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- W2138755927 abstract "Tumour progression is strongly associated with a series of specific genetic changes in protooncogenes and tumour suppressor genes. One of the potential factors involved in tumorogenesis of squamous cell carcinomas is protooncogene c-erbB-2 (also known as neu or HER2). The authors analysed the expression of c-erbB-2 oncoprotein in 154 cases of laryngeal squamous cell carcinomas and its relationship to the clinical outcome of the patients. The difference in c-erbB-2 oncoprotein expression between the control group and cancer patients was on the statistical borderline (p=0.0470). There was no significant correlation between c-erbB-2 expression and sex and age of the patients, T stage, lymph node status, site and histopathological grading of the tumour and clinical outcome of the patients. Univariate analysis revealed no correlation between c-erbB-2 expression and survival rates. We conclude that immunohistological examination of c-erbB-2 on paraffin section is not a valuable prognostic factor in laryngeal carcinoma." @default.
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- W2138755927 date "1999-01-01" @default.
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- W2138755927 title "C-erbB-2 Immunostaining in Laryngeal Cancer" @default.
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- W2138755927 doi "https://doi.org/10.1080/00016489950181440" @default.
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