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- W2138757639 abstract "RATIONALE: The Comprehensive Care Centre for Thrombosis, Hemostasis and Immunodeficiencies in Frankfurt/Germany treats about 325 patients with hereditary (HAE, n= 320), or acquired (AAE, n= 5) angioedema. METHODS: Because of side effects of androgen-derivatives (Danazol®) and the fact that Danazol is not longer licenced in Germany, most of the patients with HAE are treated with C1-inhibitor-concentrate (Berinert P®) on demand. Several patients with frequent and severe attacks need individual replacement therapy (IRT) with C1-INH concentrate. Few patients get prophylactic treatment with adrogen-derivatives (Danazol®) and additional treatment with C1-INH-concentrate in an acute severe attack. The children with HAE are exclusively treated with C1-INH-concentrate on demand. More than 50 % of our patients are able to perform the C1-INH-concentrate administration as out patients at home (home treatment). We have long experience of home treatment with on - demand and prophylactic treatment with factor VIII and factor IX concentrate in patients with haemophilia as an established therapy. The principles of home treatment are to instruct the patient in reconstitution and administration of C1-inhibitor-concentrate as well as venopuncture by the physician. Each C1-INH-concentrate-substitution and each swelling-attack must be documented in a patient diary. RESULTS: The advantages of home treatment are a short time interval between the beginning of an attack and it's treatment. Immediate treatment prevents severe attacks and less consumption of C1-INH-concentrate is being observed. Our patients with home treatment have less hospitalization time and less absence from school or work CONCLUSIONS: . Patients with home treatment have a better quality of life." @default.
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- W2138757639 date "2006-02-01" @default.
- W2138757639 modified "2023-09-25" @default.
- W2138757639 title "Home Treatment in Patients with Hereditary Angiodema (HAE)" @default.
- W2138757639 doi "https://doi.org/10.1016/j.jaci.2005.12.716" @default.
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