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• W2138763100 abstract "Perhaps the most important factor to limit the effectiveness of vaccines against virus infections is that of virus variation. Successful vaccines have been developed against viruses such as those causing smallpox, measles, yellow fever and poliomyelitis, and they are effective against most circulating virus strains. However, with some viruses vaccination has been much less successful either because numerous antigenically distinct strains co-circulate, as is the case for rhinoviruses, or because new strains are continually emerging, as in the case of influenza virus. Despite the importance of virus variability, little is known about the factors that influence it and that are responsible for the dramatically different patterns of variation displayed by different viruses. The primary source of variation is obviously mutation, and it has been suggested in several recent papers that the extreme variability of some viruses may be a consequence of an unusually high rate of mutation (Holland et al., 1982; Reanney, 1984; Domingo et al., 1985; Saitou & Nei, 1986). The purpose of this analytical review is to summarize recent information about the mutation rates of eukaryotic viruses, and to discuss the relationship between such rates and virus variability in the field." @default.
• W2138763100 created "2016-06-24" @default.
• W2138763100 creator A5045206303 @default.
• W2138763100 creator A5082252071 @default.
• W2138763100 date "1987-11-01" @default.
• W2138763100 modified "2023-10-16" @default.
• W2138763100 title "The Mutation Rate and Variability of Eukaryotic Viruses: An Analytical Review" @default.
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• W2138763100 doi "https://doi.org/10.1099/0022-1317-68-11-2729" @default.
• W2138763100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3316486" @default.
• W2138763100 hasPublicationYear "1987" @default.
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