028099760 @default.
• W2138731844 cites W2028680240 @default.
• W2138731844 cites W2031022912 @default.
• W2138731844 cites W2031759600 @default.
• W2138731844 cites W2037079848 @default.
• W2138731844 cites W2042062646 @default.
• W2138731844 cites W2052414114 @default.
• W2138731844 cites W2059595592 @default.
• W2138731844 cites W2063382649 @default.
• W2138731844 cites W2065191163 @default.
• W2138731844 cites W2065938547 @default.
• W2138731844 cites W2066134019 @default.
• W2138731844 cites W2067354437 @default.
• W2138731844 cites W2068636447 @default.
• W2138731844 cites W2070782607 @default.
• W2138731844 cites W2076196975 @default.
• W2138731844 cites W2077035886 @default.
• W2138731844 cites W2081845158 @default.
• W2138731844 cites W2085062185 @default.
• W2138731844 cites W2085452364 @default.
• W2138731844 cites W2091852463 @default.
• W2138731844 cites W2094631352 @default.
• W2138731844 cites W2095908732 @default.
• W2138731844 cites W2103743923 @default.
• W2138731844 cites W2104382960 @default.
• W2138731844 cites W2127558621 @default.
• W2138731844 cites W2132556925 @default.
• W2138731844 cites W2133237042 @default.
• W2138731844 cites W2138336750 @default.
• W2138731844 cites W2141918542 @default.
• W2138731844 cites W2145048106 @default.
• W2138731844 cites W2149343596 @default.
• W2138731844 cites W2152014584 @default.
• W2138731844 cites W2158474392 @default.
• W2138731844 cites W2163792161 @default.
• W2138731844 cites W2165246198 @default.
• W2138731844 cites W2166031999 @default.
• W2138731844 cites W2167054321 @default.
• W2138731844 cites W2169466661 @default.
• W2138731844 cites W2170748127 @default.
• W2138731844 cites W2243758486 @default.
• W2138731844 cites W2290851825 @default.
• W2138731844 cites W4232723971 @default.
• W2138731844 cites W60943716 @default.
• W2138731844 doi "https://doi.org/10.1039/c4mt00292j" @default.
• W2138731844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4479152" @default.
• W2138731844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25531510" @default.
• W2138731844 hasPublicationYear "2015" @default.
• W2138731844 type Work @default.
• W2138731844 sameAs 2138731844 @default.
• W2138731844 citedByCount "47" @default.
• W2138731844 countsByYear W21387318442015 @default.
• W2138731844 countsByYear W21387318442016 @default.
• W2138731844 countsByYear W21387318442017 @default.
• W2138731844 countsByYear W21387318442018 @default.
• W2138731844 countsByYear W21387318442019 @default.
• W2138731844 countsByYear W21387318442020 @default.
• W2138731844 countsByYear W21387318442021 @default.
• W2138731844 countsByYear W21387318442022 @default.
• W2138731844 countsByYear W21387318442023 @default.
• W2138731844 crossrefType "journal-article" @default.
• W2138731844 hasAuthorship W2138731844A5002802326 @default.
• W2138731844 hasAuthorship W2138731844A5025576109 @default.

• next