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• W2138801153 endingPage "418" @default.
• W2138801153 startingPage "405" @default.
• W2138801153 abstract "The transcriptional regulator DntR, a member of the LysR family, is a central element in a prototype bacterial cell-based biosensor for the detection of hazardous contamination of soil and groundwater by dinitrotoluenes. To optimise the sensitivity of the biosensor for such compounds we have chosen a rational design of the inducer-binding cavity based on knowledge of the three-dimensional structure of DntR. We report two crystal structures of DntR with acetate (resolution 2.6 Å) and thiocyanate (resolution 2.3 Å), respectively, occupying the inducer-binding cavity. These structures allow for the construction of models of DntR in complex with salicylate (Kd≅4 μM) and 2,4-dinitrotoluene that provide a basis for the design of mutant DntR with enhanced specificity for dinitrotoluenes. In both crystal structures DntR crystallises as a homodimer with a “head-to-tail” arrangement of monomers in the asymmetric unit. Analysis of the crystal structure has allowed the building of a full-length model of DntR in its biologically active homotetrameric form consisting of two “head-to-head” dimers. The implications of this model for the mechanism of transcription regulation by LysR proteins are discussed." @default.
• W2138801153 created "2016-06-24" @default.
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• W2138801153 date "2004-07-01" @default.
• W2138801153 modified "2023-10-18" @default.
• W2138801153 title "Development of a Bacterial Biosensor for Nitrotoluenes: The Crystal Structure of the Transcriptional Regulator DntR" @default.
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• W2138801153 doi "https://doi.org/10.1016/j.jmb.2004.04.071" @default.
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